Angiopoietin-2 primes infection-induced preterm delivery.

Current knowledge on the participation of angiopoietin-2 (Ang-2) in the inflammatory process and on the importance of bacterial endotoxins (LPS) in the induction of preterm delivery (PTD) led us to investigate the role of Ang-2/LPS interplay in the pathogenesis of PTD. At a first stage, Ang-2 was me...

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Autores principales:	Electra N Polyzou, Nikolaos E Evangelinakis, Aikaterini Pistiki, Antigone Kotsaki, Charalampos S Siristatidis, Charalambos G Chrelias, Emmanuel Salamalekis, Demetrios P Kassanos, Evangelos J Giamarellos-Bourboulis
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cb09dc2631ec467cbb3415305d4b93cb
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spelling	oai:doaj.org-article:cb09dc2631ec467cbb3415305d4b93cb2021-11-18T08:36:45ZAngiopoietin-2 primes infection-induced preterm delivery.1932-620310.1371/journal.pone.0086523https://doaj.org/article/cb09dc2631ec467cbb3415305d4b93cb2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24466134/?tool=EBIhttps://doaj.org/toc/1932-6203Current knowledge on the participation of angiopoietin-2 (Ang-2) in the inflammatory process and on the importance of bacterial endotoxins (LPS) in the induction of preterm delivery (PTD) led us to investigate the role of Ang-2/LPS interplay in the pathogenesis of PTD. At a first stage, Ang-2 was measured at the end of the first trimester of pregnancy in the serum of 50 women who delivered prematurely; of 88 women well-matched for age and parity who delivered full-term; and of 20 non-pregnant healthy women. Ang-2 was greater in pregnant than in non-pregnant women. The time until delivery was shorter among those with Ang-2 greater than 4 ng/ml (odds ratio for delivery until week 34; p: 0.040). To further investigate the role of Ang-2 for PTD, an experimental model of PTD induced by the intraperitoneal injection of LPS in mice was used. Ang-2 was administered intraperitoneally before LPS on day 14 of pregnancy. When Ang-2 was administered before the LPS diluent, all mice delivered full-term. However, administration of Ang-2 prior LPS accelerated further the time until delivery. Sacrifice experiments showed that the effect of Ang-2 was accompanied by decrease of the penetration of Evans Blue in the embryos and by increase of its penetration in maternal tissues. In parallel, the concentration of tumour necrosis factor-alpha in the maternal circulation, in fetal tissues and in the placentas was significantly decreased. Results indicate that Ang-2 accelerated the phenomena of PTD induced by LPS. This is related with deprivation of fetal perfusion.Electra N PolyzouNikolaos E EvangelinakisAikaterini PistikiAntigone KotsakiCharalampos S SiristatidisCharalambos G ChreliasEmmanuel SalamalekisDemetrios P KassanosEvangelos J Giamarellos-BourboulisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e86523 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Electra N Polyzou Nikolaos E Evangelinakis Aikaterini Pistiki Antigone Kotsaki Charalampos S Siristatidis Charalambos G Chrelias Emmanuel Salamalekis Demetrios P Kassanos Evangelos J Giamarellos-Bourboulis Angiopoietin-2 primes infection-induced preterm delivery.
description	Current knowledge on the participation of angiopoietin-2 (Ang-2) in the inflammatory process and on the importance of bacterial endotoxins (LPS) in the induction of preterm delivery (PTD) led us to investigate the role of Ang-2/LPS interplay in the pathogenesis of PTD. At a first stage, Ang-2 was measured at the end of the first trimester of pregnancy in the serum of 50 women who delivered prematurely; of 88 women well-matched for age and parity who delivered full-term; and of 20 non-pregnant healthy women. Ang-2 was greater in pregnant than in non-pregnant women. The time until delivery was shorter among those with Ang-2 greater than 4 ng/ml (odds ratio for delivery until week 34; p: 0.040). To further investigate the role of Ang-2 for PTD, an experimental model of PTD induced by the intraperitoneal injection of LPS in mice was used. Ang-2 was administered intraperitoneally before LPS on day 14 of pregnancy. When Ang-2 was administered before the LPS diluent, all mice delivered full-term. However, administration of Ang-2 prior LPS accelerated further the time until delivery. Sacrifice experiments showed that the effect of Ang-2 was accompanied by decrease of the penetration of Evans Blue in the embryos and by increase of its penetration in maternal tissues. In parallel, the concentration of tumour necrosis factor-alpha in the maternal circulation, in fetal tissues and in the placentas was significantly decreased. Results indicate that Ang-2 accelerated the phenomena of PTD induced by LPS. This is related with deprivation of fetal perfusion.
format	article
author	Electra N Polyzou Nikolaos E Evangelinakis Aikaterini Pistiki Antigone Kotsaki Charalampos S Siristatidis Charalambos G Chrelias Emmanuel Salamalekis Demetrios P Kassanos Evangelos J Giamarellos-Bourboulis
author_facet	Electra N Polyzou Nikolaos E Evangelinakis Aikaterini Pistiki Antigone Kotsaki Charalampos S Siristatidis Charalambos G Chrelias Emmanuel Salamalekis Demetrios P Kassanos Evangelos J Giamarellos-Bourboulis
author_sort	Electra N Polyzou
title	Angiopoietin-2 primes infection-induced preterm delivery.
title_short	Angiopoietin-2 primes infection-induced preterm delivery.
title_full	Angiopoietin-2 primes infection-induced preterm delivery.
title_fullStr	Angiopoietin-2 primes infection-induced preterm delivery.
title_full_unstemmed	Angiopoietin-2 primes infection-induced preterm delivery.
title_sort	angiopoietin-2 primes infection-induced preterm delivery.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/cb09dc2631ec467cbb3415305d4b93cb
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Angiopoietin-2 primes infection-induced preterm delivery.

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