Progression of Prothrombin Induced by Vitamin K Absence-II in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer-related death worldwide. Due to the lack of efficient tools for early detection, asymptomatic HCC patients are diagnosed at an advanced stage, leading to a poor prognosis. To improve survival, serum...

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Autores principales:	Yang Yang, Guangbing Li, Ziwen Lu, Yong Liu, Junjie Kong, Jun Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	hepatocellular carcinoma prothrombin induced by vitamin K absence-II biomarker diagnosis prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/cb0a51f14cec4e97b817f5077135a999
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spelling	oai:doaj.org-article:cb0a51f14cec4e97b817f5077135a9992021-11-10T06:36:26ZProgression of Prothrombin Induced by Vitamin K Absence-II in Hepatocellular Carcinoma2234-943X10.3389/fonc.2021.726213https://doaj.org/article/cb0a51f14cec4e97b817f5077135a9992021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.726213/fullhttps://doaj.org/toc/2234-943XHepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer-related death worldwide. Due to the lack of efficient tools for early detection, asymptomatic HCC patients are diagnosed at an advanced stage, leading to a poor prognosis. To improve survival, serum biomarker prothrombin induced by vitamin K absence-II (PIVKA-II) was under investigation. PIVKA-II is an abnormal protein produced in HCC. The coagulation function was insufficient due to the lack of Gla residues. Elevated PIVKA-II was associated with bad tumor behavior in terms of proliferation, metastasis, and invasion. Three major signaling pathways were proposed to clarify the mechanism. With the advantages including affordability, minimal invasiveness, convenience, and efficiency, PIVKA-II could improve HCC management consisting of four aspects. First, PIVKA-II was an effective and dynamic tool for improving HCC surveillance in high-risk population. Changes in the serum levels of PIVKA-II provided valuable molecular alteration information before imaging discovery. Second, PIVKA-II offered a complementary approach for HCC early detection. Compared to traditional diagnostic approaches, the combination of PIVKA-II and other biomarkers had better performance. Third, PIVKA-II was an indicator for the assessment of response to treatment in HCC. Preoperative assessment was for selecting personalized therapy, and postoperative measurement was for assessing treatment efficacy. Fourth, PIVKA-II was considered as a prognostic predictor for HCC. Patients with elevated PIVKA-II were more likely to develop microvascular invasion, metastasis, and recurrence.Yang YangYang YangGuangbing LiZiwen LuZiwen LuYong LiuJunjie KongJun LiuJun LiuFrontiers Media S.A.articlehepatocellular carcinomaprothrombin induced by vitamin K absence-IIbiomarkerdiagnosisprognosisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocellular carcinoma prothrombin induced by vitamin K absence-II biomarker diagnosis prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	hepatocellular carcinoma prothrombin induced by vitamin K absence-II biomarker diagnosis prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yang Yang Yang Yang Guangbing Li Ziwen Lu Ziwen Lu Yong Liu Junjie Kong Jun Liu Jun Liu Progression of Prothrombin Induced by Vitamin K Absence-II in Hepatocellular Carcinoma
description	Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer-related death worldwide. Due to the lack of efficient tools for early detection, asymptomatic HCC patients are diagnosed at an advanced stage, leading to a poor prognosis. To improve survival, serum biomarker prothrombin induced by vitamin K absence-II (PIVKA-II) was under investigation. PIVKA-II is an abnormal protein produced in HCC. The coagulation function was insufficient due to the lack of Gla residues. Elevated PIVKA-II was associated with bad tumor behavior in terms of proliferation, metastasis, and invasion. Three major signaling pathways were proposed to clarify the mechanism. With the advantages including affordability, minimal invasiveness, convenience, and efficiency, PIVKA-II could improve HCC management consisting of four aspects. First, PIVKA-II was an effective and dynamic tool for improving HCC surveillance in high-risk population. Changes in the serum levels of PIVKA-II provided valuable molecular alteration information before imaging discovery. Second, PIVKA-II offered a complementary approach for HCC early detection. Compared to traditional diagnostic approaches, the combination of PIVKA-II and other biomarkers had better performance. Third, PIVKA-II was an indicator for the assessment of response to treatment in HCC. Preoperative assessment was for selecting personalized therapy, and postoperative measurement was for assessing treatment efficacy. Fourth, PIVKA-II was considered as a prognostic predictor for HCC. Patients with elevated PIVKA-II were more likely to develop microvascular invasion, metastasis, and recurrence.
format	article
author	Yang Yang Yang Yang Guangbing Li Ziwen Lu Ziwen Lu Yong Liu Junjie Kong Jun Liu Jun Liu
author_facet	Yang Yang Yang Yang Guangbing Li Ziwen Lu Ziwen Lu Yong Liu Junjie Kong Jun Liu Jun Liu
author_sort	Yang Yang
title	Progression of Prothrombin Induced by Vitamin K Absence-II in Hepatocellular Carcinoma
title_short	Progression of Prothrombin Induced by Vitamin K Absence-II in Hepatocellular Carcinoma
title_full	Progression of Prothrombin Induced by Vitamin K Absence-II in Hepatocellular Carcinoma
title_fullStr	Progression of Prothrombin Induced by Vitamin K Absence-II in Hepatocellular Carcinoma
title_full_unstemmed	Progression of Prothrombin Induced by Vitamin K Absence-II in Hepatocellular Carcinoma
title_sort	progression of prothrombin induced by vitamin k absence-ii in hepatocellular carcinoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/cb0a51f14cec4e97b817f5077135a999
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Progression of Prothrombin Induced by Vitamin K Absence-II in Hepatocellular Carcinoma

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