SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis

SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis

FXR agonists have been investigated for the treatment of non-alcoholic steatohepatitis and liver fibrosis but the clinical efficacy is not optimal. Here the authors show that enhanced FXR SUMOylation in activated hepatic stellate cells reduces FXR signaling and that this can be rescued by SUMOylatio...

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Autores principales: Jiyu Zhou, Shuang Cui, Qingxian He, Yitong Guo, Xiaojie Pan, Pengfei Zhang, Ningning Huang, Chaoliang Ge, Guangji Wang, Frank J. Gonzalez, Hong Wang, Haiping Hao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/cb0ac40b9ecd4e1ebc0d9be07e906d1a
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spelling oai:doaj.org-article:cb0ac40b9ecd4e1ebc0d9be07e906d1a2021-12-02T14:40:40ZSUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis10.1038/s41467-019-14138-62041-1723https://doaj.org/article/cb0ac40b9ecd4e1ebc0d9be07e906d1a2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14138-6https://doaj.org/toc/2041-1723FXR agonists have been investigated for the treatment of non-alcoholic steatohepatitis and liver fibrosis but the clinical efficacy is not optimal. Here the authors show that enhanced FXR SUMOylation in activated hepatic stellate cells reduces FXR signaling and that this can be rescued by SUMOylation inhibitors.Jiyu ZhouShuang CuiQingxian HeYitong GuoXiaojie PanPengfei ZhangNingning HuangChaoliang GeGuangji WangFrank J. GonzalezHong WangHaiping HaoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jiyu Zhou
Shuang Cui
Qingxian He
Yitong Guo
Xiaojie Pan
Pengfei Zhang
Ningning Huang
Chaoliang Ge
Guangji Wang
Frank J. Gonzalez
Hong Wang
Haiping Hao
SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis
description FXR agonists have been investigated for the treatment of non-alcoholic steatohepatitis and liver fibrosis but the clinical efficacy is not optimal. Here the authors show that enhanced FXR SUMOylation in activated hepatic stellate cells reduces FXR signaling and that this can be rescued by SUMOylation inhibitors.
format article
author Jiyu Zhou
Shuang Cui
Qingxian He
Yitong Guo
Xiaojie Pan
Pengfei Zhang
Ningning Huang
Chaoliang Ge
Guangji Wang
Frank J. Gonzalez
Hong Wang
Haiping Hao
author_facet Jiyu Zhou
Shuang Cui
Qingxian He
Yitong Guo
Xiaojie Pan
Pengfei Zhang
Ningning Huang
Chaoliang Ge
Guangji Wang
Frank J. Gonzalez
Hong Wang
Haiping Hao
author_sort Jiyu Zhou
title SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis
title_short SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis
title_full SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis
title_fullStr SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis
title_full_unstemmed SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis
title_sort sumoylation inhibitors synergize with fxr agonists in combating liver fibrosis
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/cb0ac40b9ecd4e1ebc0d9be07e906d1a
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AT shuangcui sumoylationinhibitorssynergizewithfxragonistsincombatingliverfibrosis
AT qingxianhe sumoylationinhibitorssynergizewithfxragonistsincombatingliverfibrosis
AT yitongguo sumoylationinhibitorssynergizewithfxragonistsincombatingliverfibrosis
AT xiaojiepan sumoylationinhibitorssynergizewithfxragonistsincombatingliverfibrosis
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AT guangjiwang sumoylationinhibitorssynergizewithfxragonistsincombatingliverfibrosis
AT frankjgonzalez sumoylationinhibitorssynergizewithfxragonistsincombatingliverfibrosis
AT hongwang sumoylationinhibitorssynergizewithfxragonistsincombatingliverfibrosis
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