Combine therapy as a modern approach to treatment of allergic rhinitis

Allergic rhinitis (AR) is one the most common allergic diseases affecting from 10 to 40% of the population in different countries, including Russia. AR is a risk factor of bronchial asthma, other upper airway disease and may decrease patient quality of life, their productivity, increase probability...

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Autor principal:	Alexander V. Emelyanov
Formato:	article
Lenguaje:	RU
Publicado:	"Consilium Medicum" Publishing house 2021
Materias:	allergic rhinitis fixed dose combinations mometasone furoate olopatadine Medicine R
Acceso en línea:	https://doaj.org/article/cb0b020ceb08404699b58a15d142782f
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spelling	oai:doaj.org-article:cb0b020ceb08404699b58a15d142782f2021-12-01T12:22:36ZCombine therapy as a modern approach to treatment of allergic rhinitis0040-36602309-534210.26442/00403660.2021.08.200995https://doaj.org/article/cb0b020ceb08404699b58a15d142782f2021-08-01T00:00:00Zhttps://ter-arkhiv.ru/0040-3660/article/viewFile/79598/60214https://doaj.org/toc/0040-3660https://doaj.org/toc/2309-5342Allergic rhinitis (AR) is one the most common allergic diseases affecting from 10 to 40% of the population in different countries, including Russia. AR is a risk factor of bronchial asthma, other upper airway disease and may decrease patient quality of life, their productivity, increase probability of occupational traumatism, depression and anxiety. AR also presents a substantial economic burden. The rationale to use fixed dose combination of intranasal steroids and topical H1 antihistamines includes suboptimal control of symptoms by monotherapy, its complementary pharmacologic activity and the results of clinical trials. This review focused on fixed dose combination of intranasal mometasone furoate and olopataine. Double blind placebo-controlled and open clinical trials have confirmed that this combination decreased severity of nasal and ocular symptoms of seasonal and perennial AR, improved patient quality of life and had a good tolerability. Its efficacy was higher than those of monotherapy. Fast onset of action and sustainable effect on symptoms (during 1 yr) may improve adherence patients to the treatment and control of symptoms of AR.Alexander V. Emelyanov"Consilium Medicum" Publishing housearticleallergic rhinitisfixed dose combinationsmometasone furoateolopatadineMedicineRRUТерапевтический архив, Vol 93, Iss 8, Pp 986-990 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	allergic rhinitis fixed dose combinations mometasone furoate olopatadine Medicine R
spellingShingle	allergic rhinitis fixed dose combinations mometasone furoate olopatadine Medicine R Alexander V. Emelyanov Combine therapy as a modern approach to treatment of allergic rhinitis
description	Allergic rhinitis (AR) is one the most common allergic diseases affecting from 10 to 40% of the population in different countries, including Russia. AR is a risk factor of bronchial asthma, other upper airway disease and may decrease patient quality of life, their productivity, increase probability of occupational traumatism, depression and anxiety. AR also presents a substantial economic burden. The rationale to use fixed dose combination of intranasal steroids and topical H1 antihistamines includes suboptimal control of symptoms by monotherapy, its complementary pharmacologic activity and the results of clinical trials. This review focused on fixed dose combination of intranasal mometasone furoate and olopataine. Double blind placebo-controlled and open clinical trials have confirmed that this combination decreased severity of nasal and ocular symptoms of seasonal and perennial AR, improved patient quality of life and had a good tolerability. Its efficacy was higher than those of monotherapy. Fast onset of action and sustainable effect on symptoms (during 1 yr) may improve adherence patients to the treatment and control of symptoms of AR.
format	article
author	Alexander V. Emelyanov
author_facet	Alexander V. Emelyanov
author_sort	Alexander V. Emelyanov
title	Combine therapy as a modern approach to treatment of allergic rhinitis
title_short	Combine therapy as a modern approach to treatment of allergic rhinitis
title_full	Combine therapy as a modern approach to treatment of allergic rhinitis
title_fullStr	Combine therapy as a modern approach to treatment of allergic rhinitis
title_full_unstemmed	Combine therapy as a modern approach to treatment of allergic rhinitis
title_sort	combine therapy as a modern approach to treatment of allergic rhinitis
publisher	"Consilium Medicum" Publishing house
publishDate	2021
url	https://doaj.org/article/cb0b020ceb08404699b58a15d142782f
work_keys_str_mv	AT alexandervemelyanov combinetherapyasamodernapproachtotreatmentofallergicrhinitis
_version_	1718405200803266560

Combine therapy as a modern approach to treatment of allergic rhinitis

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