Baseline T-lymphocyte subset absolute counts can predict both outcome and severity in SARS-CoV-2 infected patients: a single center study

Abstract The aim of this study was to evaluate the role of baseline lymphocyte subset counts in predicting the outcome and severity of COVID-19 patients. Hospitalized patients confirmed to be infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were included and classified acco...

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Autores principales:	Marco Iannetta, Francesco Buccisano, Daniela Fraboni, Vincenzo Malagnino, Laura Campogiani, Elisabetta Teti, Ilaria Spalliera, Benedetta Rossi, Andrea Di Lorenzo, Raffaele Palmieri, Angela Crea, Marta Zordan, Pietro Vitale, Maria Teresa Voso, Massimo Andreoni, Loredana Sarmati
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cb0ba0c56b0c44439a9661299e7ba552
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spelling	oai:doaj.org-article:cb0ba0c56b0c44439a9661299e7ba5522021-12-02T17:41:33ZBaseline T-lymphocyte subset absolute counts can predict both outcome and severity in SARS-CoV-2 infected patients: a single center study10.1038/s41598-021-90983-02045-2322https://doaj.org/article/cb0ba0c56b0c44439a9661299e7ba5522021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90983-0https://doaj.org/toc/2045-2322Abstract The aim of this study was to evaluate the role of baseline lymphocyte subset counts in predicting the outcome and severity of COVID-19 patients. Hospitalized patients confirmed to be infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were included and classified according to in-hospital mortality (survivors/nonsurvivors) and the maximal oxygen support/ventilation supply required (nonsevere/severe). Demographics, clinical and laboratory data, and peripheral blood lymphocyte subsets were retrospectively analyzed. Overall, 160 patients were retrospectively included in the study. T-lymphocyte subset (total CD3+, CD3+ CD4+, CD3+ CD8+, CD3+ CD4+ CD8+ double positive [DP] and CD3+ CD4− CD8− double negative [DN]) absolute counts were decreased in nonsurvivors and in patients with severe disease compared to survivors and nonsevere patients (p < 0.001). Multivariable logistic regression analysis showed that absolute counts of CD3+ T-lymphocytes < 524 cells/µl, CD3+ CD4+ < 369 cells/µl, and the number of T-lymphocyte subsets below the cutoff (T-lymphocyte subset index [TLSI]) were independent predictors of in-hospital mortality. Baseline T-lymphocyte subset counts and TLSI were also predictive of disease severity (CD3+ < 733 cells/µl; CD3+ CD4+ < 426 cells/µl; CD3+ CD8+ < 262 cells/µl; CD3+ DP < 4.5 cells/µl; CD3+ DN < 18.5 cells/µl). The evaluation of peripheral T-lymphocyte absolute counts in the early stages of COVID-19 might represent a useful tool for identifying patients at increased risk of unfavorable outcomes.Marco IannettaFrancesco BuccisanoDaniela FraboniVincenzo MalagninoLaura CampogianiElisabetta TetiIlaria SpallieraBenedetta RossiAndrea Di LorenzoRaffaele PalmieriAngela CreaMarta ZordanPietro VitaleMaria Teresa VosoMassimo AndreoniLoredana SarmatiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marco Iannetta Francesco Buccisano Daniela Fraboni Vincenzo Malagnino Laura Campogiani Elisabetta Teti Ilaria Spalliera Benedetta Rossi Andrea Di Lorenzo Raffaele Palmieri Angela Crea Marta Zordan Pietro Vitale Maria Teresa Voso Massimo Andreoni Loredana Sarmati Baseline T-lymphocyte subset absolute counts can predict both outcome and severity in SARS-CoV-2 infected patients: a single center study
description	Abstract The aim of this study was to evaluate the role of baseline lymphocyte subset counts in predicting the outcome and severity of COVID-19 patients. Hospitalized patients confirmed to be infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were included and classified according to in-hospital mortality (survivors/nonsurvivors) and the maximal oxygen support/ventilation supply required (nonsevere/severe). Demographics, clinical and laboratory data, and peripheral blood lymphocyte subsets were retrospectively analyzed. Overall, 160 patients were retrospectively included in the study. T-lymphocyte subset (total CD3+, CD3+ CD4+, CD3+ CD8+, CD3+ CD4+ CD8+ double positive [DP] and CD3+ CD4− CD8− double negative [DN]) absolute counts were decreased in nonsurvivors and in patients with severe disease compared to survivors and nonsevere patients (p < 0.001). Multivariable logistic regression analysis showed that absolute counts of CD3+ T-lymphocytes < 524 cells/µl, CD3+ CD4+ < 369 cells/µl, and the number of T-lymphocyte subsets below the cutoff (T-lymphocyte subset index [TLSI]) were independent predictors of in-hospital mortality. Baseline T-lymphocyte subset counts and TLSI were also predictive of disease severity (CD3+ < 733 cells/µl; CD3+ CD4+ < 426 cells/µl; CD3+ CD8+ < 262 cells/µl; CD3+ DP < 4.5 cells/µl; CD3+ DN < 18.5 cells/µl). The evaluation of peripheral T-lymphocyte absolute counts in the early stages of COVID-19 might represent a useful tool for identifying patients at increased risk of unfavorable outcomes.
format	article
author	Marco Iannetta Francesco Buccisano Daniela Fraboni Vincenzo Malagnino Laura Campogiani Elisabetta Teti Ilaria Spalliera Benedetta Rossi Andrea Di Lorenzo Raffaele Palmieri Angela Crea Marta Zordan Pietro Vitale Maria Teresa Voso Massimo Andreoni Loredana Sarmati
author_facet	Marco Iannetta Francesco Buccisano Daniela Fraboni Vincenzo Malagnino Laura Campogiani Elisabetta Teti Ilaria Spalliera Benedetta Rossi Andrea Di Lorenzo Raffaele Palmieri Angela Crea Marta Zordan Pietro Vitale Maria Teresa Voso Massimo Andreoni Loredana Sarmati
author_sort	Marco Iannetta
title	Baseline T-lymphocyte subset absolute counts can predict both outcome and severity in SARS-CoV-2 infected patients: a single center study
title_short	Baseline T-lymphocyte subset absolute counts can predict both outcome and severity in SARS-CoV-2 infected patients: a single center study
title_full	Baseline T-lymphocyte subset absolute counts can predict both outcome and severity in SARS-CoV-2 infected patients: a single center study
title_fullStr	Baseline T-lymphocyte subset absolute counts can predict both outcome and severity in SARS-CoV-2 infected patients: a single center study
title_full_unstemmed	Baseline T-lymphocyte subset absolute counts can predict both outcome and severity in SARS-CoV-2 infected patients: a single center study
title_sort	baseline t-lymphocyte subset absolute counts can predict both outcome and severity in sars-cov-2 infected patients: a single center study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cb0ba0c56b0c44439a9661299e7ba552
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Baseline T-lymphocyte subset absolute counts can predict both outcome and severity in SARS-CoV-2 infected patients: a single center study

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