Nomogram of age-specific anti-Müllerian hormone levels in healthy Egyptian females.

<h4>Background</h4>Anti-Müllerian hormone (AMH) is an important determinant of ovarian reserve in fertility workups in many clinical settings. Thus, we investigated the age dependent decline in AMH specific to the Egyptian population and sought to establish an age dependent reference int...

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Autores principales:	Eman Ahmed El-Attar, Tamer A Hosny, Kiyoshi Ichihara, Rania N Bedair, Ahmed Salah El-Din Tork
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cb0c576711464612a9720c55d34d2cfa
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spelling	oai:doaj.org-article:cb0c576711464612a9720c55d34d2cfa2021-12-02T20:04:50ZNomogram of age-specific anti-Müllerian hormone levels in healthy Egyptian females.1932-620310.1371/journal.pone.0254858https://doaj.org/article/cb0c576711464612a9720c55d34d2cfa2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254858https://doaj.org/toc/1932-6203<h4>Background</h4>Anti-Müllerian hormone (AMH) is an important determinant of ovarian reserve in fertility workups in many clinical settings. Thus, we investigated the age dependent decline in AMH specific to the Egyptian population and sought to establish an age dependent reference interval parametrically.<h4>Methods</h4>Serum samples were collected from 841 apparently healthy women. AMH was measured using an electro-chemiluminescent technique. Box-Cox power transformation was used to make the AMH distribution Gaussian for parametric derivation of reference intervals.<h4>Results</h4>Power of 0.4 was found optimal for Gaussian transformation of AMH reference values. We demonstrate the strong negative relation between circulating AMH and female age with Spearman's correlation coefficient of rS = -0.528. Age-specific reference interval was determined for every 5 years of age from 16 to 49, and nomogram was constructed by smoothing the lines connecting adjacent lower and upper reference limits.<h4>Conclusion</h4>The age-specific reference intervals and the age-AMH nomogram could be valuable in the clinical practice of in reproductive medicine. To our knowledge, this is the first study to confirm AMH levels in Egyptian females. We were able to explore age-related AMH levels specific to Egyptian females in the fertile age group and to treat skewed AMH data in a multi-step scheme using power transformation. Thus, a more accurate nomogram was constructed accommodating a profile delineated for a wide age range and a rescaled AMH axis improving its usability.Eman Ahmed El-AttarTamer A HosnyKiyoshi IchiharaRania N BedairAhmed Salah El-Din TorkPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254858 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eman Ahmed El-Attar Tamer A Hosny Kiyoshi Ichihara Rania N Bedair Ahmed Salah El-Din Tork Nomogram of age-specific anti-Müllerian hormone levels in healthy Egyptian females.
description	<h4>Background</h4>Anti-Müllerian hormone (AMH) is an important determinant of ovarian reserve in fertility workups in many clinical settings. Thus, we investigated the age dependent decline in AMH specific to the Egyptian population and sought to establish an age dependent reference interval parametrically.<h4>Methods</h4>Serum samples were collected from 841 apparently healthy women. AMH was measured using an electro-chemiluminescent technique. Box-Cox power transformation was used to make the AMH distribution Gaussian for parametric derivation of reference intervals.<h4>Results</h4>Power of 0.4 was found optimal for Gaussian transformation of AMH reference values. We demonstrate the strong negative relation between circulating AMH and female age with Spearman's correlation coefficient of rS = -0.528. Age-specific reference interval was determined for every 5 years of age from 16 to 49, and nomogram was constructed by smoothing the lines connecting adjacent lower and upper reference limits.<h4>Conclusion</h4>The age-specific reference intervals and the age-AMH nomogram could be valuable in the clinical practice of in reproductive medicine. To our knowledge, this is the first study to confirm AMH levels in Egyptian females. We were able to explore age-related AMH levels specific to Egyptian females in the fertile age group and to treat skewed AMH data in a multi-step scheme using power transformation. Thus, a more accurate nomogram was constructed accommodating a profile delineated for a wide age range and a rescaled AMH axis improving its usability.
format	article
author	Eman Ahmed El-Attar Tamer A Hosny Kiyoshi Ichihara Rania N Bedair Ahmed Salah El-Din Tork
author_facet	Eman Ahmed El-Attar Tamer A Hosny Kiyoshi Ichihara Rania N Bedair Ahmed Salah El-Din Tork
author_sort	Eman Ahmed El-Attar
title	Nomogram of age-specific anti-Müllerian hormone levels in healthy Egyptian females.
title_short	Nomogram of age-specific anti-Müllerian hormone levels in healthy Egyptian females.
title_full	Nomogram of age-specific anti-Müllerian hormone levels in healthy Egyptian females.
title_fullStr	Nomogram of age-specific anti-Müllerian hormone levels in healthy Egyptian females.
title_full_unstemmed	Nomogram of age-specific anti-Müllerian hormone levels in healthy Egyptian females.
title_sort	nomogram of age-specific anti-müllerian hormone levels in healthy egyptian females.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/cb0c576711464612a9720c55d34d2cfa
work_keys_str_mv	AT emanahmedelattar nomogramofagespecificantimullerianhormonelevelsinhealthyegyptianfemales AT tamerahosny nomogramofagespecificantimullerianhormonelevelsinhealthyegyptianfemales AT kiyoshiichihara nomogramofagespecificantimullerianhormonelevelsinhealthyegyptianfemales AT ranianbedair nomogramofagespecificantimullerianhormonelevelsinhealthyegyptianfemales AT ahmedsalaheldintork nomogramofagespecificantimullerianhormonelevelsinhealthyegyptianfemales
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Nomogram of age-specific anti-Müllerian hormone levels in healthy Egyptian females.

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