Cognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampus–prefrontal cortex dysconnectivity
Dayalan Sampath,1 Monica Sathyanesan,1,2 Samuel S Newton1,2 1Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, 2Sioux Falls VA Healthcare System, Sioux Falls, SD, USA Abstract: Cognitive dysfunction is prevalent in psychiatric disorders. Def...
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Dove Medical Press
2017
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oai:doaj.org-article:cb0fa1ae46a7485c8503e0fec76ec8b62021-12-02T01:20:38ZCognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampus–prefrontal cortex dysconnectivity1178-2021https://doaj.org/article/cb0fa1ae46a7485c8503e0fec76ec8b62017-06-01T00:00:00Zhttps://www.dovepress.com/cognitive-dysfunction-in-major-depression-and-alzheimer39s-disease-is--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Dayalan Sampath,1 Monica Sathyanesan,1,2 Samuel S Newton1,2 1Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, 2Sioux Falls VA Healthcare System, Sioux Falls, SD, USA Abstract: Cognitive dysfunction is prevalent in psychiatric disorders. Deficits are observed in multiple domains, including working memory, executive function, attention, and information processing. Disability caused by cognitive dysfunction is frequently as debilitating as the prominent emotional disturbances. Interactions between the hippocampus and the prefrontal cortex are increasingly appreciated as an important link between cognition and emotion. Recent developments in optogenetics, imaging, and connectomics can enable the investigation of this circuit in a manner that is relevant to disease pathophysiology. The goal of this review is to shed light on the contributions of this circuit to cognitive dysfunction in neuropsychiatric disorders, focusing on Alzheimer’s disease and depression. Keywords: hippocampus, prefrontal cortex, cognition, depression, Alzheimer’s diseaseSampath DSathyanesan MNewton SSDove Medical PressarticleHippocampusPrefrontal cortexCognition DepressionAlzheimers diseaseNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 1509-1519 (2017) |
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DOAJ |
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DOAJ |
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EN |
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Hippocampus Prefrontal cortex Cognition Depression Alzheimers disease Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Hippocampus Prefrontal cortex Cognition Depression Alzheimers disease Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Sampath D Sathyanesan M Newton SS Cognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampus–prefrontal cortex dysconnectivity |
| description |
Dayalan Sampath,1 Monica Sathyanesan,1,2 Samuel S Newton1,2 1Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, 2Sioux Falls VA Healthcare System, Sioux Falls, SD, USA Abstract: Cognitive dysfunction is prevalent in psychiatric disorders. Deficits are observed in multiple domains, including working memory, executive function, attention, and information processing. Disability caused by cognitive dysfunction is frequently as debilitating as the prominent emotional disturbances. Interactions between the hippocampus and the prefrontal cortex are increasingly appreciated as an important link between cognition and emotion. Recent developments in optogenetics, imaging, and connectomics can enable the investigation of this circuit in a manner that is relevant to disease pathophysiology. The goal of this review is to shed light on the contributions of this circuit to cognitive dysfunction in neuropsychiatric disorders, focusing on Alzheimer’s disease and depression. Keywords: hippocampus, prefrontal cortex, cognition, depression, Alzheimer’s disease |
| format |
article |
| author |
Sampath D Sathyanesan M Newton SS |
| author_facet |
Sampath D Sathyanesan M Newton SS |
| author_sort |
Sampath D |
| title |
Cognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampus–prefrontal cortex dysconnectivity |
| title_short |
Cognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampus–prefrontal cortex dysconnectivity |
| title_full |
Cognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampus–prefrontal cortex dysconnectivity |
| title_fullStr |
Cognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampus–prefrontal cortex dysconnectivity |
| title_full_unstemmed |
Cognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampus–prefrontal cortex dysconnectivity |
| title_sort |
cognitive dysfunction in major depression and alzheimer's disease is associated with hippocampus–prefrontal cortex dysconnectivity |
| publisher |
Dove Medical Press |
| publishDate |
2017 |
| url |
https://doaj.org/article/cb0fa1ae46a7485c8503e0fec76ec8b6 |
| work_keys_str_mv |
AT sampathd cognitivedysfunctioninmajordepressionandalzheimer39sdiseaseisassociatedwithhippocampusndashprefrontalcortexdysconnectivity AT sathyanesanm cognitivedysfunctioninmajordepressionandalzheimer39sdiseaseisassociatedwithhippocampusndashprefrontalcortexdysconnectivity AT newtonss cognitivedysfunctioninmajordepressionandalzheimer39sdiseaseisassociatedwithhippocampusndashprefrontalcortexdysconnectivity |
| _version_ |
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