Complete diastereodivergence in asymmetric 1,6-addition reactions enabled by minimal modification of a chiral catalyst
For reactions producing numerous chiral centres, accessing all potential stereoisomers is synthetically appealing but difficult. Here, the authors report a stereodivergent 1,6-addition of azlactones where minimal changes to the catalyst structure switches the product selectivity.
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/cb122de58d3145f9950a5515d20f47b6 |
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| Sumario: | For reactions producing numerous chiral centres, accessing all potential stereoisomers is synthetically appealing but difficult. Here, the authors report a stereodivergent 1,6-addition of azlactones where minimal changes to the catalyst structure switches the product selectivity. |
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