Complete diastereodivergence in asymmetric 1,6-addition reactions enabled by minimal modification of a chiral catalyst

For reactions producing numerous chiral centres, accessing all potential stereoisomers is synthetically appealing but difficult. Here, the authors report a stereodivergent 1,6-addition of azlactones where minimal changes to the catalyst structure switches the product selectivity.

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Autores principales:	Daisuke Uraguchi, Ken Yoshioka, Takashi Ooi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cb122de58d3145f9950a5515d20f47b6
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spelling	oai:doaj.org-article:cb122de58d3145f9950a5515d20f47b62021-12-02T15:38:55ZComplete diastereodivergence in asymmetric 1,6-addition reactions enabled by minimal modification of a chiral catalyst10.1038/ncomms147932041-1723https://doaj.org/article/cb122de58d3145f9950a5515d20f47b62017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14793https://doaj.org/toc/2041-1723For reactions producing numerous chiral centres, accessing all potential stereoisomers is synthetically appealing but difficult. Here, the authors report a stereodivergent 1,6-addition of azlactones where minimal changes to the catalyst structure switches the product selectivity.Daisuke UraguchiKen YoshiokaTakashi OoiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daisuke Uraguchi Ken Yoshioka Takashi Ooi Complete diastereodivergence in asymmetric 1,6-addition reactions enabled by minimal modification of a chiral catalyst
description	For reactions producing numerous chiral centres, accessing all potential stereoisomers is synthetically appealing but difficult. Here, the authors report a stereodivergent 1,6-addition of azlactones where minimal changes to the catalyst structure switches the product selectivity.
format	article
author	Daisuke Uraguchi Ken Yoshioka Takashi Ooi
author_facet	Daisuke Uraguchi Ken Yoshioka Takashi Ooi
author_sort	Daisuke Uraguchi
title	Complete diastereodivergence in asymmetric 1,6-addition reactions enabled by minimal modification of a chiral catalyst
title_short	Complete diastereodivergence in asymmetric 1,6-addition reactions enabled by minimal modification of a chiral catalyst
title_full	Complete diastereodivergence in asymmetric 1,6-addition reactions enabled by minimal modification of a chiral catalyst
title_fullStr	Complete diastereodivergence in asymmetric 1,6-addition reactions enabled by minimal modification of a chiral catalyst
title_full_unstemmed	Complete diastereodivergence in asymmetric 1,6-addition reactions enabled by minimal modification of a chiral catalyst
title_sort	complete diastereodivergence in asymmetric 1,6-addition reactions enabled by minimal modification of a chiral catalyst
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cb122de58d3145f9950a5515d20f47b6
work_keys_str_mv	AT daisukeuraguchi completediastereodivergenceinasymmetric16additionreactionsenabledbyminimalmodificationofachiralcatalyst AT kenyoshioka completediastereodivergenceinasymmetric16additionreactionsenabledbyminimalmodificationofachiralcatalyst AT takashiooi completediastereodivergenceinasymmetric16additionreactionsenabledbyminimalmodificationofachiralcatalyst
_version_	1718386074015760384

Complete diastereodivergence in asymmetric 1,6-addition reactions enabled by minimal modification of a chiral catalyst

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