Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1
Excitotoxicity due to excessive glutamate release causes oxidative stress and neuronal death, and is a feature of many brain diseases. Here the authors show that protein kinase D1 is inactivated by excitotoxicity in a model of stroke and that its activation can be neuroprotective.
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Nature Portfolio
2017
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oai:doaj.org-article:cb128c406cd844578138ccf113906e622021-12-02T14:41:09ZExcitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD110.1038/s41467-017-02322-52041-1723https://doaj.org/article/cb128c406cd844578138ccf113906e622017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02322-5https://doaj.org/toc/2041-1723Excitotoxicity due to excessive glutamate release causes oxidative stress and neuronal death, and is a feature of many brain diseases. Here the authors show that protein kinase D1 is inactivated by excitotoxicity in a model of stroke and that its activation can be neuroprotective.Julia Pose-UtrillaLucía García-GuerraAna Del PuertoAbraham MartínJerónimo Jurado-ArjonaNoelia S. De León-ReyesAndrea Gamir-MorrallaÁlvaro Sebastián-SerranoMónica García-GalloLeonor KremerJens FielitzChristofer IresonMª José Pérez-ÁlvarezIsidro FerrerFélix HernándezJesús ÁvilaMarina LasaMiguel R. CampaneroTeresa IglesiasNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017) |
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DOAJ |
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Science Q |
| spellingShingle |
Science Q Julia Pose-Utrilla Lucía García-Guerra Ana Del Puerto Abraham Martín Jerónimo Jurado-Arjona Noelia S. De León-Reyes Andrea Gamir-Morralla Álvaro Sebastián-Serrano Mónica García-Gallo Leonor Kremer Jens Fielitz Christofer Ireson Mª José Pérez-Álvarez Isidro Ferrer Félix Hernández Jesús Ávila Marina Lasa Miguel R. Campanero Teresa Iglesias Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1 |
| description |
Excitotoxicity due to excessive glutamate release causes oxidative stress and neuronal death, and is a feature of many brain diseases. Here the authors show that protein kinase D1 is inactivated by excitotoxicity in a model of stroke and that its activation can be neuroprotective. |
| format |
article |
| author |
Julia Pose-Utrilla Lucía García-Guerra Ana Del Puerto Abraham Martín Jerónimo Jurado-Arjona Noelia S. De León-Reyes Andrea Gamir-Morralla Álvaro Sebastián-Serrano Mónica García-Gallo Leonor Kremer Jens Fielitz Christofer Ireson Mª José Pérez-Álvarez Isidro Ferrer Félix Hernández Jesús Ávila Marina Lasa Miguel R. Campanero Teresa Iglesias |
| author_facet |
Julia Pose-Utrilla Lucía García-Guerra Ana Del Puerto Abraham Martín Jerónimo Jurado-Arjona Noelia S. De León-Reyes Andrea Gamir-Morralla Álvaro Sebastián-Serrano Mónica García-Gallo Leonor Kremer Jens Fielitz Christofer Ireson Mª José Pérez-Álvarez Isidro Ferrer Félix Hernández Jesús Ávila Marina Lasa Miguel R. Campanero Teresa Iglesias |
| author_sort |
Julia Pose-Utrilla |
| title |
Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1 |
| title_short |
Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1 |
| title_full |
Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1 |
| title_fullStr |
Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1 |
| title_full_unstemmed |
Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1 |
| title_sort |
excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by pkd1 |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/cb128c406cd844578138ccf113906e62 |
| work_keys_str_mv |
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| _version_ |
1718390020215144448 |