Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias

Catheter ablation is a common therapy for atrial fibrillation but disrupts cardiac cholinergic neurons. Here the authors report that cholinergic neurons innervate heart ventricles and show that their ablation leads to increased susceptibility to ventricular arrhythmias in mouse models and in patient...

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Autores principales:	Christiane Jungen, Katharina Scherschel, Christian Eickholt, Pawel Kuklik, Niklas Klatt, Nadja Bork, Tim Salzbrunn, Fares Alken, Stephan Angendohr, Christiane Klene, Janos Mester, Nikolaj Klöcker, Marieke W. Veldkamp, Udo Schumacher, Stephan Willems, Viacheslav O. Nikolaev, Christian Meyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cb15526be5334b77bb985b10ebd7ca12
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spelling	oai:doaj.org-article:cb15526be5334b77bb985b10ebd7ca122021-12-02T17:01:18ZDisruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias10.1038/ncomms141552041-1723https://doaj.org/article/cb15526be5334b77bb985b10ebd7ca122017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14155https://doaj.org/toc/2041-1723Catheter ablation is a common therapy for atrial fibrillation but disrupts cardiac cholinergic neurons. Here the authors report that cholinergic neurons innervate heart ventricles and show that their ablation leads to increased susceptibility to ventricular arrhythmias in mouse models and in patients.Christiane JungenKatharina ScherschelChristian EickholtPawel KuklikNiklas KlattNadja BorkTim SalzbrunnFares AlkenStephan AngendohrChristiane KleneJanos MesterNikolaj KlöckerMarieke W. VeldkampUdo SchumacherStephan WillemsViacheslav O. NikolaevChristian MeyerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christiane Jungen Katharina Scherschel Christian Eickholt Pawel Kuklik Niklas Klatt Nadja Bork Tim Salzbrunn Fares Alken Stephan Angendohr Christiane Klene Janos Mester Nikolaj Klöcker Marieke W. Veldkamp Udo Schumacher Stephan Willems Viacheslav O. Nikolaev Christian Meyer Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias
description	Catheter ablation is a common therapy for atrial fibrillation but disrupts cardiac cholinergic neurons. Here the authors report that cholinergic neurons innervate heart ventricles and show that their ablation leads to increased susceptibility to ventricular arrhythmias in mouse models and in patients.
format	article
author	Christiane Jungen Katharina Scherschel Christian Eickholt Pawel Kuklik Niklas Klatt Nadja Bork Tim Salzbrunn Fares Alken Stephan Angendohr Christiane Klene Janos Mester Nikolaj Klöcker Marieke W. Veldkamp Udo Schumacher Stephan Willems Viacheslav O. Nikolaev Christian Meyer
author_facet	Christiane Jungen Katharina Scherschel Christian Eickholt Pawel Kuklik Niklas Klatt Nadja Bork Tim Salzbrunn Fares Alken Stephan Angendohr Christiane Klene Janos Mester Nikolaj Klöcker Marieke W. Veldkamp Udo Schumacher Stephan Willems Viacheslav O. Nikolaev Christian Meyer
author_sort	Christiane Jungen
title	Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias
title_short	Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias
title_full	Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias
title_fullStr	Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias
title_full_unstemmed	Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias
title_sort	disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cb15526be5334b77bb985b10ebd7ca12
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Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias

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