Nanoscale hepatoprotective herbal decoction attenuates hepatic stellate cell activity and chloroform-induced liver damage in mice

Sherry Huang1, Shu-Jen Chang2, Miffy Yang3, Justin Jin-Ching Chen3, Walter H Chang41Department of Biomedical Engineering, Chung Yuan Christian University, Chungli, Taiwan; 2School of Pharmacy, China Medical University, Taichung, Taiwan; 3Center for Nano Bioengineering, 4Department of Biomedical Engi...

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Auteurs principaux:	Huang S, Chang SJ, Yang M, Chen JJ, Chang WH
Format:	article
Langue:	EN
Publié:	Dove Medical Press 2011
Sujets:	Medicine (General) R5-920
Accès en ligne:	https://doaj.org/article/cb166e47384b4d34a29fc2ea7b37a09f
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spelling	oai:doaj.org-article:cb166e47384b4d34a29fc2ea7b37a09f2021-12-02T02:34:26ZNanoscale hepatoprotective herbal decoction attenuates hepatic stellate cell activity and chloroform-induced liver damage in mice1176-91141178-2013https://doaj.org/article/cb166e47384b4d34a29fc2ea7b37a09f2011-07-01T00:00:00Zhttp://www.dovepress.com/nanoscale-hepatoprotective-herbal-decoction-attenuates-hepatic-stellat-a7787https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Sherry Huang1, Shu-Jen Chang2, Miffy Yang3, Justin Jin-Ching Chen3, Walter H Chang41Department of Biomedical Engineering, Chung Yuan Christian University, Chungli, Taiwan; 2School of Pharmacy, China Medical University, Taichung, Taiwan; 3Center for Nano Bioengineering, 4Department of Biomedical Engineering, Chung Yuan Christian University, Chungli, TaiwanBackground: San-Huang-Xie-Xin-Tang (SHXXT) decoction, a traditional Chinese medicine containing Rhei rhizome, Coptidis rhizome, and Scutellariae radix, is widely used in hepatoprotective therapy. However, preparation of the decoction requires addition of boiling water that causes loss of numerous effective components.Methods: To improve the bioavailability of the decoction, nanoscale SHXXT was developed. Chloroform-induced liver injury and hepatic stellate cell activity in mice were used to demonstrate the hepatoprotective characteristics of nanoscale SHXXT decoction.Results: Liver/body weight ratio and serum aspartate and alanine aminotranferase levels were recovered by the nanoscale SHXXT. TIMP-1 gene expression was inhibited and MMP-2 gene expression was accelerated in activated hepatic stellate cells.Conclusion: Nanoscale SHXXT decoction prepared in room temperature water could have preserved hepatoprotective ability. The results of this study indicate that nanoscale SHXXT could be extracted easily. The simple preparation of this herbal decoction is more convenient and energy-efficient.Keywords: Chinese herb medicine, San-Huang-Xie-Xin-Tang, nanoparticle, liver fibrosis&nbsp;Huang SChang SJYang MChen JJChang WHDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 1365-1371 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Huang S Chang SJ Yang M Chen JJ Chang WH Nanoscale hepatoprotective herbal decoction attenuates hepatic stellate cell activity and chloroform-induced liver damage in mice
description	Sherry Huang1, Shu-Jen Chang2, Miffy Yang3, Justin Jin-Ching Chen3, Walter H Chang41Department of Biomedical Engineering, Chung Yuan Christian University, Chungli, Taiwan; 2School of Pharmacy, China Medical University, Taichung, Taiwan; 3Center for Nano Bioengineering, 4Department of Biomedical Engineering, Chung Yuan Christian University, Chungli, TaiwanBackground: San-Huang-Xie-Xin-Tang (SHXXT) decoction, a traditional Chinese medicine containing Rhei rhizome, Coptidis rhizome, and Scutellariae radix, is widely used in hepatoprotective therapy. However, preparation of the decoction requires addition of boiling water that causes loss of numerous effective components.Methods: To improve the bioavailability of the decoction, nanoscale SHXXT was developed. Chloroform-induced liver injury and hepatic stellate cell activity in mice were used to demonstrate the hepatoprotective characteristics of nanoscale SHXXT decoction.Results: Liver/body weight ratio and serum aspartate and alanine aminotranferase levels were recovered by the nanoscale SHXXT. TIMP-1 gene expression was inhibited and MMP-2 gene expression was accelerated in activated hepatic stellate cells.Conclusion: Nanoscale SHXXT decoction prepared in room temperature water could have preserved hepatoprotective ability. The results of this study indicate that nanoscale SHXXT could be extracted easily. The simple preparation of this herbal decoction is more convenient and energy-efficient.Keywords: Chinese herb medicine, San-Huang-Xie-Xin-Tang, nanoparticle, liver fibrosis&nbsp;
format	article
author	Huang S Chang SJ Yang M Chen JJ Chang WH
author_facet	Huang S Chang SJ Yang M Chen JJ Chang WH
author_sort	Huang S
title	Nanoscale hepatoprotective herbal decoction attenuates hepatic stellate cell activity and chloroform-induced liver damage in mice
title_short	Nanoscale hepatoprotective herbal decoction attenuates hepatic stellate cell activity and chloroform-induced liver damage in mice
title_full	Nanoscale hepatoprotective herbal decoction attenuates hepatic stellate cell activity and chloroform-induced liver damage in mice
title_fullStr	Nanoscale hepatoprotective herbal decoction attenuates hepatic stellate cell activity and chloroform-induced liver damage in mice
title_full_unstemmed	Nanoscale hepatoprotective herbal decoction attenuates hepatic stellate cell activity and chloroform-induced liver damage in mice
title_sort	nanoscale hepatoprotective herbal decoction attenuates hepatic stellate cell activity and chloroform-induced liver damage in mice
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/cb166e47384b4d34a29fc2ea7b37a09f
work_keys_str_mv	AT huangs nanoscalehepatoprotectiveherbaldecoctionattenuateshepaticstellatecellactivityandchloroforminducedliverdamageinmice AT changsj nanoscalehepatoprotectiveherbaldecoctionattenuateshepaticstellatecellactivityandchloroforminducedliverdamageinmice AT yangm nanoscalehepatoprotectiveherbaldecoctionattenuateshepaticstellatecellactivityandchloroforminducedliverdamageinmice AT chenjj nanoscalehepatoprotectiveherbaldecoctionattenuateshepaticstellatecellactivityandchloroforminducedliverdamageinmice AT changwh nanoscalehepatoprotectiveherbaldecoctionattenuateshepaticstellatecellactivityandchloroforminducedliverdamageinmice
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Nanoscale hepatoprotective herbal decoction attenuates hepatic stellate cell activity and chloroform-induced liver damage in mice

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