Usefulness of Xpert® Carba-R on enrichment broth for the early detection of carbapenemase-producing Enterobacterales

ABSTRACT: Early detection of patients colonized with carbapenemase-producing Enterobacterales is crucial to limit their spread. Molecular biology tests are rapid but might miss low-level carriage. Culture-based methods using enrichment are cheap and detect low-level carriage but cause delay. Two cli...

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Autores principales:	Delphine Girlich, Souad Ouzani, Isabelle Langlois, Nicolas Fortineau, Thierry Naas, Laurent Dortet
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	CPE Screening Rectal swabs Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/cb1800428f7f4c6fa9b24638269a5b0b
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spelling	oai:doaj.org-article:cb1800428f7f4c6fa9b24638269a5b0b2021-11-30T04:14:18ZUsefulness of Xpert® Carba-R on enrichment broth for the early detection of carbapenemase-producing Enterobacterales1201-971210.1016/j.ijid.2021.09.031https://doaj.org/article/cb1800428f7f4c6fa9b24638269a5b0b2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221007402https://doaj.org/toc/1201-9712ABSTRACT: Early detection of patients colonized with carbapenemase-producing Enterobacterales is crucial to limit their spread. Molecular biology tests are rapid but might miss low-level carriage. Culture-based methods using enrichment are cheap and detect low-level carriage but cause delay. Two clinical cases are reported, which demonstrated that molecular biology (Xpert® Carb-R) on enriched broth cumulates advantages of both strategies. In both cases, this strategy enabled early detection of patients colonized at low-level with carbapenemase-producing Enterobacterales because it saved 24 hours in detection time.Delphine GirlichSouad OuzaniIsabelle LangloisNicolas FortineauThierry NaasLaurent DortetElsevierarticleCPEScreeningRectal swabsInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 112, Iss , Pp 183-185 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CPE Screening Rectal swabs Infectious and parasitic diseases RC109-216
spellingShingle	CPE Screening Rectal swabs Infectious and parasitic diseases RC109-216 Delphine Girlich Souad Ouzani Isabelle Langlois Nicolas Fortineau Thierry Naas Laurent Dortet Usefulness of Xpert® Carba-R on enrichment broth for the early detection of carbapenemase-producing Enterobacterales
description	ABSTRACT: Early detection of patients colonized with carbapenemase-producing Enterobacterales is crucial to limit their spread. Molecular biology tests are rapid but might miss low-level carriage. Culture-based methods using enrichment are cheap and detect low-level carriage but cause delay. Two clinical cases are reported, which demonstrated that molecular biology (Xpert® Carb-R) on enriched broth cumulates advantages of both strategies. In both cases, this strategy enabled early detection of patients colonized at low-level with carbapenemase-producing Enterobacterales because it saved 24 hours in detection time.
format	article
author	Delphine Girlich Souad Ouzani Isabelle Langlois Nicolas Fortineau Thierry Naas Laurent Dortet
author_facet	Delphine Girlich Souad Ouzani Isabelle Langlois Nicolas Fortineau Thierry Naas Laurent Dortet
author_sort	Delphine Girlich
title	Usefulness of Xpert® Carba-R on enrichment broth for the early detection of carbapenemase-producing Enterobacterales
title_short	Usefulness of Xpert® Carba-R on enrichment broth for the early detection of carbapenemase-producing Enterobacterales
title_full	Usefulness of Xpert® Carba-R on enrichment broth for the early detection of carbapenemase-producing Enterobacterales
title_fullStr	Usefulness of Xpert® Carba-R on enrichment broth for the early detection of carbapenemase-producing Enterobacterales
title_full_unstemmed	Usefulness of Xpert® Carba-R on enrichment broth for the early detection of carbapenemase-producing Enterobacterales
title_sort	usefulness of xpert® carba-r on enrichment broth for the early detection of carbapenemase-producing enterobacterales
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/cb1800428f7f4c6fa9b24638269a5b0b
work_keys_str_mv	AT delphinegirlich usefulnessofxpertcarbaronenrichmentbrothfortheearlydetectionofcarbapenemaseproducingenterobacterales AT souadouzani usefulnessofxpertcarbaronenrichmentbrothfortheearlydetectionofcarbapenemaseproducingenterobacterales AT isabellelanglois usefulnessofxpertcarbaronenrichmentbrothfortheearlydetectionofcarbapenemaseproducingenterobacterales AT nicolasfortineau usefulnessofxpertcarbaronenrichmentbrothfortheearlydetectionofcarbapenemaseproducingenterobacterales AT thierrynaas usefulnessofxpertcarbaronenrichmentbrothfortheearlydetectionofcarbapenemaseproducingenterobacterales AT laurentdortet usefulnessofxpertcarbaronenrichmentbrothfortheearlydetectionofcarbapenemaseproducingenterobacterales
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Usefulness of Xpert® Carba-R on enrichment broth for the early detection of carbapenemase-producing Enterobacterales

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