Soluble Suppression of Tumorigenicity 2 is Directly Correlated with Glycated Hemoglobin in Individuals with an Average glycemia in the Normal/Prediabetes Range

Amal Hasan,1 Waleed Aldhahi2,3 1Department of Immunology and Microbiology, Dasman Diabetes Institute, Kuwait City, Kuwait; 2Medical Division, Dasman Diabetes Institute, Kuwait City, Kuwait; 3Department of Medicine, Mubarak Al-Kabeer Hospital, Kuwait City, KuwaitCorrespondence: Amal Hasan Email amal....

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Autores principales:	Hasan A, Aldhahi W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	glycated hemoglobin prediabetes soluble suppression of tumorigenicity 2. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/cb185f3232844568b64569c92d25b541
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spelling	oai:doaj.org-article:cb185f3232844568b64569c92d25b5412021-12-02T12:29:41ZSoluble Suppression of Tumorigenicity 2 is Directly Correlated with Glycated Hemoglobin in Individuals with an Average glycemia in the Normal/Prediabetes Range1178-7007https://doaj.org/article/cb185f3232844568b64569c92d25b5412020-08-01T00:00:00Zhttps://www.dovepress.com/soluble-suppression-of-tumorigenicity-2-is-directly-correlated-with-gl-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Amal Hasan,1 Waleed Aldhahi2,3 1Department of Immunology and Microbiology, Dasman Diabetes Institute, Kuwait City, Kuwait; 2Medical Division, Dasman Diabetes Institute, Kuwait City, Kuwait; 3Department of Medicine, Mubarak Al-Kabeer Hospital, Kuwait City, KuwaitCorrespondence: Amal Hasan Email amal.hasan@dasmaninstitute.orgPurpose: Cardiovascular disease can be detected in individuals with prediabetes. The purpose of this study was to determine whether soluble suppression of tumorigenicity 2 (sST2), which is elevated in cardiovascular disease and/or type 2 diabetes, is correlated with glycated haemoglobin in individuals with glycemia in the normal/prediabetes range.Patients and Methods: The anthropometric, biochemical and metabolic parameters were measured in 30 adults, and the plasma levels of sST2 were quantified.Results: sST2 was directly correlated with glycated hemoglobin in individuals with glycemia in the normal/prediabetes range. Participants who were at the higher end of glycated hemoglobin (5.8– 6.4%) had significantly higher sST2 compared to those at the lower end (≤ 5.5%). Moreover, sST2 was directly correlated with homeostatic model assessment of insulin resistance (HOMA-IR), alkaline phosphatase, and waist circumference. However, the correlation between sST2 and HOMA-IR or waist circumference was lost after adjusting for age, gender or body mass index.Conclusion: Circulating sST2 may be used to establish a cut-off value for cardiometabolic risk/disease in individuals with glycemia in the normal/prediabetes range.Keywords: glycated hemoglobin, prediabetes, soluble suppression of tumorigenicity 2Hasan AAldhahi WDove Medical Pressarticleglycated hemoglobinprediabetessoluble suppression of tumorigenicity 2.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 2711-2718 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	glycated hemoglobin prediabetes soluble suppression of tumorigenicity 2. Specialties of internal medicine RC581-951
spellingShingle	glycated hemoglobin prediabetes soluble suppression of tumorigenicity 2. Specialties of internal medicine RC581-951 Hasan A Aldhahi W Soluble Suppression of Tumorigenicity 2 is Directly Correlated with Glycated Hemoglobin in Individuals with an Average glycemia in the Normal/Prediabetes Range
description	Amal Hasan,1 Waleed Aldhahi2,3 1Department of Immunology and Microbiology, Dasman Diabetes Institute, Kuwait City, Kuwait; 2Medical Division, Dasman Diabetes Institute, Kuwait City, Kuwait; 3Department of Medicine, Mubarak Al-Kabeer Hospital, Kuwait City, KuwaitCorrespondence: Amal Hasan Email amal.hasan@dasmaninstitute.orgPurpose: Cardiovascular disease can be detected in individuals with prediabetes. The purpose of this study was to determine whether soluble suppression of tumorigenicity 2 (sST2), which is elevated in cardiovascular disease and/or type 2 diabetes, is correlated with glycated haemoglobin in individuals with glycemia in the normal/prediabetes range.Patients and Methods: The anthropometric, biochemical and metabolic parameters were measured in 30 adults, and the plasma levels of sST2 were quantified.Results: sST2 was directly correlated with glycated hemoglobin in individuals with glycemia in the normal/prediabetes range. Participants who were at the higher end of glycated hemoglobin (5.8– 6.4%) had significantly higher sST2 compared to those at the lower end (≤ 5.5%). Moreover, sST2 was directly correlated with homeostatic model assessment of insulin resistance (HOMA-IR), alkaline phosphatase, and waist circumference. However, the correlation between sST2 and HOMA-IR or waist circumference was lost after adjusting for age, gender or body mass index.Conclusion: Circulating sST2 may be used to establish a cut-off value for cardiometabolic risk/disease in individuals with glycemia in the normal/prediabetes range.Keywords: glycated hemoglobin, prediabetes, soluble suppression of tumorigenicity 2
format	article
author	Hasan A Aldhahi W
author_facet	Hasan A Aldhahi W
author_sort	Hasan A
title	Soluble Suppression of Tumorigenicity 2 is Directly Correlated with Glycated Hemoglobin in Individuals with an Average glycemia in the Normal/Prediabetes Range
title_short	Soluble Suppression of Tumorigenicity 2 is Directly Correlated with Glycated Hemoglobin in Individuals with an Average glycemia in the Normal/Prediabetes Range
title_full	Soluble Suppression of Tumorigenicity 2 is Directly Correlated with Glycated Hemoglobin in Individuals with an Average glycemia in the Normal/Prediabetes Range
title_fullStr	Soluble Suppression of Tumorigenicity 2 is Directly Correlated with Glycated Hemoglobin in Individuals with an Average glycemia in the Normal/Prediabetes Range
title_full_unstemmed	Soluble Suppression of Tumorigenicity 2 is Directly Correlated with Glycated Hemoglobin in Individuals with an Average glycemia in the Normal/Prediabetes Range
title_sort	soluble suppression of tumorigenicity 2 is directly correlated with glycated hemoglobin in individuals with an average glycemia in the normal/prediabetes range
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/cb185f3232844568b64569c92d25b541
work_keys_str_mv	AT hasana solublesuppressionoftumorigenicity2isdirectlycorrelatedwithglycatedhemoglobininindividualswithanaverageglycemiainthenormalprediabetesrange AT aldhahiw solublesuppressionoftumorigenicity2isdirectlycorrelatedwithglycatedhemoglobininindividualswithanaverageglycemiainthenormalprediabetesrange
_version_	1718394480462135296

Soluble Suppression of Tumorigenicity 2 is Directly Correlated with Glycated Hemoglobin in Individuals with an Average glycemia in the Normal/Prediabetes Range

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