Rapid, Self-driven Liquid Mixing on Open-Surface Microfluidic Platforms

Abstract Self-driven surface micromixers (SDSM) relying on patterned-wettability technology provide an elegant solution for low-cost, point-of-care (POC) devices and lab-on-a-chip (LOC) applications. We present a SDSM fabricated by strategically patterning three wettable wedge-shaped tracks onto a n...

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Autores principales:	Jared M. Morrissette, Pallab Sinha Mahapatra, Aritra Ghosh, Ranjan Ganguly, Constantine M. Megaridis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cb18ef09e34543d5b07b118173e24f36
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spelling	oai:doaj.org-article:cb18ef09e34543d5b07b118173e24f362021-12-02T11:52:31ZRapid, Self-driven Liquid Mixing on Open-Surface Microfluidic Platforms10.1038/s41598-017-01725-02045-2322https://doaj.org/article/cb18ef09e34543d5b07b118173e24f362017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01725-0https://doaj.org/toc/2045-2322Abstract Self-driven surface micromixers (SDSM) relying on patterned-wettability technology provide an elegant solution for low-cost, point-of-care (POC) devices and lab-on-a-chip (LOC) applications. We present a SDSM fabricated by strategically patterning three wettable wedge-shaped tracks onto a non-wettable, flat surface. This SDSM operates by harnessing the wettability contrast and the geometry of the patterns to promote mixing of small liquid volumes (µL droplets) through a combination of coalescence and Laplace pressure-driven flow. Liquid droplets dispensed on two juxtaposed branches are transported to a coalescence station, where they merge after the accumulated volumes exceed a threshold. Further mixing occurs during capillary-driven, advective transport of the combined liquid over the third wettable track. Planar, non-wettable “islands” of different shapes are also laid on this third track to alter the flow in such a way that mixing is augmented. Several SDSM designs, each with a unique combination of island shapes and positions, are tested, providing a greater understanding of the different mixing regimes on these surfaces. The study offers design insights for developing low-cost surface microfluidic mixing devices on open substrates.Jared M. MorrissettePallab Sinha MahapatraAritra GhoshRanjan GangulyConstantine M. MegaridisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jared M. Morrissette Pallab Sinha Mahapatra Aritra Ghosh Ranjan Ganguly Constantine M. Megaridis Rapid, Self-driven Liquid Mixing on Open-Surface Microfluidic Platforms
description	Abstract Self-driven surface micromixers (SDSM) relying on patterned-wettability technology provide an elegant solution for low-cost, point-of-care (POC) devices and lab-on-a-chip (LOC) applications. We present a SDSM fabricated by strategically patterning three wettable wedge-shaped tracks onto a non-wettable, flat surface. This SDSM operates by harnessing the wettability contrast and the geometry of the patterns to promote mixing of small liquid volumes (µL droplets) through a combination of coalescence and Laplace pressure-driven flow. Liquid droplets dispensed on two juxtaposed branches are transported to a coalescence station, where they merge after the accumulated volumes exceed a threshold. Further mixing occurs during capillary-driven, advective transport of the combined liquid over the third wettable track. Planar, non-wettable “islands” of different shapes are also laid on this third track to alter the flow in such a way that mixing is augmented. Several SDSM designs, each with a unique combination of island shapes and positions, are tested, providing a greater understanding of the different mixing regimes on these surfaces. The study offers design insights for developing low-cost surface microfluidic mixing devices on open substrates.
format	article
author	Jared M. Morrissette Pallab Sinha Mahapatra Aritra Ghosh Ranjan Ganguly Constantine M. Megaridis
author_facet	Jared M. Morrissette Pallab Sinha Mahapatra Aritra Ghosh Ranjan Ganguly Constantine M. Megaridis
author_sort	Jared M. Morrissette
title	Rapid, Self-driven Liquid Mixing on Open-Surface Microfluidic Platforms
title_short	Rapid, Self-driven Liquid Mixing on Open-Surface Microfluidic Platforms
title_full	Rapid, Self-driven Liquid Mixing on Open-Surface Microfluidic Platforms
title_fullStr	Rapid, Self-driven Liquid Mixing on Open-Surface Microfluidic Platforms
title_full_unstemmed	Rapid, Self-driven Liquid Mixing on Open-Surface Microfluidic Platforms
title_sort	rapid, self-driven liquid mixing on open-surface microfluidic platforms
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cb18ef09e34543d5b07b118173e24f36
work_keys_str_mv	AT jaredmmorrissette rapidselfdrivenliquidmixingonopensurfacemicrofluidicplatforms AT pallabsinhamahapatra rapidselfdrivenliquidmixingonopensurfacemicrofluidicplatforms AT aritraghosh rapidselfdrivenliquidmixingonopensurfacemicrofluidicplatforms AT ranjanganguly rapidselfdrivenliquidmixingonopensurfacemicrofluidicplatforms AT constantinemmegaridis rapidselfdrivenliquidmixingonopensurfacemicrofluidicplatforms
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Rapid, Self-driven Liquid Mixing on Open-Surface Microfluidic Platforms

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