Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR

Translation of ATF4 mRNA is stimulated during the integrated stress response. Here the authors show that two noncanonical translation initiation factors eIF2D and DENR are required for translational induction of ATF4 mRNA in Drosophila and human cells.

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Autores principales:	Deepika Vasudevan, Sarah D. Neuman, Amy Yang, Lea Lough, Brian Brown, Arash Bashirullah, Timothy Cardozo, Hyung Don Ryoo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cb19d805a6b24e2eacdacbc663f41ff9
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spelling	oai:doaj.org-article:cb19d805a6b24e2eacdacbc663f41ff92021-12-02T18:33:52ZTranslational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR10.1038/s41467-020-18453-12041-1723https://doaj.org/article/cb19d805a6b24e2eacdacbc663f41ff92020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18453-1https://doaj.org/toc/2041-1723Translation of ATF4 mRNA is stimulated during the integrated stress response. Here the authors show that two noncanonical translation initiation factors eIF2D and DENR are required for translational induction of ATF4 mRNA in Drosophila and human cells.Deepika VasudevanSarah D. NeumanAmy YangLea LoughBrian BrownArash BashirullahTimothy CardozoHyung Don RyooNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Deepika Vasudevan Sarah D. Neuman Amy Yang Lea Lough Brian Brown Arash Bashirullah Timothy Cardozo Hyung Don Ryoo Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR
description	Translation of ATF4 mRNA is stimulated during the integrated stress response. Here the authors show that two noncanonical translation initiation factors eIF2D and DENR are required for translational induction of ATF4 mRNA in Drosophila and human cells.
format	article
author	Deepika Vasudevan Sarah D. Neuman Amy Yang Lea Lough Brian Brown Arash Bashirullah Timothy Cardozo Hyung Don Ryoo
author_facet	Deepika Vasudevan Sarah D. Neuman Amy Yang Lea Lough Brian Brown Arash Bashirullah Timothy Cardozo Hyung Don Ryoo
author_sort	Deepika Vasudevan
title	Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR
title_short	Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR
title_full	Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR
title_fullStr	Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR
title_full_unstemmed	Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR
title_sort	translational induction of atf4 during integrated stress response requires noncanonical initiation factors eif2d and denr
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cb19d805a6b24e2eacdacbc663f41ff9
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Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR

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