Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR

Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR

Translation of ATF4 mRNA is stimulated during the integrated stress response. Here the authors show that two noncanonical translation initiation factors eIF2D and DENR are required for translational induction of ATF4 mRNA in Drosophila and human cells.

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Autores principales: Deepika Vasudevan, Sarah D. Neuman, Amy Yang, Lea Lough, Brian Brown, Arash Bashirullah, Timothy Cardozo, Hyung Don Ryoo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/cb19d805a6b24e2eacdacbc663f41ff9
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