Intraoperative Functional Ultrasound Imaging of Human Brain Activity

Abstract The functional mapping of brain activity is essential to perform optimal glioma surgery and to minimize the risk of postoperative deficits. We introduce a new, portable neuroimaging modality of the human brain based on functional ultrasound (fUS) for deep functional cortical mapping. Using...

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Autores principales:	Marion Imbault, Dorian Chauvet, Jean-Luc Gennisson, Laurent Capelle, Mickael Tanter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cb19e08913b5430795da3ef77b7cf10c
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spelling	oai:doaj.org-article:cb19e08913b5430795da3ef77b7cf10c2021-12-02T15:05:33ZIntraoperative Functional Ultrasound Imaging of Human Brain Activity10.1038/s41598-017-06474-82045-2322https://doaj.org/article/cb19e08913b5430795da3ef77b7cf10c2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06474-8https://doaj.org/toc/2045-2322Abstract The functional mapping of brain activity is essential to perform optimal glioma surgery and to minimize the risk of postoperative deficits. We introduce a new, portable neuroimaging modality of the human brain based on functional ultrasound (fUS) for deep functional cortical mapping. Using plane-wave transmissions at an ultrafast frame rate (1 kHz), fUS is performed during surgery to measure transient changes in cerebral blood volume with a high spatiotemporal resolution (250 µm, 1 ms). fUS identifies, maps and differentiates regions of brain activation during task-evoked cortical responses within the depth of a sulcus in both awake and anaesthetized patients.Marion ImbaultDorian ChauvetJean-Luc GennissonLaurent CapelleMickael TanterNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marion Imbault Dorian Chauvet Jean-Luc Gennisson Laurent Capelle Mickael Tanter Intraoperative Functional Ultrasound Imaging of Human Brain Activity
description	Abstract The functional mapping of brain activity is essential to perform optimal glioma surgery and to minimize the risk of postoperative deficits. We introduce a new, portable neuroimaging modality of the human brain based on functional ultrasound (fUS) for deep functional cortical mapping. Using plane-wave transmissions at an ultrafast frame rate (1 kHz), fUS is performed during surgery to measure transient changes in cerebral blood volume with a high spatiotemporal resolution (250 µm, 1 ms). fUS identifies, maps and differentiates regions of brain activation during task-evoked cortical responses within the depth of a sulcus in both awake and anaesthetized patients.
format	article
author	Marion Imbault Dorian Chauvet Jean-Luc Gennisson Laurent Capelle Mickael Tanter
author_facet	Marion Imbault Dorian Chauvet Jean-Luc Gennisson Laurent Capelle Mickael Tanter
author_sort	Marion Imbault
title	Intraoperative Functional Ultrasound Imaging of Human Brain Activity
title_short	Intraoperative Functional Ultrasound Imaging of Human Brain Activity
title_full	Intraoperative Functional Ultrasound Imaging of Human Brain Activity
title_fullStr	Intraoperative Functional Ultrasound Imaging of Human Brain Activity
title_full_unstemmed	Intraoperative Functional Ultrasound Imaging of Human Brain Activity
title_sort	intraoperative functional ultrasound imaging of human brain activity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cb19e08913b5430795da3ef77b7cf10c
work_keys_str_mv	AT marionimbault intraoperativefunctionalultrasoundimagingofhumanbrainactivity AT dorianchauvet intraoperativefunctionalultrasoundimagingofhumanbrainactivity AT jeanlucgennisson intraoperativefunctionalultrasoundimagingofhumanbrainactivity AT laurentcapelle intraoperativefunctionalultrasoundimagingofhumanbrainactivity AT mickaeltanter intraoperativefunctionalultrasoundimagingofhumanbrainactivity
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Intraoperative Functional Ultrasound Imaging of Human Brain Activity

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