Intraoperative Functional Ultrasound Imaging of Human Brain Activity

Intraoperative Functional Ultrasound Imaging of Human Brain Activity

Abstract The functional mapping of brain activity is essential to perform optimal glioma surgery and to minimize the risk of postoperative deficits. We introduce a new, portable neuroimaging modality of the human brain based on functional ultrasound (fUS) for deep functional cortical mapping. Using...

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Main Authors: Marion Imbault, Dorian Chauvet, Jean-Luc Gennisson, Laurent Capelle, Mickael Tanter
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/cb19e08913b5430795da3ef77b7cf10c
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spelling oai:doaj.org-article:cb19e08913b5430795da3ef77b7cf10c2021-12-02T15:05:33ZIntraoperative Functional Ultrasound Imaging of Human Brain Activity10.1038/s41598-017-06474-82045-2322https://doaj.org/article/cb19e08913b5430795da3ef77b7cf10c2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06474-8https://doaj.org/toc/2045-2322Abstract The functional mapping of brain activity is essential to perform optimal glioma surgery and to minimize the risk of postoperative deficits. We introduce a new, portable neuroimaging modality of the human brain based on functional ultrasound (fUS) for deep functional cortical mapping. Using plane-wave transmissions at an ultrafast frame rate (1 kHz), fUS is performed during surgery to measure transient changes in cerebral blood volume with a high spatiotemporal resolution (250 µm, 1 ms). fUS identifies, maps and differentiates regions of brain activation during task-evoked cortical responses within the depth of a sulcus in both awake and anaesthetized patients.Marion ImbaultDorian ChauvetJean-Luc GennissonLaurent CapelleMickael TanterNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Marion Imbault
Dorian Chauvet
Jean-Luc Gennisson
Laurent Capelle
Mickael Tanter
Intraoperative Functional Ultrasound Imaging of Human Brain Activity
description Abstract The functional mapping of brain activity is essential to perform optimal glioma surgery and to minimize the risk of postoperative deficits. We introduce a new, portable neuroimaging modality of the human brain based on functional ultrasound (fUS) for deep functional cortical mapping. Using plane-wave transmissions at an ultrafast frame rate (1 kHz), fUS is performed during surgery to measure transient changes in cerebral blood volume with a high spatiotemporal resolution (250 µm, 1 ms). fUS identifies, maps and differentiates regions of brain activation during task-evoked cortical responses within the depth of a sulcus in both awake and anaesthetized patients.
format article
author Marion Imbault
Dorian Chauvet
Jean-Luc Gennisson
Laurent Capelle
Mickael Tanter
author_facet Marion Imbault
Dorian Chauvet
Jean-Luc Gennisson
Laurent Capelle
Mickael Tanter
author_sort Marion Imbault
title Intraoperative Functional Ultrasound Imaging of Human Brain Activity
title_short Intraoperative Functional Ultrasound Imaging of Human Brain Activity
title_full Intraoperative Functional Ultrasound Imaging of Human Brain Activity
title_fullStr Intraoperative Functional Ultrasound Imaging of Human Brain Activity
title_full_unstemmed Intraoperative Functional Ultrasound Imaging of Human Brain Activity
title_sort intraoperative functional ultrasound imaging of human brain activity
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/cb19e08913b5430795da3ef77b7cf10c
work_keys_str_mv AT marionimbault intraoperativefunctionalultrasoundimagingofhumanbrainactivity
AT dorianchauvet intraoperativefunctionalultrasoundimagingofhumanbrainactivity
AT jeanlucgennisson intraoperativefunctionalultrasoundimagingofhumanbrainactivity
AT laurentcapelle intraoperativefunctionalultrasoundimagingofhumanbrainactivity
AT mickaeltanter intraoperativefunctionalultrasoundimagingofhumanbrainactivity
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