Precise through-space control of an abiotic electrophilic aromatic substitution reaction

Regioselectivity during electrophilic aromatic substitution is typically controlled by substituents on the aryl group. Here the authors report an electrophilic aromatic substitution reaction, wherein remote chiral ester groups direct the electrophile to a precise location on the molecule.

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Bibliographic Details
Main Authors: Kyle E. Murphy, Jessica L. Bocanegra, Xiaoxi Liu, H.-Y. Katharine Chau, Patrick C. Lee, Jianing Li, Severin T. Schneebeli
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
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Online Access:https://doaj.org/article/cb1c33951f5949f3945f2056f03c8208
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