Capturing the primordial Kras mutation initiating urethane carcinogenesis

Why the carcinogen urethane causes only lung tumours driven by a specific oncogenic mutation in just one Ras gene in mice is unclear. Here, the authors capture mutations immediately after urethane exposure and show that the sequence specificity of mutagenesis, transcriptional status, and Ras genetic...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Siqi Li, David M. MacAlpine, Christopher M. Counter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cb1c397ce0c84a8facfee7f5e41cf830
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cb1c397ce0c84a8facfee7f5e41cf830
record_format	dspace
spelling	oai:doaj.org-article:cb1c397ce0c84a8facfee7f5e41cf8302021-12-02T15:33:32ZCapturing the primordial Kras mutation initiating urethane carcinogenesis10.1038/s41467-020-15660-82041-1723https://doaj.org/article/cb1c397ce0c84a8facfee7f5e41cf8302020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15660-8https://doaj.org/toc/2041-1723Why the carcinogen urethane causes only lung tumours driven by a specific oncogenic mutation in just one Ras gene in mice is unclear. Here, the authors capture mutations immediately after urethane exposure and show that the sequence specificity of mutagenesis, transcriptional status, and Ras genetic loci may all contribute to this specificity.Siqi LiDavid M. MacAlpineChristopher M. CounterNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Siqi Li David M. MacAlpine Christopher M. Counter Capturing the primordial Kras mutation initiating urethane carcinogenesis
description	Why the carcinogen urethane causes only lung tumours driven by a specific oncogenic mutation in just one Ras gene in mice is unclear. Here, the authors capture mutations immediately after urethane exposure and show that the sequence specificity of mutagenesis, transcriptional status, and Ras genetic loci may all contribute to this specificity.
format	article
author	Siqi Li David M. MacAlpine Christopher M. Counter
author_facet	Siqi Li David M. MacAlpine Christopher M. Counter
author_sort	Siqi Li
title	Capturing the primordial Kras mutation initiating urethane carcinogenesis
title_short	Capturing the primordial Kras mutation initiating urethane carcinogenesis
title_full	Capturing the primordial Kras mutation initiating urethane carcinogenesis
title_fullStr	Capturing the primordial Kras mutation initiating urethane carcinogenesis
title_full_unstemmed	Capturing the primordial Kras mutation initiating urethane carcinogenesis
title_sort	capturing the primordial kras mutation initiating urethane carcinogenesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cb1c397ce0c84a8facfee7f5e41cf830
work_keys_str_mv	AT siqili capturingtheprimordialkrasmutationinitiatingurethanecarcinogenesis AT davidmmacalpine capturingtheprimordialkrasmutationinitiatingurethanecarcinogenesis AT christophermcounter capturingtheprimordialkrasmutationinitiatingurethanecarcinogenesis
_version_	1718387109219270656

Capturing the primordial Kras mutation initiating urethane carcinogenesis

Ejemplares similares