Corneal endothelial changes after accelerated corneal collagen cross-linking in keratoconus and postLASIK ectasia

Amani E BadawiDepartment of Ophthalmology, Mansoura University, Mansoura, EgyptPurpose: The purpose of this study was to evaluate the effects of accelerated cross-linking (CXL) on corneal endothelium in keratoconus and postlaser-assisted in situ keratomileusis (LASIK) ectasia.Design: This study is a...

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Autor principal:	Badawi AE
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Accelerated CXL Keratoconus post-Lasik ectasia Corneal endothelium Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/cb2222af553d4d15906c67959389fb6e
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spelling	oai:doaj.org-article:cb2222af553d4d15906c67959389fb6e2021-12-02T00:16:23ZCorneal endothelial changes after accelerated corneal collagen cross-linking in keratoconus and postLASIK ectasia1177-5483https://doaj.org/article/cb2222af553d4d15906c67959389fb6e2016-09-01T00:00:00Zhttps://www.dovepress.com/corneal-endothelial-changes--after-accelerated-corneal-collagen-cross--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Amani E BadawiDepartment of Ophthalmology, Mansoura University, Mansoura, EgyptPurpose: The purpose of this study was to evaluate the effects of accelerated cross-linking (CXL) on corneal endothelium in keratoconus and postlaser-assisted in situ keratomileusis (LASIK) ectasia.Design: This study is a prospective nonrandomized controlled study.Setting: This study was conducted in Mansoura Ophthalmic Center (Mansoura University) and Al-Mostakbal Ophthalmic Center, Mansoura, Egypt.Methods: In total, 40 eyes with progressive keratoconus and 10 eyes with postLASIK ectasia were subjected to an accelerated CXL (10 mW/cm2 for 9 minutes). Qualitative and quantitative analyses of the corneal endothelial cells were conducted before CXL and 3, 6, and 12 months after CXL by using a specular microscope (Tomy EM-3000).Results: There was a significant reduction in endothelial cell count particularly at 3 and 6 months postCXL. In addition, the coefficient of variance was also statistically significantly higher at 3 and 6 months postoperatively than the preCXL value. There was a slight change in the percentage of hexagonal cells.Conclusion: The use of accelerated CXL (10 mW/cm2 for 9 minutes) has a transient negative impact on endothelial cell density and/or endothelial morphology.Keywords: keratoconus, postLASIK ectasia, accelerated cross-linking, corneal endotheliumBadawi AEDove Medical PressarticleAccelerated CXLKeratoconuspost-Lasik ectasiaCorneal endotheliumOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 10, Pp 1891-1898 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Accelerated CXL Keratoconus post-Lasik ectasia Corneal endothelium Ophthalmology RE1-994
spellingShingle	Accelerated CXL Keratoconus post-Lasik ectasia Corneal endothelium Ophthalmology RE1-994 Badawi AE Corneal endothelial changes after accelerated corneal collagen cross-linking in keratoconus and postLASIK ectasia
description	Amani E BadawiDepartment of Ophthalmology, Mansoura University, Mansoura, EgyptPurpose: The purpose of this study was to evaluate the effects of accelerated cross-linking (CXL) on corneal endothelium in keratoconus and postlaser-assisted in situ keratomileusis (LASIK) ectasia.Design: This study is a prospective nonrandomized controlled study.Setting: This study was conducted in Mansoura Ophthalmic Center (Mansoura University) and Al-Mostakbal Ophthalmic Center, Mansoura, Egypt.Methods: In total, 40 eyes with progressive keratoconus and 10 eyes with postLASIK ectasia were subjected to an accelerated CXL (10 mW/cm2 for 9 minutes). Qualitative and quantitative analyses of the corneal endothelial cells were conducted before CXL and 3, 6, and 12 months after CXL by using a specular microscope (Tomy EM-3000).Results: There was a significant reduction in endothelial cell count particularly at 3 and 6 months postCXL. In addition, the coefficient of variance was also statistically significantly higher at 3 and 6 months postoperatively than the preCXL value. There was a slight change in the percentage of hexagonal cells.Conclusion: The use of accelerated CXL (10 mW/cm2 for 9 minutes) has a transient negative impact on endothelial cell density and/or endothelial morphology.Keywords: keratoconus, postLASIK ectasia, accelerated cross-linking, corneal endothelium
format	article
author	Badawi AE
author_facet	Badawi AE
author_sort	Badawi AE
title	Corneal endothelial changes after accelerated corneal collagen cross-linking in keratoconus and postLASIK ectasia
title_short	Corneal endothelial changes after accelerated corneal collagen cross-linking in keratoconus and postLASIK ectasia
title_full	Corneal endothelial changes after accelerated corneal collagen cross-linking in keratoconus and postLASIK ectasia
title_fullStr	Corneal endothelial changes after accelerated corneal collagen cross-linking in keratoconus and postLASIK ectasia
title_full_unstemmed	Corneal endothelial changes after accelerated corneal collagen cross-linking in keratoconus and postLASIK ectasia
title_sort	corneal endothelial changes after accelerated corneal collagen cross-linking in keratoconus and postlasik ectasia
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/cb2222af553d4d15906c67959389fb6e
work_keys_str_mv	AT badawiae cornealendothelialchangesafteracceleratedcornealcollagencrosslinkinginkeratoconusandpostlasikectasia
_version_	1718403890922127360

Corneal endothelial changes after accelerated corneal collagen cross-linking in keratoconus and postLASIK ectasia

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