Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection

Here the authors develop mosquito cell lines expressing Zika virus (ZIKV) capsid and perform proteomics experiments retrieving 157 protein interactors, of which they show 8 to act as pro-viral factors, showing the transitional endoplasmic reticulum 94 (TER94) and its human ortholog VCP target ZIKV c...

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Autores principales:	Rommel J. Gestuveo, Jamie Royle, Claire L. Donald, Douglas J. Lamont, Edward C. Hutchinson, Andres Merits, Alain Kohl, Margus Varjak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cb2270c6864b4592bcfcd4b448736403
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id	oai:doaj.org-article:cb2270c6864b4592bcfcd4b448736403
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spelling	oai:doaj.org-article:cb2270c6864b4592bcfcd4b4487364032021-12-02T15:43:16ZAnalysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection10.1038/s41467-021-22966-82041-1723https://doaj.org/article/cb2270c6864b4592bcfcd4b4487364032021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22966-8https://doaj.org/toc/2041-1723Here the authors develop mosquito cell lines expressing Zika virus (ZIKV) capsid and perform proteomics experiments retrieving 157 protein interactors, of which they show 8 to act as pro-viral factors, showing the transitional endoplasmic reticulum 94 (TER94) and its human ortholog VCP target ZIKV capsid to proteasomal degradation to facilitate infection.Rommel J. GestuveoJamie RoyleClaire L. DonaldDouglas J. LamontEdward C. HutchinsonAndres MeritsAlain KohlMargus VarjakNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rommel J. Gestuveo Jamie Royle Claire L. Donald Douglas J. Lamont Edward C. Hutchinson Andres Merits Alain Kohl Margus Varjak Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection
description	Here the authors develop mosquito cell lines expressing Zika virus (ZIKV) capsid and perform proteomics experiments retrieving 157 protein interactors, of which they show 8 to act as pro-viral factors, showing the transitional endoplasmic reticulum 94 (TER94) and its human ortholog VCP target ZIKV capsid to proteasomal degradation to facilitate infection.
format	article
author	Rommel J. Gestuveo Jamie Royle Claire L. Donald Douglas J. Lamont Edward C. Hutchinson Andres Merits Alain Kohl Margus Varjak
author_facet	Rommel J. Gestuveo Jamie Royle Claire L. Donald Douglas J. Lamont Edward C. Hutchinson Andres Merits Alain Kohl Margus Varjak
author_sort	Rommel J. Gestuveo
title	Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection
title_short	Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection
title_full	Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection
title_fullStr	Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection
title_full_unstemmed	Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection
title_sort	analysis of zika virus capsid-aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cb2270c6864b4592bcfcd4b448736403
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Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection

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