Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search

It is not fully understood how XPA interacts with a DNA lesion during nucleotide excision repair. Here, the authors use single molecule analysis to study XPA–DNA interactions, including the DNA bend angle, protein stoichiometry, and diffusive properties during damage search.

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Autores principales:	Emily C. Beckwitt, Sunbok Jang, Isadora Carnaval Detweiler, Jochen Kuper, Florian Sauer, Nina Simon, Johanna Bretzler, Simon C. Watkins, Thomas Carell, Caroline Kisker, Bennett Van Houten
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cb2429af2c074e93843b6cd1c155ebba
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spelling	oai:doaj.org-article:cb2429af2c074e93843b6cd1c155ebba2021-12-02T14:41:02ZSingle molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search10.1038/s41467-020-15168-12041-1723https://doaj.org/article/cb2429af2c074e93843b6cd1c155ebba2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15168-1https://doaj.org/toc/2041-1723It is not fully understood how XPA interacts with a DNA lesion during nucleotide excision repair. Here, the authors use single molecule analysis to study XPA–DNA interactions, including the DNA bend angle, protein stoichiometry, and diffusive properties during damage search.Emily C. BeckwittSunbok JangIsadora Carnaval DetweilerJochen KuperFlorian SauerNina SimonJohanna BretzlerSimon C. WatkinsThomas CarellCaroline KiskerBennett Van HoutenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emily C. Beckwitt Sunbok Jang Isadora Carnaval Detweiler Jochen Kuper Florian Sauer Nina Simon Johanna Bretzler Simon C. Watkins Thomas Carell Caroline Kisker Bennett Van Houten Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search
description	It is not fully understood how XPA interacts with a DNA lesion during nucleotide excision repair. Here, the authors use single molecule analysis to study XPA–DNA interactions, including the DNA bend angle, protein stoichiometry, and diffusive properties during damage search.
format	article
author	Emily C. Beckwitt Sunbok Jang Isadora Carnaval Detweiler Jochen Kuper Florian Sauer Nina Simon Johanna Bretzler Simon C. Watkins Thomas Carell Caroline Kisker Bennett Van Houten
author_facet	Emily C. Beckwitt Sunbok Jang Isadora Carnaval Detweiler Jochen Kuper Florian Sauer Nina Simon Johanna Bretzler Simon C. Watkins Thomas Carell Caroline Kisker Bennett Van Houten
author_sort	Emily C. Beckwitt
title	Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search
title_short	Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search
title_full	Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search
title_fullStr	Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search
title_full_unstemmed	Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search
title_sort	single molecule analysis reveals monomeric xpa bends dna and undergoes episodic linear diffusion during damage search
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/cb2429af2c074e93843b6cd1c155ebba
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Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search

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