Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search

Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search

It is not fully understood how XPA interacts with a DNA lesion during nucleotide excision repair. Here, the authors use single molecule analysis to study XPA–DNA interactions, including the DNA bend angle, protein stoichiometry, and diffusive properties during damage search.

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Autores principales: Emily C. Beckwitt, Sunbok Jang, Isadora Carnaval Detweiler, Jochen Kuper, Florian Sauer, Nina Simon, Johanna Bretzler, Simon C. Watkins, Thomas Carell, Caroline Kisker, Bennett Van Houten
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/cb2429af2c074e93843b6cd1c155ebba
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