Brain network motifs are markers of loss and recovery of consciousness

Abstract Motifs are patterns of inter-connections between nodes of a network, and have been investigated as building blocks of directed networks. This study explored the re-organization of 3-node motifs during loss and recovery of consciousness. Nine healthy subjects underwent a 3-h anesthetic proto...

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Autores principales:	Catherine Duclos, Danielle Nadin, Yacine Mahdid, Vijay Tarnal, Paul Picton, Giancarlo Vanini, Goodarz Golmirzaie, Ellen Janke, Michael S. Avidan, Max B. Kelz, George A. Mashour, Stefanie Blain-Moraes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cb25a4d6c7734d16b91703c625e51482
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spelling	oai:doaj.org-article:cb25a4d6c7734d16b91703c625e514822021-12-02T10:54:23ZBrain network motifs are markers of loss and recovery of consciousness10.1038/s41598-021-83482-92045-2322https://doaj.org/article/cb25a4d6c7734d16b91703c625e514822021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83482-9https://doaj.org/toc/2045-2322Abstract Motifs are patterns of inter-connections between nodes of a network, and have been investigated as building blocks of directed networks. This study explored the re-organization of 3-node motifs during loss and recovery of consciousness. Nine healthy subjects underwent a 3-h anesthetic protocol while 128-channel electroencephalography (EEG) was recorded. In the alpha (8–13 Hz) band, 5-min epochs of EEG were extracted for: Baseline; Induction; Unconscious; 30-, 10- and 5-min pre-recovery of responsiveness; 30- and 180-min post-recovery of responsiveness. We constructed a functional brain network using the weighted and directed phase lag index, on which we calculated the frequency and topology of 3-node motifs. Three motifs (motifs 1, 2 and 5) were significantly present across participants and epochs, when compared to random networks (p < 0.05). The topology of motifs 1 and 5 changed significantly between responsive and unresponsive epochs (p-values < 0.01; Kendall’s W = 0.664 (motif 1) and 0.529 (motif 5)). Motif 1 was constituted of long-range chain-like connections, while motif 5 was constituted of short-range, loop-like connections. Our results suggest that anesthetic-induced unconsciousness is associated with a topological re-organization of network motifs. As motif topological re-organization may precede (motif 5) or accompany (motif 1) the return of responsiveness, motifs could contribute to the understanding of the neural correlates of consciousness.Catherine DuclosDanielle NadinYacine MahdidVijay TarnalPaul PictonGiancarlo VaniniGoodarz GolmirzaieEllen JankeMichael S. AvidanMax B. KelzGeorge A. MashourStefanie Blain-MoraesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Catherine Duclos Danielle Nadin Yacine Mahdid Vijay Tarnal Paul Picton Giancarlo Vanini Goodarz Golmirzaie Ellen Janke Michael S. Avidan Max B. Kelz George A. Mashour Stefanie Blain-Moraes Brain network motifs are markers of loss and recovery of consciousness
description	Abstract Motifs are patterns of inter-connections between nodes of a network, and have been investigated as building blocks of directed networks. This study explored the re-organization of 3-node motifs during loss and recovery of consciousness. Nine healthy subjects underwent a 3-h anesthetic protocol while 128-channel electroencephalography (EEG) was recorded. In the alpha (8–13 Hz) band, 5-min epochs of EEG were extracted for: Baseline; Induction; Unconscious; 30-, 10- and 5-min pre-recovery of responsiveness; 30- and 180-min post-recovery of responsiveness. We constructed a functional brain network using the weighted and directed phase lag index, on which we calculated the frequency and topology of 3-node motifs. Three motifs (motifs 1, 2 and 5) were significantly present across participants and epochs, when compared to random networks (p < 0.05). The topology of motifs 1 and 5 changed significantly between responsive and unresponsive epochs (p-values < 0.01; Kendall’s W = 0.664 (motif 1) and 0.529 (motif 5)). Motif 1 was constituted of long-range chain-like connections, while motif 5 was constituted of short-range, loop-like connections. Our results suggest that anesthetic-induced unconsciousness is associated with a topological re-organization of network motifs. As motif topological re-organization may precede (motif 5) or accompany (motif 1) the return of responsiveness, motifs could contribute to the understanding of the neural correlates of consciousness.
format	article
author	Catherine Duclos Danielle Nadin Yacine Mahdid Vijay Tarnal Paul Picton Giancarlo Vanini Goodarz Golmirzaie Ellen Janke Michael S. Avidan Max B. Kelz George A. Mashour Stefanie Blain-Moraes
author_facet	Catherine Duclos Danielle Nadin Yacine Mahdid Vijay Tarnal Paul Picton Giancarlo Vanini Goodarz Golmirzaie Ellen Janke Michael S. Avidan Max B. Kelz George A. Mashour Stefanie Blain-Moraes
author_sort	Catherine Duclos
title	Brain network motifs are markers of loss and recovery of consciousness
title_short	Brain network motifs are markers of loss and recovery of consciousness
title_full	Brain network motifs are markers of loss and recovery of consciousness
title_fullStr	Brain network motifs are markers of loss and recovery of consciousness
title_full_unstemmed	Brain network motifs are markers of loss and recovery of consciousness
title_sort	brain network motifs are markers of loss and recovery of consciousness
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cb25a4d6c7734d16b91703c625e51482
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_version_	1718396494082473984

Brain network motifs are markers of loss and recovery of consciousness

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