Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies

Ulcerative colitis (UC) is a chronic autoimmune disorder affecting the colonic mucosa. UC is a subtype of inflammatory bowel disease along with Crohn’s disease and presents with varying extraintestinal manifestations. No single etiology for UC has been found, but a combination of genetic and environ...

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Autores principales:	Jelena Popov, Valentina Caputi, Nandini Nandeesha, David Avelar Rodriguez, Nikhil Pai
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ulcerative colitis inflammatory bowel diseases pediatrics FMT probiotics synbiotics Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/cb2747d8247e44228cba0504a9af87c6
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spelling	oai:doaj.org-article:cb2747d8247e44228cba0504a9af87c62021-11-11T16:50:21ZMicrobiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies10.3390/ijms2221113651422-00671661-6596https://doaj.org/article/cb2747d8247e44228cba0504a9af87c62021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11365https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Ulcerative colitis (UC) is a chronic autoimmune disorder affecting the colonic mucosa. UC is a subtype of inflammatory bowel disease along with Crohn’s disease and presents with varying extraintestinal manifestations. No single etiology for UC has been found, but a combination of genetic and environmental factors is suspected. Research has focused on the role of intestinal dysbiosis in the pathogenesis of UC, including the effects of dysbiosis on the integrity of the colonic mucosal barrier, priming and regulation of the host immune system, chronic inflammation, and progression to tumorigenesis. Characterization of key microbial taxa and their implications in the pathogenesis of UC and colitis-associated cancer (CAC) may present opportunities for modulating intestinal inflammation through microbial-targeted therapies. In this review, we discuss the microbiota-immune crosstalk in UC and CAC, as well as the evolution of microbiota-based therapies.Jelena PopovValentina CaputiNandini NandeeshaDavid Avelar RodriguezNikhil PaiMDPI AGarticleulcerative colitisinflammatory bowel diseasespediatricsFMTprobioticssynbioticsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11365, p 11365 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ulcerative colitis inflammatory bowel diseases pediatrics FMT probiotics synbiotics Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	ulcerative colitis inflammatory bowel diseases pediatrics FMT probiotics synbiotics Biology (General) QH301-705.5 Chemistry QD1-999 Jelena Popov Valentina Caputi Nandini Nandeesha David Avelar Rodriguez Nikhil Pai Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies
description	Ulcerative colitis (UC) is a chronic autoimmune disorder affecting the colonic mucosa. UC is a subtype of inflammatory bowel disease along with Crohn’s disease and presents with varying extraintestinal manifestations. No single etiology for UC has been found, but a combination of genetic and environmental factors is suspected. Research has focused on the role of intestinal dysbiosis in the pathogenesis of UC, including the effects of dysbiosis on the integrity of the colonic mucosal barrier, priming and regulation of the host immune system, chronic inflammation, and progression to tumorigenesis. Characterization of key microbial taxa and their implications in the pathogenesis of UC and colitis-associated cancer (CAC) may present opportunities for modulating intestinal inflammation through microbial-targeted therapies. In this review, we discuss the microbiota-immune crosstalk in UC and CAC, as well as the evolution of microbiota-based therapies.
format	article
author	Jelena Popov Valentina Caputi Nandini Nandeesha David Avelar Rodriguez Nikhil Pai
author_facet	Jelena Popov Valentina Caputi Nandini Nandeesha David Avelar Rodriguez Nikhil Pai
author_sort	Jelena Popov
title	Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies
title_short	Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies
title_full	Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies
title_fullStr	Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies
title_full_unstemmed	Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies
title_sort	microbiota-immune interactions in ulcerative colitis and colitis associated cancer and emerging microbiota-based therapies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cb2747d8247e44228cba0504a9af87c6
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Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies

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