Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies

Ulcerative colitis (UC) is a chronic autoimmune disorder affecting the colonic mucosa. UC is a subtype of inflammatory bowel disease along with Crohn’s disease and presents with varying extraintestinal manifestations. No single etiology for UC has been found, but a combination of genetic and environ...

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Autores principales: Jelena Popov, Valentina Caputi, Nandini Nandeesha, David Avelar Rodriguez, Nikhil Pai
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/cb2747d8247e44228cba0504a9af87c6
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spelling oai:doaj.org-article:cb2747d8247e44228cba0504a9af87c62021-11-11T16:50:21ZMicrobiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies10.3390/ijms2221113651422-00671661-6596https://doaj.org/article/cb2747d8247e44228cba0504a9af87c62021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11365https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Ulcerative colitis (UC) is a chronic autoimmune disorder affecting the colonic mucosa. UC is a subtype of inflammatory bowel disease along with Crohn’s disease and presents with varying extraintestinal manifestations. No single etiology for UC has been found, but a combination of genetic and environmental factors is suspected. Research has focused on the role of intestinal dysbiosis in the pathogenesis of UC, including the effects of dysbiosis on the integrity of the colonic mucosal barrier, priming and regulation of the host immune system, chronic inflammation, and progression to tumorigenesis. Characterization of key microbial taxa and their implications in the pathogenesis of UC and colitis-associated cancer (CAC) may present opportunities for modulating intestinal inflammation through microbial-targeted therapies. In this review, we discuss the microbiota-immune crosstalk in UC and CAC, as well as the evolution of microbiota-based therapies.Jelena PopovValentina CaputiNandini NandeeshaDavid Avelar RodriguezNikhil PaiMDPI AGarticleulcerative colitisinflammatory bowel diseasespediatricsFMTprobioticssynbioticsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11365, p 11365 (2021)
institution DOAJ
collection DOAJ
language EN
topic ulcerative colitis
inflammatory bowel diseases
pediatrics
FMT
probiotics
synbiotics
Biology (General)
QH301-705.5
Chemistry
QD1-999
spellingShingle ulcerative colitis
inflammatory bowel diseases
pediatrics
FMT
probiotics
synbiotics
Biology (General)
QH301-705.5
Chemistry
QD1-999
Jelena Popov
Valentina Caputi
Nandini Nandeesha
David Avelar Rodriguez
Nikhil Pai
Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies
description Ulcerative colitis (UC) is a chronic autoimmune disorder affecting the colonic mucosa. UC is a subtype of inflammatory bowel disease along with Crohn’s disease and presents with varying extraintestinal manifestations. No single etiology for UC has been found, but a combination of genetic and environmental factors is suspected. Research has focused on the role of intestinal dysbiosis in the pathogenesis of UC, including the effects of dysbiosis on the integrity of the colonic mucosal barrier, priming and regulation of the host immune system, chronic inflammation, and progression to tumorigenesis. Characterization of key microbial taxa and their implications in the pathogenesis of UC and colitis-associated cancer (CAC) may present opportunities for modulating intestinal inflammation through microbial-targeted therapies. In this review, we discuss the microbiota-immune crosstalk in UC and CAC, as well as the evolution of microbiota-based therapies.
format article
author Jelena Popov
Valentina Caputi
Nandini Nandeesha
David Avelar Rodriguez
Nikhil Pai
author_facet Jelena Popov
Valentina Caputi
Nandini Nandeesha
David Avelar Rodriguez
Nikhil Pai
author_sort Jelena Popov
title Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies
title_short Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies
title_full Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies
title_fullStr Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies
title_full_unstemmed Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies
title_sort microbiota-immune interactions in ulcerative colitis and colitis associated cancer and emerging microbiota-based therapies
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/cb2747d8247e44228cba0504a9af87c6
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AT valentinacaputi microbiotaimmuneinteractionsinulcerativecolitisandcolitisassociatedcancerandemergingmicrobiotabasedtherapies
AT nandininandeesha microbiotaimmuneinteractionsinulcerativecolitisandcolitisassociatedcancerandemergingmicrobiotabasedtherapies
AT davidavelarrodriguez microbiotaimmuneinteractionsinulcerativecolitisandcolitisassociatedcancerandemergingmicrobiotabasedtherapies
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