Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies
Ulcerative colitis (UC) is a chronic autoimmune disorder affecting the colonic mucosa. UC is a subtype of inflammatory bowel disease along with Crohn’s disease and presents with varying extraintestinal manifestations. No single etiology for UC has been found, but a combination of genetic and environ...
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MDPI AG
2021
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oai:doaj.org-article:cb2747d8247e44228cba0504a9af87c62021-11-11T16:50:21ZMicrobiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies10.3390/ijms2221113651422-00671661-6596https://doaj.org/article/cb2747d8247e44228cba0504a9af87c62021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11365https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Ulcerative colitis (UC) is a chronic autoimmune disorder affecting the colonic mucosa. UC is a subtype of inflammatory bowel disease along with Crohn’s disease and presents with varying extraintestinal manifestations. No single etiology for UC has been found, but a combination of genetic and environmental factors is suspected. Research has focused on the role of intestinal dysbiosis in the pathogenesis of UC, including the effects of dysbiosis on the integrity of the colonic mucosal barrier, priming and regulation of the host immune system, chronic inflammation, and progression to tumorigenesis. Characterization of key microbial taxa and their implications in the pathogenesis of UC and colitis-associated cancer (CAC) may present opportunities for modulating intestinal inflammation through microbial-targeted therapies. In this review, we discuss the microbiota-immune crosstalk in UC and CAC, as well as the evolution of microbiota-based therapies.Jelena PopovValentina CaputiNandini NandeeshaDavid Avelar RodriguezNikhil PaiMDPI AGarticleulcerative colitisinflammatory bowel diseasespediatricsFMTprobioticssynbioticsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11365, p 11365 (2021) |
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ulcerative colitis inflammatory bowel diseases pediatrics FMT probiotics synbiotics Biology (General) QH301-705.5 Chemistry QD1-999 |
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ulcerative colitis inflammatory bowel diseases pediatrics FMT probiotics synbiotics Biology (General) QH301-705.5 Chemistry QD1-999 Jelena Popov Valentina Caputi Nandini Nandeesha David Avelar Rodriguez Nikhil Pai Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies |
description |
Ulcerative colitis (UC) is a chronic autoimmune disorder affecting the colonic mucosa. UC is a subtype of inflammatory bowel disease along with Crohn’s disease and presents with varying extraintestinal manifestations. No single etiology for UC has been found, but a combination of genetic and environmental factors is suspected. Research has focused on the role of intestinal dysbiosis in the pathogenesis of UC, including the effects of dysbiosis on the integrity of the colonic mucosal barrier, priming and regulation of the host immune system, chronic inflammation, and progression to tumorigenesis. Characterization of key microbial taxa and their implications in the pathogenesis of UC and colitis-associated cancer (CAC) may present opportunities for modulating intestinal inflammation through microbial-targeted therapies. In this review, we discuss the microbiota-immune crosstalk in UC and CAC, as well as the evolution of microbiota-based therapies. |
format |
article |
author |
Jelena Popov Valentina Caputi Nandini Nandeesha David Avelar Rodriguez Nikhil Pai |
author_facet |
Jelena Popov Valentina Caputi Nandini Nandeesha David Avelar Rodriguez Nikhil Pai |
author_sort |
Jelena Popov |
title |
Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies |
title_short |
Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies |
title_full |
Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies |
title_fullStr |
Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies |
title_full_unstemmed |
Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies |
title_sort |
microbiota-immune interactions in ulcerative colitis and colitis associated cancer and emerging microbiota-based therapies |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doaj.org/article/cb2747d8247e44228cba0504a9af87c6 |
work_keys_str_mv |
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