Structure–Function Correlation Using OCT Angiography And Microperimetry In Diabetic Retinopathy

Marta Alonso-Plasencia,1 Rodrigo Abreu-González,1 Mario Alberto Gómez-Culebras2 1Ophthalmology Department, University Hospital of Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain; 2Pediatric Surgery Department, University Hospital of Nuestra Señ...

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Autores principales:	Alonso-Plasencia M, Abreu-González R, Gómez-Culebras MA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	diabetic retinopathy vessel density retinal sensitity Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/cb2875d825ff4634ac65b28b4daba6e1
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spelling	oai:doaj.org-article:cb2875d825ff4634ac65b28b4daba6e12021-12-02T01:06:42ZStructure–Function Correlation Using OCT Angiography And Microperimetry In Diabetic Retinopathy1177-5483https://doaj.org/article/cb2875d825ff4634ac65b28b4daba6e12019-11-01T00:00:00Zhttps://www.dovepress.com/structur-function-correlation-using-oct-angiography-and-microperimetry-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Marta Alonso-Plasencia,1 Rodrigo Abreu-González,1 Mario Alberto Gómez-Culebras2 1Ophthalmology Department, University Hospital of Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain; 2Pediatric Surgery Department, University Hospital of Nuestra Señora de Candelaria, Santa Cruz de Tenerife, SpainCorrespondence: Marta Alonso-Plasencia Ophthalmology Department, University Hospital of Nuestra Señora de Candelaria, Calle Álvaro Rodríguez López, 10, Portal B2, Piso 1ºi, Santa Cruz de Tenerife 38003, SpainTel +34616034090Fax +34922600530Email martaalonsopla@gmail.comPurpose: To evaluate macular vasculature in diabetic retinopathy (DR) with optical coherence tomography angiography (OCTA) and to correlate vessel density (VD) with retinal sensitivity (RS) as a way to assess structural and functional findings in DR.Design: Prospective observational cross-sectional study.Methods: Diabetic patients with DR but no clinically significant diabetic macular edema (DME) and healthy subjects were included in this study. All of them underwent comprehensive ophthalmic examination, best corrected visual acuity (BCVA), OCTA with RS-3000 Advance AngioScan (Nidek, Gamagori, Japan) and microperimetry with MP-3 (Nidek, Gamagori, Japan). Retinal vascular density measured by OCT angiography in 9 areas was correlated with RS in the same 9 areas by Spearman correlation.Results: In this study, 50 subjects were enrolled: 25 eyes of diabetic patients with DR and 25 eyes of non-diabetic subjects. Diabetic patients mean age was 51.88±13.62 years; non-diabetic subjects were 43.48±13.42 years. The BCVA was 20/25 in the diabetic group and 20/20 in the non-diabetic group. Mean RS was decreased in the DR group (27.68±2.71 dB) compared to the non-diabetic group (31.68±1.46 dB) (p<0.05) and in the 9 studied areas (p<0.05). Mean VD was decreased in the DR group compared to non-diabetics (p<0.05) and in 7 of the 9 areas (except temporal superior and inferior squares) (p<0.05). Correlations by areas between VD and RS were assessed, we found moderate correlation in the area temporal to the fovea (r=0.501, p=0.01) in the DR group but not in the non-diabetic subjects. There were no other statistical significant correlations with this pattern.Conclusion: DR without DME results in a retinal VD decreased that might be the cause of a reduction of RS in one of the studied areas. Microangiopathic changes are correlated with microperimetry sensitivity drop in the temporal to the fovea grid but not in the other studied grids.Keywords: diabetic retinopathy, vessel density, retinal sensitivityAlonso-Plasencia MAbreu-González RGómez-Culebras MADove Medical Pressarticlediabetic retinopathyvessel densityretinal sensitityOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 2181-2188 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic retinopathy vessel density retinal sensitity Ophthalmology RE1-994
spellingShingle	diabetic retinopathy vessel density retinal sensitity Ophthalmology RE1-994 Alonso-Plasencia M Abreu-González R Gómez-Culebras MA Structure–Function Correlation Using OCT Angiography And Microperimetry In Diabetic Retinopathy
description	Marta Alonso-Plasencia,1 Rodrigo Abreu-González,1 Mario Alberto Gómez-Culebras2 1Ophthalmology Department, University Hospital of Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain; 2Pediatric Surgery Department, University Hospital of Nuestra Señora de Candelaria, Santa Cruz de Tenerife, SpainCorrespondence: Marta Alonso-Plasencia Ophthalmology Department, University Hospital of Nuestra Señora de Candelaria, Calle Álvaro Rodríguez López, 10, Portal B2, Piso 1ºi, Santa Cruz de Tenerife 38003, SpainTel +34616034090Fax +34922600530Email martaalonsopla@gmail.comPurpose: To evaluate macular vasculature in diabetic retinopathy (DR) with optical coherence tomography angiography (OCTA) and to correlate vessel density (VD) with retinal sensitivity (RS) as a way to assess structural and functional findings in DR.Design: Prospective observational cross-sectional study.Methods: Diabetic patients with DR but no clinically significant diabetic macular edema (DME) and healthy subjects were included in this study. All of them underwent comprehensive ophthalmic examination, best corrected visual acuity (BCVA), OCTA with RS-3000 Advance AngioScan (Nidek, Gamagori, Japan) and microperimetry with MP-3 (Nidek, Gamagori, Japan). Retinal vascular density measured by OCT angiography in 9 areas was correlated with RS in the same 9 areas by Spearman correlation.Results: In this study, 50 subjects were enrolled: 25 eyes of diabetic patients with DR and 25 eyes of non-diabetic subjects. Diabetic patients mean age was 51.88±13.62 years; non-diabetic subjects were 43.48±13.42 years. The BCVA was 20/25 in the diabetic group and 20/20 in the non-diabetic group. Mean RS was decreased in the DR group (27.68±2.71 dB) compared to the non-diabetic group (31.68±1.46 dB) (p<0.05) and in the 9 studied areas (p<0.05). Mean VD was decreased in the DR group compared to non-diabetics (p<0.05) and in 7 of the 9 areas (except temporal superior and inferior squares) (p<0.05). Correlations by areas between VD and RS were assessed, we found moderate correlation in the area temporal to the fovea (r=0.501, p=0.01) in the DR group but not in the non-diabetic subjects. There were no other statistical significant correlations with this pattern.Conclusion: DR without DME results in a retinal VD decreased that might be the cause of a reduction of RS in one of the studied areas. Microangiopathic changes are correlated with microperimetry sensitivity drop in the temporal to the fovea grid but not in the other studied grids.Keywords: diabetic retinopathy, vessel density, retinal sensitivity
format	article
author	Alonso-Plasencia M Abreu-González R Gómez-Culebras MA
author_facet	Alonso-Plasencia M Abreu-González R Gómez-Culebras MA
author_sort	Alonso-Plasencia M
title	Structure–Function Correlation Using OCT Angiography And Microperimetry In Diabetic Retinopathy
title_short	Structure–Function Correlation Using OCT Angiography And Microperimetry In Diabetic Retinopathy
title_full	Structure–Function Correlation Using OCT Angiography And Microperimetry In Diabetic Retinopathy
title_fullStr	Structure–Function Correlation Using OCT Angiography And Microperimetry In Diabetic Retinopathy
title_full_unstemmed	Structure–Function Correlation Using OCT Angiography And Microperimetry In Diabetic Retinopathy
title_sort	structure–function correlation using oct angiography and microperimetry in diabetic retinopathy
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/cb2875d825ff4634ac65b28b4daba6e1
work_keys_str_mv	AT alonsoplasenciam structurefunctioncorrelationusingoctangiographyandmicroperimetryindiabeticretinopathy AT abreugonzalezr structurefunctioncorrelationusingoctangiographyandmicroperimetryindiabeticretinopathy AT gomezculebrasma structurefunctioncorrelationusingoctangiographyandmicroperimetryindiabeticretinopathy
_version_	1718403344853106688

Structure–Function Correlation Using OCT Angiography And Microperimetry In Diabetic Retinopathy

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