Integrated analysis highlights APC11 protein expression as a likely new independent predictive marker for colorectal cancer

Abstract After a diagnosis of colorectal cancer (CRC), approximately 50% of patients will present distant metastasis. Although significant progress has been made in treatments, most of them will die from the disease. We investigated the predictive and prognostic potential of APC11, the catalytic sub...

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Autores principales:	Youenn Drouet, Isabelle Treilleux, Alain Viari, Sophie Léon, Mojgan Devouassoux-Shisheboran, Nicolas Voirin, Christelle de la Fouchardière, Brigitte Manship, Alain Puisieux, Christine Lasset, Caroline Moyret-Lalle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cb2b22da5cf344ad9f5d72362d671496
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spelling	oai:doaj.org-article:cb2b22da5cf344ad9f5d72362d6714962021-12-02T11:40:24ZIntegrated analysis highlights APC11 protein expression as a likely new independent predictive marker for colorectal cancer10.1038/s41598-018-25631-12045-2322https://doaj.org/article/cb2b22da5cf344ad9f5d72362d6714962018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25631-1https://doaj.org/toc/2045-2322Abstract After a diagnosis of colorectal cancer (CRC), approximately 50% of patients will present distant metastasis. Although significant progress has been made in treatments, most of them will die from the disease. We investigated the predictive and prognostic potential of APC11, the catalytic subunit of APC/C, which has never been examined in the context of CRC. The expression of APC11 was assessed in CRC cell lines, in tissue microarrays (TMAs) and in public datasets. Overexpression of APC11 mRNA was associated with chromosomal instability, lymphovascular invasion and residual tumor. Regression models accounting for the effects of well-known protein markers highlighted association of APC11 protein expression with residual tumor (odds ratio: OR = 6.51; 95% confidence intervals: CI = 1.54–27.59; P = 0.012) and metastasis at diagnosis (OR = 3.87; 95% CI = 1.20–2.45; P = 0.024). Overexpression of APC11 protein was also associated with worse distant relapse-free survival (hazard ratio: HR = 2.60; 95% CI = 1.26–5.37; P = 0.01) and worse overall survival (HR = 2.69; 95% CI = 1.31–5.51; P = 0.007). APC11 overexpression in primary CRC thus represents a potentially novel theranostic marker of metastatic CRC.Youenn DrouetIsabelle TreilleuxAlain ViariSophie LéonMojgan Devouassoux-ShisheboranNicolas VoirinChristelle de la FouchardièreBrigitte ManshipAlain PuisieuxChristine LassetCaroline Moyret-LalleNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Youenn Drouet Isabelle Treilleux Alain Viari Sophie Léon Mojgan Devouassoux-Shisheboran Nicolas Voirin Christelle de la Fouchardière Brigitte Manship Alain Puisieux Christine Lasset Caroline Moyret-Lalle Integrated analysis highlights APC11 protein expression as a likely new independent predictive marker for colorectal cancer
description	Abstract After a diagnosis of colorectal cancer (CRC), approximately 50% of patients will present distant metastasis. Although significant progress has been made in treatments, most of them will die from the disease. We investigated the predictive and prognostic potential of APC11, the catalytic subunit of APC/C, which has never been examined in the context of CRC. The expression of APC11 was assessed in CRC cell lines, in tissue microarrays (TMAs) and in public datasets. Overexpression of APC11 mRNA was associated with chromosomal instability, lymphovascular invasion and residual tumor. Regression models accounting for the effects of well-known protein markers highlighted association of APC11 protein expression with residual tumor (odds ratio: OR = 6.51; 95% confidence intervals: CI = 1.54–27.59; P = 0.012) and metastasis at diagnosis (OR = 3.87; 95% CI = 1.20–2.45; P = 0.024). Overexpression of APC11 protein was also associated with worse distant relapse-free survival (hazard ratio: HR = 2.60; 95% CI = 1.26–5.37; P = 0.01) and worse overall survival (HR = 2.69; 95% CI = 1.31–5.51; P = 0.007). APC11 overexpression in primary CRC thus represents a potentially novel theranostic marker of metastatic CRC.
format	article
author	Youenn Drouet Isabelle Treilleux Alain Viari Sophie Léon Mojgan Devouassoux-Shisheboran Nicolas Voirin Christelle de la Fouchardière Brigitte Manship Alain Puisieux Christine Lasset Caroline Moyret-Lalle
author_facet	Youenn Drouet Isabelle Treilleux Alain Viari Sophie Léon Mojgan Devouassoux-Shisheboran Nicolas Voirin Christelle de la Fouchardière Brigitte Manship Alain Puisieux Christine Lasset Caroline Moyret-Lalle
author_sort	Youenn Drouet
title	Integrated analysis highlights APC11 protein expression as a likely new independent predictive marker for colorectal cancer
title_short	Integrated analysis highlights APC11 protein expression as a likely new independent predictive marker for colorectal cancer
title_full	Integrated analysis highlights APC11 protein expression as a likely new independent predictive marker for colorectal cancer
title_fullStr	Integrated analysis highlights APC11 protein expression as a likely new independent predictive marker for colorectal cancer
title_full_unstemmed	Integrated analysis highlights APC11 protein expression as a likely new independent predictive marker for colorectal cancer
title_sort	integrated analysis highlights apc11 protein expression as a likely new independent predictive marker for colorectal cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cb2b22da5cf344ad9f5d72362d671496
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Integrated analysis highlights APC11 protein expression as a likely new independent predictive marker for colorectal cancer

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