Antagonistic Pleiotropy in the Bifunctional Surface Protein FadL (OmpP1) during Adaptation of <named-content content-type="genus-species">Haemophilus influenzae</named-content> to Chronic Lung Infection Associated with Chronic Obstructive Pulmonary Disease

Antagonistic Pleiotropy in the Bifunctional Surface Protein FadL (OmpP1) during Adaptation of <named-content content-type="genus-species">Haemophilus influenzae</named-content> to Chronic Lung Infection Associated with Chronic Obstructive Pulmonary Disease

ABSTRACT Tracking bacterial evolution during chronic infection provides insights into how host selection pressures shape bacterial genomes. The human-restricted opportunistic pathogen nontypeable Haemophilus influenzae (NTHi) infects the lower airways of patients suffering chronic obstructive pulmon...

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Main Authors: Javier Moleres, Ariadna Fernández-Calvet, Rachel L. Ehrlich, Sara Martí, Lucía Pérez-Regidor, Begoña Euba, Irene Rodríguez-Arce, Sergey Balashov, Ester Cuevas, Josefina Liñares, Carmen Ardanuy, Sonsoles Martín-Santamaría, Garth D. Ehrlich, Joshua Chang Mell, Junkal Garmendia
Format: article
Language:EN
Published: American Society for Microbiology 2018
Subjects:
CEACAM1
FadL/OmpP1
Haemophilus influenzae
adaptive evolution
antagonistic pleiotropic
chronic obstructive pulmonary disease
Microbiology
QR1-502
Online Access:https://doaj.org/article/cb2d1564d60c4e4f982642d3ba3cf375
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