EXTENDED HILDEBRAND SOLUBILITY APPROACH FOR NAPROXEN SOLUBILITY ESTIMATION IN ETHANOL + WATER COSOLVENT MIXTURES
Naproxen (NAP) is a widely used non-steroidal anti-inflammatory drug; however their physicochemical properties have not been thoroughly studied. In this work, Extended Hildebrand Solubility Approach (EHSA) developed by Martin et al was applied to evaluate the solubility of NAP in ethanol + water cos...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Universidad de Antioquia
2009
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/cb2e45585f024f4ca84321ecdb745add |
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| Sumario: | Naproxen (NAP) is a widely used non-steroidal anti-inflammatory drug; however their physicochemical
properties have not been thoroughly studied. In this work, Extended Hildebrand Solubility Approach
(EHSA) developed by Martin et al was applied to evaluate the solubility of NAP in ethanol + water
cosolvent mixtures at 298.15 K ± 0.05 K. Molar volume and solubility parameter values of NAP, were
calculated according to Fedors and van Krevelen methods. A good predictive capacity of EHSA was found
using regular polynomial models in fifth order for NAP, when the W interaction parameter is related
to the solubility parameter of the cosolvent mixtures. Nevertheless, deviations on estimated solubility
obtained respect to experimental solubility values had shown the same order compared with those
obtained directly by logarithm empirical regression means of experimental solubilities as a function of
cosolvent solubility parameters
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