EXTENDED HILDEBRAND SOLUBILITY APPROACH FOR NAPROXEN SOLUBILITY ESTIMATION IN ETHANOL + WATER COSOLVENT MIXTURES

Naproxen (NAP) is a widely used non-steroidal anti-inflammatory drug; however their physicochemical properties have not been thoroughly studied. In this work, Extended Hildebrand Solubility Approach (EHSA) developed by Martin et al was applied to evaluate the solubility of NAP in ethanol + water cos...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Diana M. ARAGON N., Diana P. PACHECO A., Millar A. RUIDIAZ M., Alejandro D. SOSNIK, Fleming MARTÍNEZ R.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	naproxen solubility estimation Extended Hildebrand Solubility Approach cosolvent mixtures Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/cb2e45585f024f4ca84321ecdb745add
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cb2e45585f024f4ca84321ecdb745add
record_format	dspace
spelling	oai:doaj.org-article:cb2e45585f024f4ca84321ecdb745add2021-11-19T04:18:40ZEXTENDED HILDEBRAND SOLUBILITY APPROACH FOR NAPROXEN SOLUBILITY ESTIMATION IN ETHANOL + WATER COSOLVENT MIXTURES0121-40042145-2660https://doaj.org/article/cb2e45585f024f4ca84321ecdb745add2009-02-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/773https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660Naproxen (NAP) is a widely used non-steroidal anti-inflammatory drug; however their physicochemical properties have not been thoroughly studied. In this work, Extended Hildebrand Solubility Approach (EHSA) developed by Martin et al was applied to evaluate the solubility of NAP in ethanol + water cosolvent mixtures at 298.15 K ± 0.05 K. Molar volume and solubility parameter values of NAP, were calculated according to Fedors and van Krevelen methods. A good predictive capacity of EHSA was found using regular polynomial models in fifth order for NAP, when the W interaction parameter is related to the solubility parameter of the cosolvent mixtures. Nevertheless, deviations on estimated solubility obtained respect to experimental solubility values had shown the same order compared with those obtained directly by logarithm empirical regression means of experimental solubilities as a function of cosolvent solubility parameters Diana M. ARAGON N.Diana P. PACHECO A.Millar A. RUIDIAZ M.Alejandro D. SOSNIKFleming MARTÍNEZ R.Universidad de Antioquiaarticlenaproxensolubility estimationExtended Hildebrand Solubility Approachcosolvent mixturesFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 15, Iss 1 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	naproxen solubility estimation Extended Hildebrand Solubility Approach cosolvent mixtures Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	naproxen solubility estimation Extended Hildebrand Solubility Approach cosolvent mixtures Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Diana M. ARAGON N. Diana P. PACHECO A. Millar A. RUIDIAZ M. Alejandro D. SOSNIK Fleming MARTÍNEZ R. EXTENDED HILDEBRAND SOLUBILITY APPROACH FOR NAPROXEN SOLUBILITY ESTIMATION IN ETHANOL + WATER COSOLVENT MIXTURES
description	Naproxen (NAP) is a widely used non-steroidal anti-inflammatory drug; however their physicochemical properties have not been thoroughly studied. In this work, Extended Hildebrand Solubility Approach (EHSA) developed by Martin et al was applied to evaluate the solubility of NAP in ethanol + water cosolvent mixtures at 298.15 K ± 0.05 K. Molar volume and solubility parameter values of NAP, were calculated according to Fedors and van Krevelen methods. A good predictive capacity of EHSA was found using regular polynomial models in fifth order for NAP, when the W interaction parameter is related to the solubility parameter of the cosolvent mixtures. Nevertheless, deviations on estimated solubility obtained respect to experimental solubility values had shown the same order compared with those obtained directly by logarithm empirical regression means of experimental solubilities as a function of cosolvent solubility parameters
format	article
author	Diana M. ARAGON N. Diana P. PACHECO A. Millar A. RUIDIAZ M. Alejandro D. SOSNIK Fleming MARTÍNEZ R.
author_facet	Diana M. ARAGON N. Diana P. PACHECO A. Millar A. RUIDIAZ M. Alejandro D. SOSNIK Fleming MARTÍNEZ R.
author_sort	Diana M. ARAGON N.
title	EXTENDED HILDEBRAND SOLUBILITY APPROACH FOR NAPROXEN SOLUBILITY ESTIMATION IN ETHANOL + WATER COSOLVENT MIXTURES
title_short	EXTENDED HILDEBRAND SOLUBILITY APPROACH FOR NAPROXEN SOLUBILITY ESTIMATION IN ETHANOL + WATER COSOLVENT MIXTURES
title_full	EXTENDED HILDEBRAND SOLUBILITY APPROACH FOR NAPROXEN SOLUBILITY ESTIMATION IN ETHANOL + WATER COSOLVENT MIXTURES
title_fullStr	EXTENDED HILDEBRAND SOLUBILITY APPROACH FOR NAPROXEN SOLUBILITY ESTIMATION IN ETHANOL + WATER COSOLVENT MIXTURES
title_full_unstemmed	EXTENDED HILDEBRAND SOLUBILITY APPROACH FOR NAPROXEN SOLUBILITY ESTIMATION IN ETHANOL + WATER COSOLVENT MIXTURES
title_sort	extended hildebrand solubility approach for naproxen solubility estimation in ethanol + water cosolvent mixtures
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/cb2e45585f024f4ca84321ecdb745add
work_keys_str_mv	AT dianamaragonn extendedhildebrandsolubilityapproachfornaproxensolubilityestimationinethanolwatercosolventmixtures AT dianappachecoa extendedhildebrandsolubilityapproachfornaproxensolubilityestimationinethanolwatercosolventmixtures AT millararuidiazm extendedhildebrandsolubilityapproachfornaproxensolubilityestimationinethanolwatercosolventmixtures AT alejandrodsosnik extendedhildebrandsolubilityapproachfornaproxensolubilityestimationinethanolwatercosolventmixtures AT flemingmartinezr extendedhildebrandsolubilityapproachfornaproxensolubilityestimationinethanolwatercosolventmixtures
_version_	1718420440780636160

EXTENDED HILDEBRAND SOLUBILITY APPROACH FOR NAPROXEN SOLUBILITY ESTIMATION IN ETHANOL + WATER COSOLVENT MIXTURES

Ejemplares similares