Gut microbiota: next frontier in understanding human health and development of biotherapeutics

Satya Prakash, Laetitia Rodes, Michael Coussa-Charley, Catherine Tomaro-DuchesneauBiomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, Montreal, Quebec, CanadaAbstract...

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Autores principales:	Prakash S, Rodes L, Coussa-Charley M, Tomaro-Duchesneau C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cb2e6987a8c0444dbdbe0c88bd8f5481
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spelling	oai:doaj.org-article:cb2e6987a8c0444dbdbe0c88bd8f54812021-12-02T04:29:22ZGut microbiota: next frontier in understanding human health and development of biotherapeutics1177-54751177-5491https://doaj.org/article/cb2e6987a8c0444dbdbe0c88bd8f54812011-07-01T00:00:00Zhttp://www.dovepress.com/gut-microbiota-next-frontier-in-understanding-human-health-and-develop-a7837https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Satya Prakash, Laetitia Rodes, Michael Coussa-Charley, Catherine Tomaro-DuchesneauBiomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, Montreal, Quebec, CanadaAbstract: The gut microbiota is a remarkable asset for human health. As a key element in the development and prevention of specific diseases, its study has yielded a new field of promising biotherapeutics. This review provides comprehensive and updated knowledge of the human gut microbiota, its implications in health and disease, and the potentials and limitations of its modification by currently available biotherapeutics to treat, prevent and/or restore human health, and future directions. Homeostasis of the gut microbiota maintains various functions which are vital to the maintenance of human health. Disruption of the intestinal ecosystem equilibrium (gut dysbiosis) is associated with a plethora of human diseases, including autoimmune and allergic diseases, colorectal cancer, metabolic diseases, and bacterial infections. Relevant underlying mechanisms by which specific intestinal bacteria populations might trigger the development of disease in susceptible hosts are being explored across the globe. Beneficial modulation of the gut microbiota using biotherapeutics, such as prebiotics, probiotics, and antibiotics, may favor health-promoting populations of bacteria and can be exploited in development of biotherapeutics. Other technologies, such as development of human gut models, bacterial screening, and delivery formulations eg, microencapsulated probiotics, may contribute significantly in the near future. Therefore, the human gut microbiota is a legitimate therapeutic target to treat and/or prevent various diseases. Development of a clear understanding of the technologies needed to exploit the gut microbiota is urgently required.Keywords: gut microbiota, human health, dysbiosis, biotherapeutics, probiotics, microencapsulationPrakash SRodes LCoussa-Charley MTomaro-Duchesneau CDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2011, Iss default, Pp 71-86 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Prakash S Rodes L Coussa-Charley M Tomaro-Duchesneau C Gut microbiota: next frontier in understanding human health and development of biotherapeutics
description	Satya Prakash, Laetitia Rodes, Michael Coussa-Charley, Catherine Tomaro-DuchesneauBiomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, Montreal, Quebec, CanadaAbstract: The gut microbiota is a remarkable asset for human health. As a key element in the development and prevention of specific diseases, its study has yielded a new field of promising biotherapeutics. This review provides comprehensive and updated knowledge of the human gut microbiota, its implications in health and disease, and the potentials and limitations of its modification by currently available biotherapeutics to treat, prevent and/or restore human health, and future directions. Homeostasis of the gut microbiota maintains various functions which are vital to the maintenance of human health. Disruption of the intestinal ecosystem equilibrium (gut dysbiosis) is associated with a plethora of human diseases, including autoimmune and allergic diseases, colorectal cancer, metabolic diseases, and bacterial infections. Relevant underlying mechanisms by which specific intestinal bacteria populations might trigger the development of disease in susceptible hosts are being explored across the globe. Beneficial modulation of the gut microbiota using biotherapeutics, such as prebiotics, probiotics, and antibiotics, may favor health-promoting populations of bacteria and can be exploited in development of biotherapeutics. Other technologies, such as development of human gut models, bacterial screening, and delivery formulations eg, microencapsulated probiotics, may contribute significantly in the near future. Therefore, the human gut microbiota is a legitimate therapeutic target to treat and/or prevent various diseases. Development of a clear understanding of the technologies needed to exploit the gut microbiota is urgently required.Keywords: gut microbiota, human health, dysbiosis, biotherapeutics, probiotics, microencapsulation
format	article
author	Prakash S Rodes L Coussa-Charley M Tomaro-Duchesneau C
author_facet	Prakash S Rodes L Coussa-Charley M Tomaro-Duchesneau C
author_sort	Prakash S
title	Gut microbiota: next frontier in understanding human health and development of biotherapeutics
title_short	Gut microbiota: next frontier in understanding human health and development of biotherapeutics
title_full	Gut microbiota: next frontier in understanding human health and development of biotherapeutics
title_fullStr	Gut microbiota: next frontier in understanding human health and development of biotherapeutics
title_full_unstemmed	Gut microbiota: next frontier in understanding human health and development of biotherapeutics
title_sort	gut microbiota: next frontier in understanding human health and development of biotherapeutics
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/cb2e6987a8c0444dbdbe0c88bd8f5481
work_keys_str_mv	AT prakashs gutmicrobiotanextfrontierinunderstandinghumanhealthanddevelopmentofbiotherapeutics AT rodesl gutmicrobiotanextfrontierinunderstandinghumanhealthanddevelopmentofbiotherapeutics AT coussacharleym gutmicrobiotanextfrontierinunderstandinghumanhealthanddevelopmentofbiotherapeutics AT tomaroduchesneauc gutmicrobiotanextfrontierinunderstandinghumanhealthanddevelopmentofbiotherapeutics
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Gut microbiota: next frontier in understanding human health and development of biotherapeutics

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