Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus

Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus

Abstract Ischemia reperfusion (IR) injury may be attenuated through succinate dehydrogenase (SDH) inhibition by dimethyl malonate (DiMAL). Whether SDH inhibition yields protection in diabetic individuals and translates into human cardiac tissue remain unknown. In isolated perfused hearts from 24 wee...

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Main Authors: Nichlas Riise Jespersen, Marie Vognstoft Hjortbak, Thomas Ravn Lassen, Nicolaj Brejnholt Støttrup, Jacob Johnsen, Pernille Tilma Tonnesen, Steen Larsen, Hans-Henrik Kimose, Hans Erik Bøtker
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/cb3202da68854c63bc7f4b39308a071c
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