Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH): Optimal Management

Giulia Mentrasti,* Laura Scortichini,* Mariangela Torniai, Riccardo Giampieri, Francesca Morgese, Silvia Rinaldi, Rossana Berardi Clinica Oncologica, Università Politecnica delle Marche, AOU Ospedali Riuniti Di Ancona, Ancona, Italy*These authors contributed equally to this workCorrespond...

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Autores principales:	Mentrasti G, Scortichini L, Torniai M, Giampieri R, Morgese F, Rinaldi S, Berardi R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	siadh hyponatremia prognosis neoplasms lung cancer Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/cb35c0a170364cf4865e08b9642d6838
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spelling	oai:doaj.org-article:cb35c0a170364cf4865e08b9642d68382021-12-02T11:05:07ZSyndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH): Optimal Management1178-203Xhttps://doaj.org/article/cb35c0a170364cf4865e08b9642d68382020-07-01T00:00:00Zhttps://www.dovepress.com/syndrome-of-inappropriate-antidiuretic-hormone-secretion-siadh-optimal-peer-reviewed-article-TCRMhttps://doaj.org/toc/1178-203XGiulia Mentrasti,* Laura Scortichini,* Mariangela Torniai, Riccardo Giampieri, Francesca Morgese, Silvia Rinaldi, Rossana Berardi Clinica Oncologica, Università Politecnica delle Marche, AOU Ospedali Riuniti Di Ancona, Ancona, Italy*These authors contributed equally to this workCorrespondence: Rossana BerardiClinica Oncologica, Università Politecnica delle Marche, AOU Ospedali Riuniti Di Ancona, Via Conca 71, Ancona 60126, ItalyTel +39 071 5965715Fax +39 071 5965053Email r.berardi@univpm.itAbstract: Hyponatremia, defined as serum sodium concentration < 135 mEq/l, is the most common electrolyte balance disorder in clinical practice. Many causes are listed, but syndrome of inappropriate antidiuretic hormone secretion (SIADH) is certainly the most relevant, mainly in oncological and hospitalized patients. In this review, the pathophysiological and clinical aspects are described in detail. Patients’ extensive medical history and structured physical and biochemical tests are considered the milestones marking the way of the SIADH management as to provide early detection and proper correction. We focused our attention on the poor prognostic role and negative effect on patient’s quality of life of SIADH-induced hyponatremia in both malignant and non-malignant settings, stressing how optimal management of this electrolyte imbalance can result in improved outcomes and lower health costs.Keywords: SIADH, hyponatremia, prognosis, neoplasms, lung cancerMentrasti GScortichini LTorniai MGiampieri RMorgese FRinaldi SBerardi RDove Medical Pressarticlesiadhhyponatremiaprognosisneoplasmslung cancerTherapeutics. PharmacologyRM1-950ENTherapeutics and Clinical Risk Management, Vol Volume 16, Pp 663-672 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	siadh hyponatremia prognosis neoplasms lung cancer Therapeutics. Pharmacology RM1-950
spellingShingle	siadh hyponatremia prognosis neoplasms lung cancer Therapeutics. Pharmacology RM1-950 Mentrasti G Scortichini L Torniai M Giampieri R Morgese F Rinaldi S Berardi R Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH): Optimal Management
description	Giulia Mentrasti,* Laura Scortichini,* Mariangela Torniai, Riccardo Giampieri, Francesca Morgese, Silvia Rinaldi, Rossana Berardi Clinica Oncologica, Università Politecnica delle Marche, AOU Ospedali Riuniti Di Ancona, Ancona, Italy*These authors contributed equally to this workCorrespondence: Rossana BerardiClinica Oncologica, Università Politecnica delle Marche, AOU Ospedali Riuniti Di Ancona, Via Conca 71, Ancona 60126, ItalyTel +39 071 5965715Fax +39 071 5965053Email r.berardi@univpm.itAbstract: Hyponatremia, defined as serum sodium concentration < 135 mEq/l, is the most common electrolyte balance disorder in clinical practice. Many causes are listed, but syndrome of inappropriate antidiuretic hormone secretion (SIADH) is certainly the most relevant, mainly in oncological and hospitalized patients. In this review, the pathophysiological and clinical aspects are described in detail. Patients’ extensive medical history and structured physical and biochemical tests are considered the milestones marking the way of the SIADH management as to provide early detection and proper correction. We focused our attention on the poor prognostic role and negative effect on patient’s quality of life of SIADH-induced hyponatremia in both malignant and non-malignant settings, stressing how optimal management of this electrolyte imbalance can result in improved outcomes and lower health costs.Keywords: SIADH, hyponatremia, prognosis, neoplasms, lung cancer
format	article
author	Mentrasti G Scortichini L Torniai M Giampieri R Morgese F Rinaldi S Berardi R
author_facet	Mentrasti G Scortichini L Torniai M Giampieri R Morgese F Rinaldi S Berardi R
author_sort	Mentrasti G
title	Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH): Optimal Management
title_short	Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH): Optimal Management
title_full	Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH): Optimal Management
title_fullStr	Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH): Optimal Management
title_full_unstemmed	Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH): Optimal Management
title_sort	syndrome of inappropriate antidiuretic hormone secretion (siadh): optimal management
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/cb35c0a170364cf4865e08b9642d6838
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Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH): Optimal Management

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