Boolean network model for cancer pathways: predicting carcinogenesis and targeted therapy outcomes.
A Boolean dynamical system integrating the main signaling pathways involved in cancer is constructed based on the currently known protein-protein interaction network. This system exhibits stationary protein activation patterns--attractors--dependent on the cell's microenvironment. These dynamic...
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Autores principales: | , |
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Formato: | article |
Lenguaje: | EN |
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Public Library of Science (PLoS)
2013
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Acceso en línea: | https://doaj.org/article/cb38104c583c4bc99e6478986309aad5 |
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