The recovery status from delayed graft function can predict long-term outcome after deceased donor kidney transplantation

Abstract The effect of delayed graft function (DGF) recovery on long-term graft outcome is unclear. The aim of this study was to examine the association of DGF recovery status with long-term outcome. We analyzed 385 recipients who underwent single kidney transplantation from brain-dead donors betwee...

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Autores principales: Juhan Lee, Seung Hwan Song, Jee Youn Lee, Deok Gie Kim, Jae Geun Lee, Beom Seok Kim, Myoung Soo Kim, Kyu Ha Huh
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Publicado: Nature Portfolio 2017
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spelling oai:doaj.org-article:cb3cd04141f942829dfd0eae4ea01dae2021-12-02T15:05:42ZThe recovery status from delayed graft function can predict long-term outcome after deceased donor kidney transplantation10.1038/s41598-017-14154-w2045-2322https://doaj.org/article/cb3cd04141f942829dfd0eae4ea01dae2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-14154-whttps://doaj.org/toc/2045-2322Abstract The effect of delayed graft function (DGF) recovery on long-term graft outcome is unclear. The aim of this study was to examine the association of DGF recovery status with long-term outcome. We analyzed 385 recipients who underwent single kidney transplantation from brain-dead donors between 2004 and 2015. Patients were grouped according to renal function at 1 month post-transplantation: control (without DGF); recovered DGF (glomerular filtration rate [GFR] ≥ 30 mL/min/1.73 m2); and incompletely recovered DGF group (GFR < 30 mL/min/1.73 m2). DGF occurred in 104 of 385 (27%) recipients. Of the DGF patients, 70 recovered from DGF and 34 incompletely recovered from DGF. Death-censored graft survival rates for control, recovered DGF, and incompletely recovered DGF groups were 95.3%, 94.7%, and 80.7%, respectively, at 5 years post-transplantation (P = 0.003). Incompletely recovered DGF was an independent risk factor for death-censored graft loss (HR = 3.410, 95%CI, 1.114-10.437). DGF was associated with increased risk for patient death regardless of DGF recovery status. Mean GFRs at 5 years were 65.5 ± 20.8, 62.2 ± 27.0, and 45.8 ± 15.4 mL/min/1.73 m2 for control, recovered, and incompletely recovered DGF groups, respectively (P < 0.001). Control group and recovered DGF patients had similar renal outcomes. However, DGF was associated with increased risk for patient death regardless of DGF recovery status.Juhan LeeSeung Hwan SongJee Youn LeeDeok Gie KimJae Geun LeeBeom Seok KimMyoung Soo KimKyu Ha HuhNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Juhan Lee
Seung Hwan Song
Jee Youn Lee
Deok Gie Kim
Jae Geun Lee
Beom Seok Kim
Myoung Soo Kim
Kyu Ha Huh
The recovery status from delayed graft function can predict long-term outcome after deceased donor kidney transplantation
description Abstract The effect of delayed graft function (DGF) recovery on long-term graft outcome is unclear. The aim of this study was to examine the association of DGF recovery status with long-term outcome. We analyzed 385 recipients who underwent single kidney transplantation from brain-dead donors between 2004 and 2015. Patients were grouped according to renal function at 1 month post-transplantation: control (without DGF); recovered DGF (glomerular filtration rate [GFR] ≥ 30 mL/min/1.73 m2); and incompletely recovered DGF group (GFR < 30 mL/min/1.73 m2). DGF occurred in 104 of 385 (27%) recipients. Of the DGF patients, 70 recovered from DGF and 34 incompletely recovered from DGF. Death-censored graft survival rates for control, recovered DGF, and incompletely recovered DGF groups were 95.3%, 94.7%, and 80.7%, respectively, at 5 years post-transplantation (P = 0.003). Incompletely recovered DGF was an independent risk factor for death-censored graft loss (HR = 3.410, 95%CI, 1.114-10.437). DGF was associated with increased risk for patient death regardless of DGF recovery status. Mean GFRs at 5 years were 65.5 ± 20.8, 62.2 ± 27.0, and 45.8 ± 15.4 mL/min/1.73 m2 for control, recovered, and incompletely recovered DGF groups, respectively (P < 0.001). Control group and recovered DGF patients had similar renal outcomes. However, DGF was associated with increased risk for patient death regardless of DGF recovery status.
format article
author Juhan Lee
Seung Hwan Song
Jee Youn Lee
Deok Gie Kim
Jae Geun Lee
Beom Seok Kim
Myoung Soo Kim
Kyu Ha Huh
author_facet Juhan Lee
Seung Hwan Song
Jee Youn Lee
Deok Gie Kim
Jae Geun Lee
Beom Seok Kim
Myoung Soo Kim
Kyu Ha Huh
author_sort Juhan Lee
title The recovery status from delayed graft function can predict long-term outcome after deceased donor kidney transplantation
title_short The recovery status from delayed graft function can predict long-term outcome after deceased donor kidney transplantation
title_full The recovery status from delayed graft function can predict long-term outcome after deceased donor kidney transplantation
title_fullStr The recovery status from delayed graft function can predict long-term outcome after deceased donor kidney transplantation
title_full_unstemmed The recovery status from delayed graft function can predict long-term outcome after deceased donor kidney transplantation
title_sort recovery status from delayed graft function can predict long-term outcome after deceased donor kidney transplantation
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/cb3cd04141f942829dfd0eae4ea01dae
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