Clofilium inhibits Slick and Slack potassium channels

Maria de los Angeles Tejada,1 Kathleen Stolpe,1 Anne-Kristine Meinild,2 Dan A Klaerke11Department of Physiology and Biochemistry, Faculty of Life Sciences, 2Institute of Biology, Faculty of Science, University of Copenhagen, Copenhagen, DenmarkAbstract: Slick and Slack high-conductance potassium cha...

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Autores principales:	Tejada MA, Stolpe K, Meinild AK, Klaerke DA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cb3eaff9a78d4b9caa893057de1af674
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spelling	oai:doaj.org-article:cb3eaff9a78d4b9caa893057de1af6742021-12-02T00:25:57ZClofilium inhibits Slick and Slack potassium channels1177-54751177-5491https://doaj.org/article/cb3eaff9a78d4b9caa893057de1af6742012-12-01T00:00:00Zhttp://www.dovepress.com/clofilium-inhibits-slick-and-slack-potassium-channels-a11748https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Maria de los Angeles Tejada,1 Kathleen Stolpe,1 Anne-Kristine Meinild,2 Dan A Klaerke11Department of Physiology and Biochemistry, Faculty of Life Sciences, 2Institute of Biology, Faculty of Science, University of Copenhagen, Copenhagen, DenmarkAbstract: Slick and Slack high-conductance potassium channels have been recently discovered, and are found in the central nervous system and in the heart. Both channels are activated by Na+ and Cl-, and Slick channels are also inhibited by adenosine triphospate (ATP). An important role of setting the resting membrane potential and controlling the basal excitability of neurons has been suggested for these channels. In addition, no specific blockers for these channels are known up to the present. With the purpose of studying the pharmacological characteristics of Slick and Slack channels, the effects of exposure to the antiarrhythmic compound clofilium were evaluated. Clofilium was able to modulate the activity of Slick and Slack channels effectively, with a stronger effect on Slack than Slick channels. In order to evaluate the pharmacological behavior of Slick and Slack channels further, 38 commonly used potassium channel blockers were tested. Screening of these compounds did not reveal any modulators of Slick and Slack channels, except for clofilium. The present study provides a first approach towards elucidating the pharmacological characteristics of Slick and Slack channels and could be the basis for future studies aimed at developing potent and specific blockers and activators for these channels.Keywords: Slo2.1, Slo2.2, clofilium, potassium channel blockersTejada MAStolpe KMeinild AKKlaerke DADove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2012, Iss default, Pp 465-470 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Tejada MA Stolpe K Meinild AK Klaerke DA Clofilium inhibits Slick and Slack potassium channels
description	Maria de los Angeles Tejada,1 Kathleen Stolpe,1 Anne-Kristine Meinild,2 Dan A Klaerke11Department of Physiology and Biochemistry, Faculty of Life Sciences, 2Institute of Biology, Faculty of Science, University of Copenhagen, Copenhagen, DenmarkAbstract: Slick and Slack high-conductance potassium channels have been recently discovered, and are found in the central nervous system and in the heart. Both channels are activated by Na+ and Cl-, and Slick channels are also inhibited by adenosine triphospate (ATP). An important role of setting the resting membrane potential and controlling the basal excitability of neurons has been suggested for these channels. In addition, no specific blockers for these channels are known up to the present. With the purpose of studying the pharmacological characteristics of Slick and Slack channels, the effects of exposure to the antiarrhythmic compound clofilium were evaluated. Clofilium was able to modulate the activity of Slick and Slack channels effectively, with a stronger effect on Slack than Slick channels. In order to evaluate the pharmacological behavior of Slick and Slack channels further, 38 commonly used potassium channel blockers were tested. Screening of these compounds did not reveal any modulators of Slick and Slack channels, except for clofilium. The present study provides a first approach towards elucidating the pharmacological characteristics of Slick and Slack channels and could be the basis for future studies aimed at developing potent and specific blockers and activators for these channels.Keywords: Slo2.1, Slo2.2, clofilium, potassium channel blockers
format	article
author	Tejada MA Stolpe K Meinild AK Klaerke DA
author_facet	Tejada MA Stolpe K Meinild AK Klaerke DA
author_sort	Tejada MA
title	Clofilium inhibits Slick and Slack potassium channels
title_short	Clofilium inhibits Slick and Slack potassium channels
title_full	Clofilium inhibits Slick and Slack potassium channels
title_fullStr	Clofilium inhibits Slick and Slack potassium channels
title_full_unstemmed	Clofilium inhibits Slick and Slack potassium channels
title_sort	clofilium inhibits slick and slack potassium channels
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/cb3eaff9a78d4b9caa893057de1af674
work_keys_str_mv	AT tejadama clofiliuminhibitsslickandslackpotassiumchannels AT stolpek clofiliuminhibitsslickandslackpotassiumchannels AT meinildak clofiliuminhibitsslickandslackpotassiumchannels AT klaerkeda clofiliuminhibitsslickandslackpotassiumchannels
_version_	1718403767240491008

Clofilium inhibits Slick and Slack potassium channels

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