Evaluating intraocular pressure-lowering solutions for the treatment of open-angle glaucoma: comparison between bimatoprost 0.03% and bimatoprost 0.01% – an observational switch study
Sarita S Deshpande,1 Sriram Sonty,1,2 Afzal Ahmad1 1Glaucoma Section, Midwest Eye Center, Calumet City, 2Glaucoma Section, Department of Ophthalmology, University of Illinois at Chicago, Chicago, IL, USA Purpose: The purpose of this study is to evaluate the intraocular pressure (IOP)-lowering effi...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/cb4147d332704aee8185faf227b4930b |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:cb4147d332704aee8185faf227b4930b |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:cb4147d332704aee8185faf227b4930b2021-12-02T02:13:26ZEvaluating intraocular pressure-lowering solutions for the treatment of open-angle glaucoma: comparison between bimatoprost 0.03% and bimatoprost 0.01% – an observational switch study1177-5483https://doaj.org/article/cb4147d332704aee8185faf227b4930b2017-07-01T00:00:00Zhttps://www.dovepress.com/evaluating-intraocular-pressure-lowering-solutions-for-the-treatment-o-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Sarita S Deshpande,1 Sriram Sonty,1,2 Afzal Ahmad1 1Glaucoma Section, Midwest Eye Center, Calumet City, 2Glaucoma Section, Department of Ophthalmology, University of Illinois at Chicago, Chicago, IL, USA Purpose: The purpose of this study is to evaluate the intraocular pressure (IOP)-lowering efficacy of bimatoprost 0.01% solution in patients with primary open-angle glaucoma (POAG), who were switched from bimatoprost 0.03% solution, compared to patients with POAG who continued on bimatoprost 0.03% solution.Methods: A retrospective review evaluated 35 patients (35 right eyes [OD], 34 left eyes [OS]) who remained on bimatoprost 0.03% and 30 patients (27 OD, 30 OS) who were switched to bimatoprost 0.01% during the period January 8, 2010 to December 26, 2012. Mean IOP was measured 6 and 3 months before the switch, at switch, and 3, 6, and 12 months after the switch. Hyperemia scores were recorded before and after the switch and were compared to a picture scale.Results: Mean IOP in the group that switched was 16.96±5.03 mmHg in OD and 17.67±5.33 mmHg in OS at baseline. Mean IOP postswitch to bimatoprost 0.01% solution was 17.60±4.34 mmHg in OD and 17.00±3.37 mmHg in OS. IOP was not significantly reduced in either OD or OS postswitch to bimatoprost 0.01% (P1=0.5 OD, P2=0.2 OS). The hyperemia scores improved remarkably when bimatoprost 0.03% solution was switched to bimatoprost 0.01% solution (P<0.001).Conclusion: To our knowledge, this is the first switch study evaluating the hypotensive efficacy and tolerability of bimatoprost in a group of patients with open-angle glaucoma. In this study comparing bimatoprost 0.03% and 0.01% solution, we found improved tolerability postswitch to 0.01% from 0.03% bimatoprost, similar efficacy between the two concentrations before and after switch in the same patient population, and similar IOPs comparable to nonswitch bimatoprost 0.03% solution. Keywords: bimatoprost, open-angle glaucoma, hyperemia, intraocular pressureDeshpande SSSonty SAhmad ADove Medical Pressarticlebimatoprostopen-angle glaucomahyperemiaOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 1371-1376 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
bimatoprost open-angle glaucoma hyperemia Ophthalmology RE1-994 |
| spellingShingle |
bimatoprost open-angle glaucoma hyperemia Ophthalmology RE1-994 Deshpande SS Sonty S Ahmad A Evaluating intraocular pressure-lowering solutions for the treatment of open-angle glaucoma: comparison between bimatoprost 0.03% and bimatoprost 0.01% – an observational switch study |
| description |
Sarita S Deshpande,1 Sriram Sonty,1,2 Afzal Ahmad1 1Glaucoma Section, Midwest Eye Center, Calumet City, 2Glaucoma Section, Department of Ophthalmology, University of Illinois at Chicago, Chicago, IL, USA Purpose: The purpose of this study is to evaluate the intraocular pressure (IOP)-lowering efficacy of bimatoprost 0.01% solution in patients with primary open-angle glaucoma (POAG), who were switched from bimatoprost 0.03% solution, compared to patients with POAG who continued on bimatoprost 0.03% solution.Methods: A retrospective review evaluated 35 patients (35 right eyes [OD], 34 left eyes [OS]) who remained on bimatoprost 0.03% and 30 patients (27 OD, 30 OS) who were switched to bimatoprost 0.01% during the period January 8, 2010 to December 26, 2012. Mean IOP was measured 6 and 3 months before the switch, at switch, and 3, 6, and 12 months after the switch. Hyperemia scores were recorded before and after the switch and were compared to a picture scale.Results: Mean IOP in the group that switched was 16.96±5.03 mmHg in OD and 17.67±5.33 mmHg in OS at baseline. Mean IOP postswitch to bimatoprost 0.01% solution was 17.60±4.34 mmHg in OD and 17.00±3.37 mmHg in OS. IOP was not significantly reduced in either OD or OS postswitch to bimatoprost 0.01% (P1=0.5 OD, P2=0.2 OS). The hyperemia scores improved remarkably when bimatoprost 0.03% solution was switched to bimatoprost 0.01% solution (P<0.001).Conclusion: To our knowledge, this is the first switch study evaluating the hypotensive efficacy and tolerability of bimatoprost in a group of patients with open-angle glaucoma. In this study comparing bimatoprost 0.03% and 0.01% solution, we found improved tolerability postswitch to 0.01% from 0.03% bimatoprost, similar efficacy between the two concentrations before and after switch in the same patient population, and similar IOPs comparable to nonswitch bimatoprost 0.03% solution. Keywords: bimatoprost, open-angle glaucoma, hyperemia, intraocular pressure |
| format |
article |
| author |
Deshpande SS Sonty S Ahmad A |
| author_facet |
Deshpande SS Sonty S Ahmad A |
| author_sort |
Deshpande SS |
| title |
Evaluating intraocular pressure-lowering solutions for the treatment of open-angle glaucoma: comparison between bimatoprost 0.03% and bimatoprost 0.01% – an observational switch study |
| title_short |
Evaluating intraocular pressure-lowering solutions for the treatment of open-angle glaucoma: comparison between bimatoprost 0.03% and bimatoprost 0.01% – an observational switch study |
| title_full |
Evaluating intraocular pressure-lowering solutions for the treatment of open-angle glaucoma: comparison between bimatoprost 0.03% and bimatoprost 0.01% – an observational switch study |
| title_fullStr |
Evaluating intraocular pressure-lowering solutions for the treatment of open-angle glaucoma: comparison between bimatoprost 0.03% and bimatoprost 0.01% – an observational switch study |
| title_full_unstemmed |
Evaluating intraocular pressure-lowering solutions for the treatment of open-angle glaucoma: comparison between bimatoprost 0.03% and bimatoprost 0.01% – an observational switch study |
| title_sort |
evaluating intraocular pressure-lowering solutions for the treatment of open-angle glaucoma: comparison between bimatoprost 0.03% and bimatoprost 0.01% – an observational switch study |
| publisher |
Dove Medical Press |
| publishDate |
2017 |
| url |
https://doaj.org/article/cb4147d332704aee8185faf227b4930b |
| work_keys_str_mv |
AT deshpandess evaluatingintraocularpressureloweringsolutionsforthetreatmentofopenangleglaucomacomparisonbetweenbimatoprost003andbimatoprost001ndashanobservationalswitchstudy AT sontys evaluatingintraocularpressureloweringsolutionsforthetreatmentofopenangleglaucomacomparisonbetweenbimatoprost003andbimatoprost001ndashanobservationalswitchstudy AT ahmada evaluatingintraocularpressureloweringsolutionsforthetreatmentofopenangleglaucomacomparisonbetweenbimatoprost003andbimatoprost001ndashanobservationalswitchstudy |
| _version_ |
1718402620235710464 |