Neonatal brain injury and neuroanatomy of memory processing following very preterm birth in adulthood: an fMRI study.

Altered functional neuroanatomy of high-order cognitive processing has been described in very preterm individuals (born before 33 weeks of gestation; VPT) compared to controls in childhood and adolescence. However, VPT birth may be accompanied by different types of adverse neonatal events and associ...

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Autores principales:	Anastasia K Kalpakidou, Matthew P Allin, Muriel Walshe, Vincent Giampietro, Kie-woo Nam, Philip McGuire, Larry Rifkin, Robin M Murray, Chiara Nosarti
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cb42915ea0d746a69d154010967fd901
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spelling	oai:doaj.org-article:cb42915ea0d746a69d154010967fd9012021-11-18T07:21:33ZNeonatal brain injury and neuroanatomy of memory processing following very preterm birth in adulthood: an fMRI study.1932-620310.1371/journal.pone.0034858https://doaj.org/article/cb42915ea0d746a69d154010967fd9012012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22532832/?tool=EBIhttps://doaj.org/toc/1932-6203Altered functional neuroanatomy of high-order cognitive processing has been described in very preterm individuals (born before 33 weeks of gestation; VPT) compared to controls in childhood and adolescence. However, VPT birth may be accompanied by different types of adverse neonatal events and associated brain injury, the severity of which may have differential effects on brain development and subsequent neurodevelopmental outcome. We conducted a functional magnetic resonance imaging (fMRI) study to investigate how differing degrees of neonatal brain injury, detected by neonatal ultrasounds, affect the functional neuroanatomy of memory processing in VPT young adults. We used a verbal paired associates learning task, consisting of four encoding, four cued-recall and four baseline condition blocks. To further investigate whether differences in neural activation between the groups were modulated by structural brain changes, structural MRI data were also collected. We studied 12 VPT young adults with a history of periventricular haemorrhage with associated ventricular dilatation, 17 VPT individuals with a history of uncomplicated periventricular haemorrhage, 12 individuals with normal ultrasonographic findings, and 17 controls. Results of a linear trend analysis demonstrated that during completion of the paired associates learning task right frontal and right parietal brain activation decreased as the severity of neonatal brain injury increased. There were no statistically significant between-group differences in on-line task performance and participants' intelligence quotient (IQ) at assessment. This pattern of differential activation across the groups was observed particularly in the right middle frontal gyrus during encoding and in the right posterior cingulate gyrus during recall. Structural MRI data analysis revealed that grey matter volume in the right superior temporal gyrus, right cerebellum, left middle temporal gyrus, right globus pallidus and right medial frontal gyrus decreased with increasing severity of neonatal brain injury. However, the significant between-group functional neuroanatomical differences were not directly attributable to the detected structural regional differences.Anastasia K KalpakidouMatthew P AllinMuriel WalsheVincent GiampietroKie-woo NamPhilip McGuireLarry RifkinRobin M MurrayChiara NosartiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e34858 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anastasia K Kalpakidou Matthew P Allin Muriel Walshe Vincent Giampietro Kie-woo Nam Philip McGuire Larry Rifkin Robin M Murray Chiara Nosarti Neonatal brain injury and neuroanatomy of memory processing following very preterm birth in adulthood: an fMRI study.
description	Altered functional neuroanatomy of high-order cognitive processing has been described in very preterm individuals (born before 33 weeks of gestation; VPT) compared to controls in childhood and adolescence. However, VPT birth may be accompanied by different types of adverse neonatal events and associated brain injury, the severity of which may have differential effects on brain development and subsequent neurodevelopmental outcome. We conducted a functional magnetic resonance imaging (fMRI) study to investigate how differing degrees of neonatal brain injury, detected by neonatal ultrasounds, affect the functional neuroanatomy of memory processing in VPT young adults. We used a verbal paired associates learning task, consisting of four encoding, four cued-recall and four baseline condition blocks. To further investigate whether differences in neural activation between the groups were modulated by structural brain changes, structural MRI data were also collected. We studied 12 VPT young adults with a history of periventricular haemorrhage with associated ventricular dilatation, 17 VPT individuals with a history of uncomplicated periventricular haemorrhage, 12 individuals with normal ultrasonographic findings, and 17 controls. Results of a linear trend analysis demonstrated that during completion of the paired associates learning task right frontal and right parietal brain activation decreased as the severity of neonatal brain injury increased. There were no statistically significant between-group differences in on-line task performance and participants' intelligence quotient (IQ) at assessment. This pattern of differential activation across the groups was observed particularly in the right middle frontal gyrus during encoding and in the right posterior cingulate gyrus during recall. Structural MRI data analysis revealed that grey matter volume in the right superior temporal gyrus, right cerebellum, left middle temporal gyrus, right globus pallidus and right medial frontal gyrus decreased with increasing severity of neonatal brain injury. However, the significant between-group functional neuroanatomical differences were not directly attributable to the detected structural regional differences.
format	article
author	Anastasia K Kalpakidou Matthew P Allin Muriel Walshe Vincent Giampietro Kie-woo Nam Philip McGuire Larry Rifkin Robin M Murray Chiara Nosarti
author_facet	Anastasia K Kalpakidou Matthew P Allin Muriel Walshe Vincent Giampietro Kie-woo Nam Philip McGuire Larry Rifkin Robin M Murray Chiara Nosarti
author_sort	Anastasia K Kalpakidou
title	Neonatal brain injury and neuroanatomy of memory processing following very preterm birth in adulthood: an fMRI study.
title_short	Neonatal brain injury and neuroanatomy of memory processing following very preterm birth in adulthood: an fMRI study.
title_full	Neonatal brain injury and neuroanatomy of memory processing following very preterm birth in adulthood: an fMRI study.
title_fullStr	Neonatal brain injury and neuroanatomy of memory processing following very preterm birth in adulthood: an fMRI study.
title_full_unstemmed	Neonatal brain injury and neuroanatomy of memory processing following very preterm birth in adulthood: an fMRI study.
title_sort	neonatal brain injury and neuroanatomy of memory processing following very preterm birth in adulthood: an fmri study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/cb42915ea0d746a69d154010967fd901
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Neonatal brain injury and neuroanatomy of memory processing following very preterm birth in adulthood: an fMRI study.

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