A Review on Toxicity and Challenges in Transferability of Surface-functionalized Metallic Nanoparticles from Animal Models to Humans

The unique size and surface morphology of nanoparticles (NPs) have substantially influenced all aspects of human life, making nanotechnology a novel and promising field for various applications in biomedical sciences. Metallic NPs have gained immense interest over the last few decades due to their p...

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Autores principales:	Muhammad Arif Asghar, Rabia Ismail Yousuf, Muhammad Harris Shoaib, Muhammad Asif Asghar, Nazish Mumtaz
Formato:	article
Lenguaje:	EN
Publicado:	Compuscript Ltd 2021
Materias:	biomedical applications comparative toxicity human clinical trials metallic nanoparticles nanotechnology surface functionalization Medicine R
Acceso en línea:	https://doaj.org/article/cb42e3c3db3145f79faaf935dfeb1a7a
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spelling	oai:doaj.org-article:cb42e3c3db3145f79faaf935dfeb1a7a2021-11-09T08:30:25ZA Review on Toxicity and Challenges in Transferability of Surface-functionalized Metallic Nanoparticles from Animal Models to Humans2712-008210.15212/bioi-2020-0047https://doaj.org/article/cb42e3c3db3145f79faaf935dfeb1a7a2021-07-01T00:00:00Zhttps://www.ingentaconnect.com/contentone/cscript/bioi/2021/00000002/00000002/art00006https://doaj.org/toc/2712-0082The unique size and surface morphology of nanoparticles (NPs) have substantially influenced all aspects of human life, making nanotechnology a novel and promising field for various applications in biomedical sciences. Metallic NPs have gained immense interest over the last few decades due to their promising optical, electrical, and biological properties. However, the aggregation and the toxic nature of these NPs have restricted their utilization in more optimized applications. The optimum selection of biopolymers and biological macromolecules for surface functionalization of metallic NPs will significantly improve their biological applicability and biocompatibility. The present mini-review attempts to stress the overview of recent strategies involved in surface functionalization of metallic NPs, their specific biomedical applications, and comparison of their in vitro, ex vivo, and in vivo toxicities with non-functionalized metallic NPs. In addition, this review also discusses the various challenges for metallic NPs to undergo human clinical trials.Muhammad Arif AsgharRabia Ismail YousufMuhammad Harris ShoaibMuhammad Asif AsgharNazish MumtazCompuscript Ltdarticlebiomedical applicationscomparative toxicityhuman clinical trialsmetallic nanoparticlesnanotechnologysurface functionalizationMedicineRENBIO Integration, Vol 2, Iss 2, Pp 71-80 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomedical applications comparative toxicity human clinical trials metallic nanoparticles nanotechnology surface functionalization Medicine R
spellingShingle	biomedical applications comparative toxicity human clinical trials metallic nanoparticles nanotechnology surface functionalization Medicine R Muhammad Arif Asghar Rabia Ismail Yousuf Muhammad Harris Shoaib Muhammad Asif Asghar Nazish Mumtaz A Review on Toxicity and Challenges in Transferability of Surface-functionalized Metallic Nanoparticles from Animal Models to Humans
description	The unique size and surface morphology of nanoparticles (NPs) have substantially influenced all aspects of human life, making nanotechnology a novel and promising field for various applications in biomedical sciences. Metallic NPs have gained immense interest over the last few decades due to their promising optical, electrical, and biological properties. However, the aggregation and the toxic nature of these NPs have restricted their utilization in more optimized applications. The optimum selection of biopolymers and biological macromolecules for surface functionalization of metallic NPs will significantly improve their biological applicability and biocompatibility. The present mini-review attempts to stress the overview of recent strategies involved in surface functionalization of metallic NPs, their specific biomedical applications, and comparison of their in vitro, ex vivo, and in vivo toxicities with non-functionalized metallic NPs. In addition, this review also discusses the various challenges for metallic NPs to undergo human clinical trials.
format	article
author	Muhammad Arif Asghar Rabia Ismail Yousuf Muhammad Harris Shoaib Muhammad Asif Asghar Nazish Mumtaz
author_facet	Muhammad Arif Asghar Rabia Ismail Yousuf Muhammad Harris Shoaib Muhammad Asif Asghar Nazish Mumtaz
author_sort	Muhammad Arif Asghar
title	A Review on Toxicity and Challenges in Transferability of Surface-functionalized Metallic Nanoparticles from Animal Models to Humans
title_short	A Review on Toxicity and Challenges in Transferability of Surface-functionalized Metallic Nanoparticles from Animal Models to Humans
title_full	A Review on Toxicity and Challenges in Transferability of Surface-functionalized Metallic Nanoparticles from Animal Models to Humans
title_fullStr	A Review on Toxicity and Challenges in Transferability of Surface-functionalized Metallic Nanoparticles from Animal Models to Humans
title_full_unstemmed	A Review on Toxicity and Challenges in Transferability of Surface-functionalized Metallic Nanoparticles from Animal Models to Humans
title_sort	review on toxicity and challenges in transferability of surface-functionalized metallic nanoparticles from animal models to humans
publisher	Compuscript Ltd
publishDate	2021
url	https://doaj.org/article/cb42e3c3db3145f79faaf935dfeb1a7a
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A Review on Toxicity and Challenges in Transferability of Surface-functionalized Metallic Nanoparticles from Animal Models to Humans

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