Liver‐type fatty acid‐binding protein and neutrophil gelatinase‐associated lipocalin in cats with chronic kidney disease and hyperthyroidism

Abstract Background Liver‐type fatty acid‐binding protein (L‐FABP) and neutrophil gelatinase‐associated lipocalin (NGAL) are candidate biomarkers for the detection of early chronic kidney disease (CKD) in cats. Objective To evaluate urinary and serum L‐FABP and NGAL concentrations in CKD cats and in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Thirawut Kongtasai, Evelyne Meyer, Dominique Paepe, Sofie Marynissen, Pascale Smets, Femke Mortier, Kristel Demeyere, Eva Vandermeulen, Emmelie Stock, Eva Buresova, Pieter Defauw, Luc Duchateau, Sylvie Daminet
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	biomarkers cats CKD hyperthyroid L‐FABP NGAL Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/cb45d94e232b4162b587c0e9dff4fcb1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cb45d94e232b4162b587c0e9dff4fcb1
record_format	dspace
spelling	oai:doaj.org-article:cb45d94e232b4162b587c0e9dff4fcb12021-11-30T17:01:03ZLiver‐type fatty acid‐binding protein and neutrophil gelatinase‐associated lipocalin in cats with chronic kidney disease and hyperthyroidism1939-16760891-664010.1111/jvim.16074https://doaj.org/article/cb45d94e232b4162b587c0e9dff4fcb12021-05-01T00:00:00Zhttps://doi.org/10.1111/jvim.16074https://doaj.org/toc/0891-6640https://doaj.org/toc/1939-1676Abstract Background Liver‐type fatty acid‐binding protein (L‐FABP) and neutrophil gelatinase‐associated lipocalin (NGAL) are candidate biomarkers for the detection of early chronic kidney disease (CKD) in cats. Objective To evaluate urinary and serum L‐FABP and NGAL concentrations in CKD cats and in hyperthyroid cats before and after radioiodine (131I) treatment. Animals Nine CKD cats, 45 healthy cats and hyperthyroid cats at 3 time points including before (T0, n = 49), 1 month (T1, n = 49), and 11 to 29 months after (T2, n = 26) 131I treatment. Methods Cross‐sectional and longitudinal study. Serum L‐FABP (sL‐FABP), serum NGAL (sNGAL), urinary L‐FABP (uL‐FABP), and urinary NGAL (uNGAL) were compared between the 3 groups and between hyperthyroid cats before and after treatment. Data are reported as median (min‐max). Results CKD cats had significantly higher sL‐FABP (13.50 [3.40‐75.60] ng/ml) and uL‐FABP/Cr (4.90 [0.97‐2139.44] µg/g) than healthy cats (4.25 [1.34‐23.25] ng/ml; P = .01 and 0.46 [0.18‐9.13] µg/g; P < .001, respectively). Hyperthyroid cats at T0 had significantly higher uL‐FABP/Cr (0.94 [0.15‐896.00] µg/g) than healthy cats (P < .001), thereafter uL‐FABP/Cr significantly decreased at T2 (0.54 [0.10‐76.41] µg/g, P = .002). For the detection of CKD, uL‐FABP/Cr had 100% (95% confidence interval [CI], 66.4‐100.0) sensitivity and 93.2% (95% CI, 81.3‐98.6) specificity. There were no significant differences in sNGAL and uNGAL/Cr between the 3 groups. Conclusions and Clinical Importance L‐FABP, but not NGAL, is a potential biomarker for the detection of early CKD in cats. Utility of uL‐FABP to predict azotemia after treatment in hyperthyroid cats remains unknown.Thirawut KongtasaiEvelyne MeyerDominique PaepeSofie MarynissenPascale SmetsFemke MortierKristel DemeyereEva VandermeulenEmmelie StockEva BuresovaPieter DefauwLuc DuchateauSylvie DaminetWileyarticlebiomarkerscatsCKDhyperthyroidL‐FABPNGALVeterinary medicineSF600-1100ENJournal of Veterinary Internal Medicine, Vol 35, Iss 3, Pp 1376-1388 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomarkers cats CKD hyperthyroid L‐FABP NGAL Veterinary medicine SF600-1100
spellingShingle	biomarkers cats CKD hyperthyroid L‐FABP NGAL Veterinary medicine SF600-1100 Thirawut Kongtasai Evelyne Meyer Dominique Paepe Sofie Marynissen Pascale Smets Femke Mortier Kristel Demeyere Eva Vandermeulen Emmelie Stock Eva Buresova Pieter Defauw Luc Duchateau Sylvie Daminet Liver‐type fatty acid‐binding protein and neutrophil gelatinase‐associated lipocalin in cats with chronic kidney disease and hyperthyroidism
description	Abstract Background Liver‐type fatty acid‐binding protein (L‐FABP) and neutrophil gelatinase‐associated lipocalin (NGAL) are candidate biomarkers for the detection of early chronic kidney disease (CKD) in cats. Objective To evaluate urinary and serum L‐FABP and NGAL concentrations in CKD cats and in hyperthyroid cats before and after radioiodine (131I) treatment. Animals Nine CKD cats, 45 healthy cats and hyperthyroid cats at 3 time points including before (T0, n = 49), 1 month (T1, n = 49), and 11 to 29 months after (T2, n = 26) 131I treatment. Methods Cross‐sectional and longitudinal study. Serum L‐FABP (sL‐FABP), serum NGAL (sNGAL), urinary L‐FABP (uL‐FABP), and urinary NGAL (uNGAL) were compared between the 3 groups and between hyperthyroid cats before and after treatment. Data are reported as median (min‐max). Results CKD cats had significantly higher sL‐FABP (13.50 [3.40‐75.60] ng/ml) and uL‐FABP/Cr (4.90 [0.97‐2139.44] µg/g) than healthy cats (4.25 [1.34‐23.25] ng/ml; P = .01 and 0.46 [0.18‐9.13] µg/g; P < .001, respectively). Hyperthyroid cats at T0 had significantly higher uL‐FABP/Cr (0.94 [0.15‐896.00] µg/g) than healthy cats (P < .001), thereafter uL‐FABP/Cr significantly decreased at T2 (0.54 [0.10‐76.41] µg/g, P = .002). For the detection of CKD, uL‐FABP/Cr had 100% (95% confidence interval [CI], 66.4‐100.0) sensitivity and 93.2% (95% CI, 81.3‐98.6) specificity. There were no significant differences in sNGAL and uNGAL/Cr between the 3 groups. Conclusions and Clinical Importance L‐FABP, but not NGAL, is a potential biomarker for the detection of early CKD in cats. Utility of uL‐FABP to predict azotemia after treatment in hyperthyroid cats remains unknown.
format	article
author	Thirawut Kongtasai Evelyne Meyer Dominique Paepe Sofie Marynissen Pascale Smets Femke Mortier Kristel Demeyere Eva Vandermeulen Emmelie Stock Eva Buresova Pieter Defauw Luc Duchateau Sylvie Daminet
author_facet	Thirawut Kongtasai Evelyne Meyer Dominique Paepe Sofie Marynissen Pascale Smets Femke Mortier Kristel Demeyere Eva Vandermeulen Emmelie Stock Eva Buresova Pieter Defauw Luc Duchateau Sylvie Daminet
author_sort	Thirawut Kongtasai
title	Liver‐type fatty acid‐binding protein and neutrophil gelatinase‐associated lipocalin in cats with chronic kidney disease and hyperthyroidism
title_short	Liver‐type fatty acid‐binding protein and neutrophil gelatinase‐associated lipocalin in cats with chronic kidney disease and hyperthyroidism
title_full	Liver‐type fatty acid‐binding protein and neutrophil gelatinase‐associated lipocalin in cats with chronic kidney disease and hyperthyroidism
title_fullStr	Liver‐type fatty acid‐binding protein and neutrophil gelatinase‐associated lipocalin in cats with chronic kidney disease and hyperthyroidism
title_full_unstemmed	Liver‐type fatty acid‐binding protein and neutrophil gelatinase‐associated lipocalin in cats with chronic kidney disease and hyperthyroidism
title_sort	liver‐type fatty acid‐binding protein and neutrophil gelatinase‐associated lipocalin in cats with chronic kidney disease and hyperthyroidism
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/cb45d94e232b4162b587c0e9dff4fcb1
work_keys_str_mv	AT thirawutkongtasai livertypefattyacidbindingproteinandneutrophilgelatinaseassociatedlipocalinincatswithchronickidneydiseaseandhyperthyroidism AT evelynemeyer livertypefattyacidbindingproteinandneutrophilgelatinaseassociatedlipocalinincatswithchronickidneydiseaseandhyperthyroidism AT dominiquepaepe livertypefattyacidbindingproteinandneutrophilgelatinaseassociatedlipocalinincatswithchronickidneydiseaseandhyperthyroidism AT sofiemarynissen livertypefattyacidbindingproteinandneutrophilgelatinaseassociatedlipocalinincatswithchronickidneydiseaseandhyperthyroidism AT pascalesmets livertypefattyacidbindingproteinandneutrophilgelatinaseassociatedlipocalinincatswithchronickidneydiseaseandhyperthyroidism AT femkemortier livertypefattyacidbindingproteinandneutrophilgelatinaseassociatedlipocalinincatswithchronickidneydiseaseandhyperthyroidism AT kristeldemeyere livertypefattyacidbindingproteinandneutrophilgelatinaseassociatedlipocalinincatswithchronickidneydiseaseandhyperthyroidism AT evavandermeulen livertypefattyacidbindingproteinandneutrophilgelatinaseassociatedlipocalinincatswithchronickidneydiseaseandhyperthyroidism AT emmeliestock livertypefattyacidbindingproteinandneutrophilgelatinaseassociatedlipocalinincatswithchronickidneydiseaseandhyperthyroidism AT evaburesova livertypefattyacidbindingproteinandneutrophilgelatinaseassociatedlipocalinincatswithchronickidneydiseaseandhyperthyroidism AT pieterdefauw livertypefattyacidbindingproteinandneutrophilgelatinaseassociatedlipocalinincatswithchronickidneydiseaseandhyperthyroidism AT lucduchateau livertypefattyacidbindingproteinandneutrophilgelatinaseassociatedlipocalinincatswithchronickidneydiseaseandhyperthyroidism AT sylviedaminet livertypefattyacidbindingproteinandneutrophilgelatinaseassociatedlipocalinincatswithchronickidneydiseaseandhyperthyroidism
_version_	1718406472494219264

Liver‐type fatty acid‐binding protein and neutrophil gelatinase‐associated lipocalin in cats with chronic kidney disease and hyperthyroidism

Ejemplares similares