Prevalence of metabolic syndrome among adults with liver function injury in rural area of Southwest China: A cross-sectional study
Abstract Abnormal liver function (ALF) plays a key role in metabolic syndrome (MetS), but only few data on the relationship between MetS and the risk factors for ALF (e.g., biotoxins) are available. We aimed to provide the prevalence of MetS and its association with the risk factors for ALF in rural...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/cb461064a908461c967b1ae2c955b949 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:cb461064a908461c967b1ae2c955b949 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:cb461064a908461c967b1ae2c955b9492021-12-02T11:52:15ZPrevalence of metabolic syndrome among adults with liver function injury in rural area of Southwest China: A cross-sectional study10.1038/s41598-017-05791-22045-2322https://doaj.org/article/cb461064a908461c967b1ae2c955b9492017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05791-2https://doaj.org/toc/2045-2322Abstract Abnormal liver function (ALF) plays a key role in metabolic syndrome (MetS), but only few data on the relationship between MetS and the risk factors for ALF (e.g., biotoxins) are available. We aimed to provide the prevalence of MetS and its association with the risk factors for ALF in rural area of Southwest China. A cross-sectional study within the hepatocellular carcinoma cohort was conducted, and included 5493 people with age from 30 to 85 years old. MetS was defined according to the Joint Scientific Statement. We observed that the prevalence of MetS was 31.8% (39.0% in women and 19.8% in men). Logistic regression analysis showed that significantly increased risk of MetS was found in those showing ALF (OR = 3.00, 95% CI: 2.43–3.71). Significantly decreased risk of MetS was found in those with higher HBV DNA titers (OR = 0.49, 95% CI: 0.33–0.74), and in those with higher aflatoxin B1 exposure (estimated daily intake, EDI) (OR = 0.60, 95% CI: 0.53–0.67). No significant change was found in those with higher microcystin-LR exposure (EDI). Therefore, the different risk factors for ALF might exert different effects on MetS. However, there should be an interaction effect existing that might decide the severity of MetS.Hui ZengHui LinWenyi LiuJia WangLingqiao WangChuanfen ZhengYao TanYujing HuangLixiong HeJiaohua LuoChaowen PuRenping ZhangXiaohong YangYingqiao TianZhiqun QiuJi-an ChenYang LuoXiaobin FengGuosheng XiaoLiping WuWeiqun ShuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Hui Zeng Hui Lin Wenyi Liu Jia Wang Lingqiao Wang Chuanfen Zheng Yao Tan Yujing Huang Lixiong He Jiaohua Luo Chaowen Pu Renping Zhang Xiaohong Yang Yingqiao Tian Zhiqun Qiu Ji-an Chen Yang Luo Xiaobin Feng Guosheng Xiao Liping Wu Weiqun Shu Prevalence of metabolic syndrome among adults with liver function injury in rural area of Southwest China: A cross-sectional study |
| description |
Abstract Abnormal liver function (ALF) plays a key role in metabolic syndrome (MetS), but only few data on the relationship between MetS and the risk factors for ALF (e.g., biotoxins) are available. We aimed to provide the prevalence of MetS and its association with the risk factors for ALF in rural area of Southwest China. A cross-sectional study within the hepatocellular carcinoma cohort was conducted, and included 5493 people with age from 30 to 85 years old. MetS was defined according to the Joint Scientific Statement. We observed that the prevalence of MetS was 31.8% (39.0% in women and 19.8% in men). Logistic regression analysis showed that significantly increased risk of MetS was found in those showing ALF (OR = 3.00, 95% CI: 2.43–3.71). Significantly decreased risk of MetS was found in those with higher HBV DNA titers (OR = 0.49, 95% CI: 0.33–0.74), and in those with higher aflatoxin B1 exposure (estimated daily intake, EDI) (OR = 0.60, 95% CI: 0.53–0.67). No significant change was found in those with higher microcystin-LR exposure (EDI). Therefore, the different risk factors for ALF might exert different effects on MetS. However, there should be an interaction effect existing that might decide the severity of MetS. |
| format |
article |
| author |
Hui Zeng Hui Lin Wenyi Liu Jia Wang Lingqiao Wang Chuanfen Zheng Yao Tan Yujing Huang Lixiong He Jiaohua Luo Chaowen Pu Renping Zhang Xiaohong Yang Yingqiao Tian Zhiqun Qiu Ji-an Chen Yang Luo Xiaobin Feng Guosheng Xiao Liping Wu Weiqun Shu |
| author_facet |
Hui Zeng Hui Lin Wenyi Liu Jia Wang Lingqiao Wang Chuanfen Zheng Yao Tan Yujing Huang Lixiong He Jiaohua Luo Chaowen Pu Renping Zhang Xiaohong Yang Yingqiao Tian Zhiqun Qiu Ji-an Chen Yang Luo Xiaobin Feng Guosheng Xiao Liping Wu Weiqun Shu |
| author_sort |
Hui Zeng |
| title |
Prevalence of metabolic syndrome among adults with liver function injury in rural area of Southwest China: A cross-sectional study |
| title_short |
Prevalence of metabolic syndrome among adults with liver function injury in rural area of Southwest China: A cross-sectional study |
| title_full |
Prevalence of metabolic syndrome among adults with liver function injury in rural area of Southwest China: A cross-sectional study |
| title_fullStr |
Prevalence of metabolic syndrome among adults with liver function injury in rural area of Southwest China: A cross-sectional study |
| title_full_unstemmed |
Prevalence of metabolic syndrome among adults with liver function injury in rural area of Southwest China: A cross-sectional study |
| title_sort |
prevalence of metabolic syndrome among adults with liver function injury in rural area of southwest china: a cross-sectional study |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/cb461064a908461c967b1ae2c955b949 |
| work_keys_str_mv |
AT huizeng prevalenceofmetabolicsyndromeamongadultswithliverfunctioninjuryinruralareaofsouthwestchinaacrosssectionalstudy AT huilin prevalenceofmetabolicsyndromeamongadultswithliverfunctioninjuryinruralareaofsouthwestchinaacrosssectionalstudy AT wenyiliu prevalenceofmetabolicsyndromeamongadultswithliverfunctioninjuryinruralareaofsouthwestchinaacrosssectionalstudy AT jiawang prevalenceofmetabolicsyndromeamongadultswithliverfunctioninjuryinruralareaofsouthwestchinaacrosssectionalstudy AT lingqiaowang prevalenceofmetabolicsyndromeamongadultswithliverfunctioninjuryinruralareaofsouthwestchinaacrosssectionalstudy AT chuanfenzheng prevalenceofmetabolicsyndromeamongadultswithliverfunctioninjuryinruralareaofsouthwestchinaacrosssectionalstudy AT yaotan prevalenceofmetabolicsyndromeamongadultswithliverfunctioninjuryinruralareaofsouthwestchinaacrosssectionalstudy AT yujinghuang prevalenceofmetabolicsyndromeamongadultswithliverfunctioninjuryinruralareaofsouthwestchinaacrosssectionalstudy AT lixionghe prevalenceofmetabolicsyndromeamongadultswithliverfunctioninjuryinruralareaofsouthwestchinaacrosssectionalstudy AT jiaohualuo prevalenceofmetabolicsyndromeamongadultswithliverfunctioninjuryinruralareaofsouthwestchinaacrosssectionalstudy AT chaowenpu prevalenceofmetabolicsyndromeamongadultswithliverfunctioninjuryinruralareaofsouthwestchinaacrosssectionalstudy AT renpingzhang prevalenceofmetabolicsyndromeamongadultswithliverfunctioninjuryinruralareaofsouthwestchinaacrosssectionalstudy AT xiaohongyang prevalenceofmetabolicsyndromeamongadultswithliverfunctioninjuryinruralareaofsouthwestchinaacrosssectionalstudy AT yingqiaotian prevalenceofmetabolicsyndromeamongadultswithliverfunctioninjuryinruralareaofsouthwestchinaacrosssectionalstudy AT zhiqunqiu prevalenceofmetabolicsyndromeamongadultswithliverfunctioninjuryinruralareaofsouthwestchinaacrosssectionalstudy AT jianchen prevalenceofmetabolicsyndromeamongadultswithliverfunctioninjuryinruralareaofsouthwestchinaacrosssectionalstudy AT yangluo prevalenceofmetabolicsyndromeamongadultswithliverfunctioninjuryinruralareaofsouthwestchinaacrosssectionalstudy AT xiaobinfeng prevalenceofmetabolicsyndromeamongadultswithliverfunctioninjuryinruralareaofsouthwestchinaacrosssectionalstudy AT guoshengxiao prevalenceofmetabolicsyndromeamongadultswithliverfunctioninjuryinruralareaofsouthwestchinaacrosssectionalstudy AT lipingwu prevalenceofmetabolicsyndromeamongadultswithliverfunctioninjuryinruralareaofsouthwestchinaacrosssectionalstudy AT weiqunshu prevalenceofmetabolicsyndromeamongadultswithliverfunctioninjuryinruralareaofsouthwestchinaacrosssectionalstudy |
| _version_ |
1718395131600568320 |