Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a

Metabolic diseases have been associated with cognitive impairment. Here, the authors show that brain insulin resistance induced by high-fat diet leads to increased palmitoylation of AMPA receptors and thus changes in hippocampal plasticity, learning and memory.

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Autores principales:	Matteo Spinelli, Salvatore Fusco, Marco Mainardi, Federico Scala, Francesca Natale, Rosita Lapenta, Andrea Mattera, Marco Rinaudo, Domenica Donatella Li Puma, Cristian Ripoli, Alfonso Grassi, Marcello D’Ascenzo, Claudio Grassi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cb4640a300fa422e8b1d52b272e63d1d
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spelling	oai:doaj.org-article:cb4640a300fa422e8b1d52b272e63d1d2021-12-02T14:40:57ZBrain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a10.1038/s41467-017-02221-92041-1723https://doaj.org/article/cb4640a300fa422e8b1d52b272e63d1d2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02221-9https://doaj.org/toc/2041-1723Metabolic diseases have been associated with cognitive impairment. Here, the authors show that brain insulin resistance induced by high-fat diet leads to increased palmitoylation of AMPA receptors and thus changes in hippocampal plasticity, learning and memory.Matteo SpinelliSalvatore FuscoMarco MainardiFederico ScalaFrancesca NataleRosita LapentaAndrea MatteraMarco RinaudoDomenica Donatella Li PumaCristian RipoliAlfonso GrassiMarcello D’AscenzoClaudio GrassiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matteo Spinelli Salvatore Fusco Marco Mainardi Federico Scala Francesca Natale Rosita Lapenta Andrea Mattera Marco Rinaudo Domenica Donatella Li Puma Cristian Ripoli Alfonso Grassi Marcello D’Ascenzo Claudio Grassi Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a
description	Metabolic diseases have been associated with cognitive impairment. Here, the authors show that brain insulin resistance induced by high-fat diet leads to increased palmitoylation of AMPA receptors and thus changes in hippocampal plasticity, learning and memory.
format	article
author	Matteo Spinelli Salvatore Fusco Marco Mainardi Federico Scala Francesca Natale Rosita Lapenta Andrea Mattera Marco Rinaudo Domenica Donatella Li Puma Cristian Ripoli Alfonso Grassi Marcello D’Ascenzo Claudio Grassi
author_facet	Matteo Spinelli Salvatore Fusco Marco Mainardi Federico Scala Francesca Natale Rosita Lapenta Andrea Mattera Marco Rinaudo Domenica Donatella Li Puma Cristian Ripoli Alfonso Grassi Marcello D’Ascenzo Claudio Grassi
author_sort	Matteo Spinelli
title	Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a
title_short	Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a
title_full	Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a
title_fullStr	Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a
title_full_unstemmed	Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a
title_sort	brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing glua1 palmitoylation through foxo3a
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cb4640a300fa422e8b1d52b272e63d1d
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Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a

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