Risk Groups of Developing Active Tuberculosis in Liver Transplant Recipients in a Tuberculosis Endemic Area: Risk Stratification by Chest Image and Interferon Gamma Release Assay

Objectives: We implemented a stratified risk analysis to predict the development of active tuberculosis (TB) in liver transplantation (LT) recipients based on IGRA and chest images in a TB-endemic area. Methods: In this retrospective cohort study, LT recipients who tested for IGRA between May 2008 a...

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Autores principales:	Si-Ho Kim, Suhyun Oh, Eliel Nham, Jae-Hoon Ko, Kyungmin Huh, Sun Young Cho, Cheol-In Kang, Doo Ryeon Chung, Gyu-Seong Choi, Jong Man Kim, Jae-Won Joh, Kyong Ran Peck
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Tuberculosis Latent tuberculosis infection Liver transplantation Interferon-gamma release assay Chest image Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/cb479d3c23454c29b0914f9b07c397f0
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spelling	oai:doaj.org-article:cb479d3c23454c29b0914f9b07c397f02021-11-20T04:56:17ZRisk Groups of Developing Active Tuberculosis in Liver Transplant Recipients in a Tuberculosis Endemic Area: Risk Stratification by Chest Image and Interferon Gamma Release Assay1201-971210.1016/j.ijid.2021.10.043https://doaj.org/article/cb479d3c23454c29b0914f9b07c397f02021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221008286https://doaj.org/toc/1201-9712Objectives: We implemented a stratified risk analysis to predict the development of active tuberculosis (TB) in liver transplantation (LT) recipients based on IGRA and chest images in a TB-endemic area. Methods: In this retrospective cohort study, LT recipients who tested for IGRA between May 2008 and December 2017 were included. Chest images compatible with old TB lesions were considered as positive images. LT recipients were divided into six groups: LT recipients with history of treated TB, image (+)/IGRA (+), image (+)/IGRA (-), image (-)/IGRA (+), image (-)/IGRA (-) and LTBI treated. The Cox regression model was used to analyze risk groups. Results: Among the 717 eligible LT recipients included in this study, 21 patients developed active TB. Incidence rates of TB were 2,261, 724, and 119 cases/100,000 person-years in the 1st, 2nd, and ≥ 3rd year after transplantation, respectively. History of treated TB (HR 18.92; 95% CI 4.10–87.25) and image (+)/IGRA (+) (HR 10.86; 95% CI 2.75–42.89) were independent risk factors for developing active TB. IGRA (+) with a negative image was not a risk factor. Conclusions: Our findings suggested that both IGRA and chest images should be considered to identify risk groups for LTBI treatment.Si-Ho KimSuhyun OhEliel NhamJae-Hoon KoKyungmin HuhSun Young ChoCheol-In KangDoo Ryeon ChungGyu-Seong ChoiJong Man KimJae-Won JohKyong Ran PeckElsevierarticleTuberculosisLatent tuberculosis infectionLiver transplantationInterferon-gamma release assayChest imageInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 113, Iss , Pp 359-366 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Tuberculosis Latent tuberculosis infection Liver transplantation Interferon-gamma release assay Chest image Infectious and parasitic diseases RC109-216
spellingShingle	Tuberculosis Latent tuberculosis infection Liver transplantation Interferon-gamma release assay Chest image Infectious and parasitic diseases RC109-216 Si-Ho Kim Suhyun Oh Eliel Nham Jae-Hoon Ko Kyungmin Huh Sun Young Cho Cheol-In Kang Doo Ryeon Chung Gyu-Seong Choi Jong Man Kim Jae-Won Joh Kyong Ran Peck Risk Groups of Developing Active Tuberculosis in Liver Transplant Recipients in a Tuberculosis Endemic Area: Risk Stratification by Chest Image and Interferon Gamma Release Assay
description	Objectives: We implemented a stratified risk analysis to predict the development of active tuberculosis (TB) in liver transplantation (LT) recipients based on IGRA and chest images in a TB-endemic area. Methods: In this retrospective cohort study, LT recipients who tested for IGRA between May 2008 and December 2017 were included. Chest images compatible with old TB lesions were considered as positive images. LT recipients were divided into six groups: LT recipients with history of treated TB, image (+)/IGRA (+), image (+)/IGRA (-), image (-)/IGRA (+), image (-)/IGRA (-) and LTBI treated. The Cox regression model was used to analyze risk groups. Results: Among the 717 eligible LT recipients included in this study, 21 patients developed active TB. Incidence rates of TB were 2,261, 724, and 119 cases/100,000 person-years in the 1st, 2nd, and ≥ 3rd year after transplantation, respectively. History of treated TB (HR 18.92; 95% CI 4.10–87.25) and image (+)/IGRA (+) (HR 10.86; 95% CI 2.75–42.89) were independent risk factors for developing active TB. IGRA (+) with a negative image was not a risk factor. Conclusions: Our findings suggested that both IGRA and chest images should be considered to identify risk groups for LTBI treatment.
format	article
author	Si-Ho Kim Suhyun Oh Eliel Nham Jae-Hoon Ko Kyungmin Huh Sun Young Cho Cheol-In Kang Doo Ryeon Chung Gyu-Seong Choi Jong Man Kim Jae-Won Joh Kyong Ran Peck
author_facet	Si-Ho Kim Suhyun Oh Eliel Nham Jae-Hoon Ko Kyungmin Huh Sun Young Cho Cheol-In Kang Doo Ryeon Chung Gyu-Seong Choi Jong Man Kim Jae-Won Joh Kyong Ran Peck
author_sort	Si-Ho Kim
title	Risk Groups of Developing Active Tuberculosis in Liver Transplant Recipients in a Tuberculosis Endemic Area: Risk Stratification by Chest Image and Interferon Gamma Release Assay
title_short	Risk Groups of Developing Active Tuberculosis in Liver Transplant Recipients in a Tuberculosis Endemic Area: Risk Stratification by Chest Image and Interferon Gamma Release Assay
title_full	Risk Groups of Developing Active Tuberculosis in Liver Transplant Recipients in a Tuberculosis Endemic Area: Risk Stratification by Chest Image and Interferon Gamma Release Assay
title_fullStr	Risk Groups of Developing Active Tuberculosis in Liver Transplant Recipients in a Tuberculosis Endemic Area: Risk Stratification by Chest Image and Interferon Gamma Release Assay
title_full_unstemmed	Risk Groups of Developing Active Tuberculosis in Liver Transplant Recipients in a Tuberculosis Endemic Area: Risk Stratification by Chest Image and Interferon Gamma Release Assay
title_sort	risk groups of developing active tuberculosis in liver transplant recipients in a tuberculosis endemic area: risk stratification by chest image and interferon gamma release assay
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/cb479d3c23454c29b0914f9b07c397f0
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Risk Groups of Developing Active Tuberculosis in Liver Transplant Recipients in a Tuberculosis Endemic Area: Risk Stratification by Chest Image and Interferon Gamma Release Assay

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