Current Omics Trends in Personalised Head and Neck Cancer Chemoradiotherapy

Chemoradiotherapy remains the most common management of locally advanced head and neck cancer. While both treatment components have greatly developed over the years, the quality of life and long-term survival of patients undergoing treatment for head and neck malignancies are still poor. Research in...

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Autores principales:	Loredana G. Marcu, David C. Marcu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	squamous cell carcinoma toxicity drug resistance radiomics dosiomics pharmacomics Medicine R
Acceso en línea:	https://doaj.org/article/cb493dc051b449a68786a8625766915e
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spelling	oai:doaj.org-article:cb493dc051b449a68786a8625766915e2021-11-25T18:07:05ZCurrent Omics Trends in Personalised Head and Neck Cancer Chemoradiotherapy10.3390/jpm111110942075-4426https://doaj.org/article/cb493dc051b449a68786a8625766915e2021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1094https://doaj.org/toc/2075-4426Chemoradiotherapy remains the most common management of locally advanced head and neck cancer. While both treatment components have greatly developed over the years, the quality of life and long-term survival of patients undergoing treatment for head and neck malignancies are still poor. Research in head and neck oncology is equally focused on the improvement of tumour response to treatment and on the limitation of normal tissue toxicity. In this regard, personalised therapy through a multi-omics approach targeting patient management from diagnosis to treatment shows promising results. The aim of this paper is to discuss the latest results regarding the personalised approach to chemoradiotherapy of head and neck cancer by gathering the findings of the newest omics, involving radiotherapy (dosiomics), chemotherapy (pharmacomics), and medical imaging for treatment monitoring (radiomics). The incorporation of these omics into head and neck cancer management offers multiple viewpoints to treatment that represent the foundation of personalised therapy.Loredana G. MarcuDavid C. MarcuMDPI AGarticlesquamous cell carcinomatoxicitydrug resistanceradiomicsdosiomicspharmacomicsMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1094, p 1094 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	squamous cell carcinoma toxicity drug resistance radiomics dosiomics pharmacomics Medicine R
spellingShingle	squamous cell carcinoma toxicity drug resistance radiomics dosiomics pharmacomics Medicine R Loredana G. Marcu David C. Marcu Current Omics Trends in Personalised Head and Neck Cancer Chemoradiotherapy
description	Chemoradiotherapy remains the most common management of locally advanced head and neck cancer. While both treatment components have greatly developed over the years, the quality of life and long-term survival of patients undergoing treatment for head and neck malignancies are still poor. Research in head and neck oncology is equally focused on the improvement of tumour response to treatment and on the limitation of normal tissue toxicity. In this regard, personalised therapy through a multi-omics approach targeting patient management from diagnosis to treatment shows promising results. The aim of this paper is to discuss the latest results regarding the personalised approach to chemoradiotherapy of head and neck cancer by gathering the findings of the newest omics, involving radiotherapy (dosiomics), chemotherapy (pharmacomics), and medical imaging for treatment monitoring (radiomics). The incorporation of these omics into head and neck cancer management offers multiple viewpoints to treatment that represent the foundation of personalised therapy.
format	article
author	Loredana G. Marcu David C. Marcu
author_facet	Loredana G. Marcu David C. Marcu
author_sort	Loredana G. Marcu
title	Current Omics Trends in Personalised Head and Neck Cancer Chemoradiotherapy
title_short	Current Omics Trends in Personalised Head and Neck Cancer Chemoradiotherapy
title_full	Current Omics Trends in Personalised Head and Neck Cancer Chemoradiotherapy
title_fullStr	Current Omics Trends in Personalised Head and Neck Cancer Chemoradiotherapy
title_full_unstemmed	Current Omics Trends in Personalised Head and Neck Cancer Chemoradiotherapy
title_sort	current omics trends in personalised head and neck cancer chemoradiotherapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cb493dc051b449a68786a8625766915e
work_keys_str_mv	AT loredanagmarcu currentomicstrendsinpersonalisedheadandneckcancerchemoradiotherapy AT davidcmarcu currentomicstrendsinpersonalisedheadandneckcancerchemoradiotherapy
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Current Omics Trends in Personalised Head and Neck Cancer Chemoradiotherapy

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