Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides

A major challenge for the application of peptide therapeutics is their short half-lifein vivo. Here, the authors design peptide-fatty acid chimeras bearing an engineered linker that promotes albumin binding and allows longer circulation times of therapeutic peptides in animal models.

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Autores principales:	Alessandro Zorzi, Simon J. Middendorp, Jonas Wilbs, Kaycie Deyle, Christian Heinis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cb4c3effd8b24083a11b07d420333e2b
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spelling	oai:doaj.org-article:cb4c3effd8b24083a11b07d420333e2b2021-12-02T14:42:08ZAcylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides10.1038/ncomms160922041-1723https://doaj.org/article/cb4c3effd8b24083a11b07d420333e2b2017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16092https://doaj.org/toc/2041-1723A major challenge for the application of peptide therapeutics is their short half-lifein vivo. Here, the authors design peptide-fatty acid chimeras bearing an engineered linker that promotes albumin binding and allows longer circulation times of therapeutic peptides in animal models.Alessandro ZorziSimon J. MiddendorpJonas WilbsKaycie DeyleChristian HeinisNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alessandro Zorzi Simon J. Middendorp Jonas Wilbs Kaycie Deyle Christian Heinis Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides
description	A major challenge for the application of peptide therapeutics is their short half-lifein vivo. Here, the authors design peptide-fatty acid chimeras bearing an engineered linker that promotes albumin binding and allows longer circulation times of therapeutic peptides in animal models.
format	article
author	Alessandro Zorzi Simon J. Middendorp Jonas Wilbs Kaycie Deyle Christian Heinis
author_facet	Alessandro Zorzi Simon J. Middendorp Jonas Wilbs Kaycie Deyle Christian Heinis
author_sort	Alessandro Zorzi
title	Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides
title_short	Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides
title_full	Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides
title_fullStr	Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides
title_full_unstemmed	Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides
title_sort	acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cb4c3effd8b24083a11b07d420333e2b
work_keys_str_mv	AT alessandrozorzi acylatedheptapeptidebindsalbuminwithhighaffinityandapplicationastagfurnisheslongactingpeptides AT simonjmiddendorp acylatedheptapeptidebindsalbuminwithhighaffinityandapplicationastagfurnisheslongactingpeptides AT jonaswilbs acylatedheptapeptidebindsalbuminwithhighaffinityandapplicationastagfurnisheslongactingpeptides AT kayciedeyle acylatedheptapeptidebindsalbuminwithhighaffinityandapplicationastagfurnisheslongactingpeptides AT christianheinis acylatedheptapeptidebindsalbuminwithhighaffinityandapplicationastagfurnisheslongactingpeptides
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Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides

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