Involvement of Intestinal Goblet Cells and Changes in Sodium Glucose Transporters Expression: Possible Therapeutic Targets in Autistic BTBR T<sup>+</sup>Itpr3<sup>tf</sup>/J Mice

Autism spectrum disorder is a neurodevelopmental syndrome with a complicated etiology and could be responsible for disrupted gastrointestinal tract microbiota. The aim of this work was to study intestinal samples from an autistic animal model (BTBR mouse strain) to better describe gastrointestinal a...

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Autores principales:	Caterina Franco, Francesca Bonomini, Elisa Borsani, Stefania Castrezzati, Lorenzo Franceschetti, Rita Rezzani
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	autism spectrum disorder BTBR mice goblet cells Sglt-1 and Sglt-3 proteins light ultrastructural and biochemical analyses Medicine R
Acceso en línea:	https://doaj.org/article/cb4e177b05b24ccb8b1e92aee1ce4411
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spelling	oai:doaj.org-article:cb4e177b05b24ccb8b1e92aee1ce44112021-11-11T16:28:35ZInvolvement of Intestinal Goblet Cells and Changes in Sodium Glucose Transporters Expression: Possible Therapeutic Targets in Autistic BTBR T<sup>+</sup>Itpr3<sup>tf</sup>/J Mice10.3390/ijerph1821113281660-46011661-7827https://doaj.org/article/cb4e177b05b24ccb8b1e92aee1ce44112021-10-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11328https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Autism spectrum disorder is a neurodevelopmental syndrome with a complicated etiology and could be responsible for disrupted gastrointestinal tract microbiota. The aim of this work was to study intestinal samples from an autistic animal model (BTBR mouse strain) to better describe gastrointestinal alterations. We performed a morphological and biological evaluation of small intestine samples. In terms of morphology, we studied the goblet cells, cells of intestinal mucosal responsible for the production and maintenance of the protective mucous blanket. Alterations in their secretion may indicate an altered rate of mucus synthesis and this is one of the possible causes of gastrointestinal problems. In terms of biological evaluation, impaired regulation of glucose homeostasis regulated by sodium-glucose transporters has been suggested as an important component of obesity and associated comorbidities; therefore, this study analyzed the expression of sodium/glucose transporter-1 and -3 in BTBR mice to better define their role. We demonstrated that, in BTBR mice as compared to C57BL/6J (B6) strain animals: (1) The goblet cells had different protein content in their vesicles and apparently a larger number of Golgi cisternae; (2) the expression and level of sodium/glucose transporters were higher. These findings could suggest new possible targets in autism spectrum disorder to maintain mucus barrier function.Caterina FrancoFrancesca BonominiElisa BorsaniStefania CastrezzatiLorenzo FranceschettiRita RezzaniMDPI AGarticleautism spectrum disorderBTBR micegoblet cellsSglt-1 and Sglt-3 proteinslightultrastructural and biochemical analysesMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11328, p 11328 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autism spectrum disorder BTBR mice goblet cells Sglt-1 and Sglt-3 proteins light ultrastructural and biochemical analyses Medicine R
spellingShingle	autism spectrum disorder BTBR mice goblet cells Sglt-1 and Sglt-3 proteins light ultrastructural and biochemical analyses Medicine R Caterina Franco Francesca Bonomini Elisa Borsani Stefania Castrezzati Lorenzo Franceschetti Rita Rezzani Involvement of Intestinal Goblet Cells and Changes in Sodium Glucose Transporters Expression: Possible Therapeutic Targets in Autistic BTBR T<sup>+</sup>Itpr3<sup>tf</sup>/J Mice
description	Autism spectrum disorder is a neurodevelopmental syndrome with a complicated etiology and could be responsible for disrupted gastrointestinal tract microbiota. The aim of this work was to study intestinal samples from an autistic animal model (BTBR mouse strain) to better describe gastrointestinal alterations. We performed a morphological and biological evaluation of small intestine samples. In terms of morphology, we studied the goblet cells, cells of intestinal mucosal responsible for the production and maintenance of the protective mucous blanket. Alterations in their secretion may indicate an altered rate of mucus synthesis and this is one of the possible causes of gastrointestinal problems. In terms of biological evaluation, impaired regulation of glucose homeostasis regulated by sodium-glucose transporters has been suggested as an important component of obesity and associated comorbidities; therefore, this study analyzed the expression of sodium/glucose transporter-1 and -3 in BTBR mice to better define their role. We demonstrated that, in BTBR mice as compared to C57BL/6J (B6) strain animals: (1) The goblet cells had different protein content in their vesicles and apparently a larger number of Golgi cisternae; (2) the expression and level of sodium/glucose transporters were higher. These findings could suggest new possible targets in autism spectrum disorder to maintain mucus barrier function.
format	article
author	Caterina Franco Francesca Bonomini Elisa Borsani Stefania Castrezzati Lorenzo Franceschetti Rita Rezzani
author_facet	Caterina Franco Francesca Bonomini Elisa Borsani Stefania Castrezzati Lorenzo Franceschetti Rita Rezzani
author_sort	Caterina Franco
title	Involvement of Intestinal Goblet Cells and Changes in Sodium Glucose Transporters Expression: Possible Therapeutic Targets in Autistic BTBR T<sup>+</sup>Itpr3<sup>tf</sup>/J Mice
title_short	Involvement of Intestinal Goblet Cells and Changes in Sodium Glucose Transporters Expression: Possible Therapeutic Targets in Autistic BTBR T<sup>+</sup>Itpr3<sup>tf</sup>/J Mice
title_full	Involvement of Intestinal Goblet Cells and Changes in Sodium Glucose Transporters Expression: Possible Therapeutic Targets in Autistic BTBR T<sup>+</sup>Itpr3<sup>tf</sup>/J Mice
title_fullStr	Involvement of Intestinal Goblet Cells and Changes in Sodium Glucose Transporters Expression: Possible Therapeutic Targets in Autistic BTBR T<sup>+</sup>Itpr3<sup>tf</sup>/J Mice
title_full_unstemmed	Involvement of Intestinal Goblet Cells and Changes in Sodium Glucose Transporters Expression: Possible Therapeutic Targets in Autistic BTBR T<sup>+</sup>Itpr3<sup>tf</sup>/J Mice
title_sort	involvement of intestinal goblet cells and changes in sodium glucose transporters expression: possible therapeutic targets in autistic btbr t<sup>+</sup>itpr3<sup>tf</sup>/j mice
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cb4e177b05b24ccb8b1e92aee1ce4411
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Involvement of Intestinal Goblet Cells and Changes in Sodium Glucose Transporters Expression: Possible Therapeutic Targets in Autistic BTBR T<sup>+</sup>Itpr3<sup>tf</sup>/J Mice

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