Alterations of lymphocyte subpopulations and TGF-β in children with transient or persistent cow’s milk allergy

The aim of the study was to evaluate changes in surface receptor expression of B and T lymphocytes and concentration of TGF-β in children who either developed tolerance to cow’s milk protein (CMP) or manifested persistent cow’s milk allergy (CMA). The study involved 30 patients with CMA who underwen...

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Autores principales:	Anna Bobrus-Chociej, Urszula Daniluk, Marek Alifier, Anna Stasiak-Barmuta, Maciej Gustaw Kaczmarski
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	cow’s milk allergy food tolerance lymphocyte subpopulations tgf-β Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/cb4e35b3eebc4764bb1c12c50842fdd6
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spelling	oai:doaj.org-article:cb4e35b3eebc4764bb1c12c50842fdd62021-11-26T11:19:46ZAlterations of lymphocyte subpopulations and TGF-β in children with transient or persistent cow’s milk allergy0954-01051465-344310.1080/09540105.2017.1387234https://doaj.org/article/cb4e35b3eebc4764bb1c12c50842fdd62018-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09540105.2017.1387234https://doaj.org/toc/0954-0105https://doaj.org/toc/1465-3443The aim of the study was to evaluate changes in surface receptor expression of B and T lymphocytes and concentration of TGF-β in children who either developed tolerance to cow’s milk protein (CMP) or manifested persistent cow’s milk allergy (CMA). The study involved 30 patients with CMA who underwent an open food challenge after 12 months of milk-free diet. After the milk challenge, decreased concentration of CD19+CD23+ was observed in children who acquired tolerance to CMP, in comparison with the test before cow’s milk (CM) challenge (42.2% vs. 29.1%, p = .006). The same group demonstrated lower concentration of TGF-β than patients with persistent allergy (median 37.9 pg/ml vs. 52.8 pg/ml, p = .003, respectively). Moreover, before CM challenge, higher percentage of CD3+CD8+CD28+CD152+ cells (median 2.88% vs. 1.2%, p = .03) and CD3+CD4+CD25+CD62L+ (median 42.3% vs. 13.4%, p = .032) was noted in children who acquired tolerance to CMP, in comparison with subjects who remained allergic to CMP.Anna Bobrus-ChociejUrszula DanilukMarek AlifierAnna Stasiak-BarmutaMaciej Gustaw KaczmarskiTaylor & Francis Grouparticlecow’s milk allergyfood tolerancelymphocyte subpopulationstgf-βAgriculture (General)S1-972Immunologic diseases. AllergyRC581-607ENFood and Agricultural Immunology, Vol 29, Iss 1, Pp 400-411 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	cow’s milk allergy food tolerance lymphocyte subpopulations tgf-β Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
spellingShingle	cow’s milk allergy food tolerance lymphocyte subpopulations tgf-β Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 Anna Bobrus-Chociej Urszula Daniluk Marek Alifier Anna Stasiak-Barmuta Maciej Gustaw Kaczmarski Alterations of lymphocyte subpopulations and TGF-β in children with transient or persistent cow’s milk allergy
description	The aim of the study was to evaluate changes in surface receptor expression of B and T lymphocytes and concentration of TGF-β in children who either developed tolerance to cow’s milk protein (CMP) or manifested persistent cow’s milk allergy (CMA). The study involved 30 patients with CMA who underwent an open food challenge after 12 months of milk-free diet. After the milk challenge, decreased concentration of CD19+CD23+ was observed in children who acquired tolerance to CMP, in comparison with the test before cow’s milk (CM) challenge (42.2% vs. 29.1%, p = .006). The same group demonstrated lower concentration of TGF-β than patients with persistent allergy (median 37.9 pg/ml vs. 52.8 pg/ml, p = .003, respectively). Moreover, before CM challenge, higher percentage of CD3+CD8+CD28+CD152+ cells (median 2.88% vs. 1.2%, p = .03) and CD3+CD4+CD25+CD62L+ (median 42.3% vs. 13.4%, p = .032) was noted in children who acquired tolerance to CMP, in comparison with subjects who remained allergic to CMP.
format	article
author	Anna Bobrus-Chociej Urszula Daniluk Marek Alifier Anna Stasiak-Barmuta Maciej Gustaw Kaczmarski
author_facet	Anna Bobrus-Chociej Urszula Daniluk Marek Alifier Anna Stasiak-Barmuta Maciej Gustaw Kaczmarski
author_sort	Anna Bobrus-Chociej
title	Alterations of lymphocyte subpopulations and TGF-β in children with transient or persistent cow’s milk allergy
title_short	Alterations of lymphocyte subpopulations and TGF-β in children with transient or persistent cow’s milk allergy
title_full	Alterations of lymphocyte subpopulations and TGF-β in children with transient or persistent cow’s milk allergy
title_fullStr	Alterations of lymphocyte subpopulations and TGF-β in children with transient or persistent cow’s milk allergy
title_full_unstemmed	Alterations of lymphocyte subpopulations and TGF-β in children with transient or persistent cow’s milk allergy
title_sort	alterations of lymphocyte subpopulations and tgf-β in children with transient or persistent cow’s milk allergy
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/cb4e35b3eebc4764bb1c12c50842fdd6
work_keys_str_mv	AT annabobruschociej alterationsoflymphocytesubpopulationsandtgfbinchildrenwithtransientorpersistentcowsmilkallergy AT urszuladaniluk alterationsoflymphocytesubpopulationsandtgfbinchildrenwithtransientorpersistentcowsmilkallergy AT marekalifier alterationsoflymphocytesubpopulationsandtgfbinchildrenwithtransientorpersistentcowsmilkallergy AT annastasiakbarmuta alterationsoflymphocytesubpopulationsandtgfbinchildrenwithtransientorpersistentcowsmilkallergy AT maciejgustawkaczmarski alterationsoflymphocytesubpopulationsandtgfbinchildrenwithtransientorpersistentcowsmilkallergy
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Alterations of lymphocyte subpopulations and TGF-β in children with transient or persistent cow’s milk allergy

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