A mixed-methods pilot study of handheld fan for breathlessness in interstitial lung disease

Abstract Dyspnoea is a cardinal symptom of fibrotic interstitial lung disease (ILD), with a lack of proven effective therapies. With emerging evidence of the role of facial and nasal airflow for relieving breathlessness, this pilot study was conducted to examine the feasibility of conducting a clini...

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Autores principales:	Yet H. Khor, Kirushallini Saravanan, Anne E. Holland, Joanna Y. T. Lee, Christopher J. Ryerson, Christine F. McDonald, Nicole S. L. Goh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cb52a0d140ab45edb402fb7a2ff021ce
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spelling	oai:doaj.org-article:cb52a0d140ab45edb402fb7a2ff021ce2021-12-02T16:36:12ZA mixed-methods pilot study of handheld fan for breathlessness in interstitial lung disease10.1038/s41598-021-86326-82045-2322https://doaj.org/article/cb52a0d140ab45edb402fb7a2ff021ce2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86326-8https://doaj.org/toc/2045-2322Abstract Dyspnoea is a cardinal symptom of fibrotic interstitial lung disease (ILD), with a lack of proven effective therapies. With emerging evidence of the role of facial and nasal airflow for relieving breathlessness, this pilot study was conducted to examine the feasibility of conducting a clinical trial of a handheld fan (HHF) for dyspnoea management in patients with fibrotic ILD. In this mixed-methods, randomised, assessor-blinded, controlled trial, 30 participants with fibrotic ILD who were dyspnoeic with a modified Medical Research Council Dyspnoea grade ≥ 2 were randomised to a HHF for symptom control or no intervention for 2 weeks. Primary outcomes were trial feasibility, change in Dyspnoea-12 scores at Week 2, and participants’ perspectives on using a HHF for dyspnoea management. Study recruitment was completed within nine months at a single site. Successful assessor blinding was achieved in the fan group [Bang’s Blinding Index − 0.08 (95% CI − 0.45, 0.30)] but not the control group [0.47 (0.12, 0.81)]. There were no significant between-group differences for the change in Dyspnoea-12 or secondary efficacy outcomes. During qualitative interviews, participants reported that using the HHF relieved breathlessness and provided relaxation, despite initial scepticism about its therapeutic benefit. Oxygen-experienced participants described the HHF being easier to use, but not as effective for symptomatic relief, compared to oxygen therapy. Our results confirmed the feasibility of a clinical trial of a HHF in fibrotic ILD. There was a high level of patient acceptance of a HHF for managing dyspnoea, with patients reporting both symptomatic benefits and ease of use.Yet H. KhorKirushallini SaravananAnne E. HollandJoanna Y. T. LeeChristopher J. RyersonChristine F. McDonaldNicole S. L. GohNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yet H. Khor Kirushallini Saravanan Anne E. Holland Joanna Y. T. Lee Christopher J. Ryerson Christine F. McDonald Nicole S. L. Goh A mixed-methods pilot study of handheld fan for breathlessness in interstitial lung disease
description	Abstract Dyspnoea is a cardinal symptom of fibrotic interstitial lung disease (ILD), with a lack of proven effective therapies. With emerging evidence of the role of facial and nasal airflow for relieving breathlessness, this pilot study was conducted to examine the feasibility of conducting a clinical trial of a handheld fan (HHF) for dyspnoea management in patients with fibrotic ILD. In this mixed-methods, randomised, assessor-blinded, controlled trial, 30 participants with fibrotic ILD who were dyspnoeic with a modified Medical Research Council Dyspnoea grade ≥ 2 were randomised to a HHF for symptom control or no intervention for 2 weeks. Primary outcomes were trial feasibility, change in Dyspnoea-12 scores at Week 2, and participants’ perspectives on using a HHF for dyspnoea management. Study recruitment was completed within nine months at a single site. Successful assessor blinding was achieved in the fan group [Bang’s Blinding Index − 0.08 (95% CI − 0.45, 0.30)] but not the control group [0.47 (0.12, 0.81)]. There were no significant between-group differences for the change in Dyspnoea-12 or secondary efficacy outcomes. During qualitative interviews, participants reported that using the HHF relieved breathlessness and provided relaxation, despite initial scepticism about its therapeutic benefit. Oxygen-experienced participants described the HHF being easier to use, but not as effective for symptomatic relief, compared to oxygen therapy. Our results confirmed the feasibility of a clinical trial of a HHF in fibrotic ILD. There was a high level of patient acceptance of a HHF for managing dyspnoea, with patients reporting both symptomatic benefits and ease of use.
format	article
author	Yet H. Khor Kirushallini Saravanan Anne E. Holland Joanna Y. T. Lee Christopher J. Ryerson Christine F. McDonald Nicole S. L. Goh
author_facet	Yet H. Khor Kirushallini Saravanan Anne E. Holland Joanna Y. T. Lee Christopher J. Ryerson Christine F. McDonald Nicole S. L. Goh
author_sort	Yet H. Khor
title	A mixed-methods pilot study of handheld fan for breathlessness in interstitial lung disease
title_short	A mixed-methods pilot study of handheld fan for breathlessness in interstitial lung disease
title_full	A mixed-methods pilot study of handheld fan for breathlessness in interstitial lung disease
title_fullStr	A mixed-methods pilot study of handheld fan for breathlessness in interstitial lung disease
title_full_unstemmed	A mixed-methods pilot study of handheld fan for breathlessness in interstitial lung disease
title_sort	mixed-methods pilot study of handheld fan for breathlessness in interstitial lung disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cb52a0d140ab45edb402fb7a2ff021ce
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A mixed-methods pilot study of handheld fan for breathlessness in interstitial lung disease

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